| Individual/Entity | Most Recent Trans. | Shares Owned as of Trans. Date | BERGHEIM OLAV Director | Acquisition (Non Open Market) 1-Aug-08 | 54,501 1-Aug-08 | BLAIR JAMES C Beneficial Owner (10% or more) | Sale 16-Jul-08 | 85,698 16-Jul-08 | BURGESS VINCENT J Officer | Option Exercise 27-Feb-09 | 121,492 27-Feb-09 | DAHLDORF JOHN T Officer | Option Exercise 27-Feb-09 | 4,043 27-Feb-09 | DOMAIN ASSOCIATES Beneficial Owner (10% or more) | Acquisition (Non Open Market) 24-Apr-08 | 56,718 24-Apr-08 | DOMAIN PARTNERS IV LP Beneficial Owner (10% or more) | Disposition (Non Open Market) 16-Jul-08 | 1,868,540 16-Jul-08 | DOMAIN PARTNERS V LP Beneficial Owner (10% or more) | Disposition (Non Open Market) 16-Jul-08 | 2,646,328 16-Jul-08 | DOVEY BRIAN H Beneficial Owner (10% or more) | Sale 16-Jul-08 | 14,782 16-Jul-08 | DP IV ASSOCIATES LP Beneficial Owner (10% or more) | Sale 16-Jul-08 | 14,782 16-Jul-08 | DP V ASSOCIATES LP Beneficial Owner (10% or more) | Sale 16-Jul-08 | 62,513 16-Jul-08 | HALAK BRIAN K Beneficial Owner (10% or more) | Acquisition (Non Open Market) 24-Apr-08 | 60,133 24-Apr-08 | HUENNEKENS R SCOTT Officer | Option Exercise 10-Aug-09 | 20,000 10-Aug-09 | LUKIANOV ALEXIS V Director | Purchase 12-May-09 | 10,000 12-May-09 | LUSSIER MICHEL E Officer | Option Exercise 17-Apr-09 | 2,813 17-Apr-09 | MORE ROBERT J Beneficial Owner (10% or more) | Sale 16-Jul-08 | 79,351 16-Jul-08 | QUINOY JORGE J Officer | Option Exercise 27-Feb-09 | 9,317 27-Feb-09 | SCHOEMAKER KATHLEEN K Beneficial Owner (10% or more) | Sale 16-Jul-08 | 44,669 16-Jul-08 | SHERIDAN JOHN F Officer | Option Exercise 27-Feb-09 | 3,026 27-Feb-09 | TANAKA ROY T Director | Purchase 15-Jun-09 | 5,000
15-Jun-09 | TREU JESSE I Beneficial Owner (10% or more) | Sale 16-Jul-08 | 36,071 16-Jul-08 | VITULLO NICOLE Beneficial Owner (10% or more) | Acquisition (Non Open Market) 28-Apr-08 | 61,860 28-Apr-08 |
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