| Individual/Entity | Most Recent Trans. | Shares Owned as of Trans. Date | BURBANK JEFFREY H
Officer | Option Exercise
16-Dec-08 | 451,701
16-Dec-08 | CHAMBON PHILIPPE
Director | Acquisition (Non Open Market)
31-Dec-09 | 31,595
31-Dec-09 | CREDIT SUISSE AG/
Beneficial Owner (10% or more) | Purchase
1-Aug-08 | 7,208,096
1-Aug-08 | FLYNN JAMES E
Beneficial Owner (10% or more) | Sale
15-Dec-09 | 733,647
15-Dec-09 | GIANNINI DANIEL A
Director | Acquisition (Non Open Market)
31-Dec-09 | 24,625
31-Dec-09 | LEWIS EARL R
Director | Ownership Statement
27-Oct-08 | 0
27-Oct-08 | MOORE CRAIG W
Director | Acquisition (Non Open Market)
31-Dec-09 | 41,999
31-Dec-09 | ORBIMED ADVISORS LLC
Director | Purchase
26-Aug-08 | 5,718,256
26-Aug-08 | PHILDIUS PETER P
Director | Sale
21-Aug-08 | 3,642
21-Aug-08 | REID PERPER
Director | Acquisition (Non Open Market)
31-Dec-09 | 189,393
31-Dec-09 | SHEA THOMAS
Officer | Ownership Statement
31-Mar-08 | 0
31-Mar-08 | SILVERSTEIN JONATHAN
Director | Ownership Statement
23-Jul-08 | 5,555,556
23-Jul-08 | UTTERBERG DAVID S
Director | Acquisition (Non Open Market)
30-Jun-08 | 8,485,309
30-Jun-08 |
|
0.46% Nasdaq 
Insider Roster
