| Individual/Entity | Most Recent Trans. | Shares Owned as of Trans. Date | 14159 CAPITAL (GP), LLC
Beneficial Owner (10% or more) | Purchase
19-Dec-08 | 70,036
19-Dec-08 | ANDREEFF DANE
Beneficial Owner (10% or more) | Purchase
9-Jan-08 | Not Reported
| BAKER / TISCH CAPITAL (GP), LLC
Beneficial Owner (10% or more) | Purchase
19-Dec-08 | 95,646
19-Dec-08 | BAKER BIOTECH CAPITAL (GP), LLC
Beneficial Owner (10% or more) | Purchase
19-Dec-08 | 1,646,964
19-Dec-08 | BAKER BROS. CAPITAL (GP), LLC
Beneficial Owner (10% or more) | Disposition (Non Open Market)
23-Jan-09 | 136,010
23-Jan-09 | BAKER BROTHERS LIFE SCIENCES CAPITAL (GP), LLC
Beneficial Owner (10% or more) | Purchase
19-Dec-08 | 3,193,943
19-Dec-08 | BECK JOHN W
Officer | Option Exercise
14-Aug-09 | 885
14-Aug-09 | FUCHS HENRY J
Director | Option Exercise
12-Oct-09 | 10,416
12-Oct-09 | HICKEY DENIS
Officer | Sale
13-Dec-07 | 0
13-Dec-07 | KRUEGER CHRISTOPHER W
Officer | Option Exercise
23-Oct-09 | 0
23-Oct-09 | MANHARD KIMBERLY
Officer | Option Exercise
27-Nov-09 | 7,325
27-Nov-09 | POYHONEN JOHN
Director | Option Exercise
20-May-09 | 0
20-May-09 | QUART BARRY D
Officer | Option Exercise
9-Nov-09 | 39,011
9-Nov-09 | REMINGTON JACK
Director | Option Exercise
20-May-09 | 1,000
20-May-09 | TANG KEVIN C
Director | Purchase
17-Dec-08 | 3,320,112
17-Dec-08 |
|
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