| Individual/Entity | Most Recent Trans. | Shares Owned as of Trans. Date |
BANSAL AJAY Officer | Disposition (Non Open Market) 16-Oct-08 | 0 16-Oct-08 |
BARKAS ALEXANDER E Director | Disposition (Non Open Market) 16-Oct-08 | 0 16-Oct-08 |
CLARK ROSS G Officer | Acquisition (Non Open Market) 25-Mar-08 | 80,337 25-Mar-08 |
EASTHAM KARIN Director | Disposition (Non Open Market) 16-Oct-08 | 0 16-Oct-08 |
GRETHLEIN ANDREW J Officer | Disposition (Non Open Market) 16-Oct-08 | 0 16-Oct-08 |
HASNAIN FAHEEM Director | Ownership Statement 27-Feb-08 | 0 27-Feb-08 |
IPSEN, S.A. Beneficial Owner (10% or more) | Acquisition (Non Open Market) 22-Jul-08 | 16,653,533 22-Jul-08 |
JEAN CHRISTOPHE Director | Disposition (Non Open Market) 16-Oct-08 | 0 16-Oct-08 |
KING RICHARD Officer | Disposition (Non Open Market) 16-Oct-08 | 0 16-Oct-08 |
LESCHLY MARK Director | Disposition (Non Open Market) 16-Oct-08 | 0 16-Oct-08 |
MAHONEY DAVID L Director | Disposition (Non Open Market) 16-Oct-08 | 0 16-Oct-08 |
ROSENFIELD STEPHEN Officer | Disposition (Non Open Market) 16-Oct-08 | 0 16-Oct-08 |
SCARLETT JOHN A Officer | Disposition (Non Open Market) 16-Oct-08 | 0 16-Oct-08 |
VON STEIN THORSTEN Officer | Disposition (Non Open Market) 16-Oct-08 | 0 16-Oct-08 |
WONG SUSAN Officer | Disposition (Non Open Market) 16-Oct-08 | 0 16-Oct-08 |