| Individual/Entity | Most Recent Trans. | Shares Owned as of Trans. Date | BB BIOVENTURES L P
Other | Sale
19-Jun-08 | 2,118,331
19-Jun-08 | BERREY M MICHELLE
Officer | Option Exercise
20-Jun-08 | 2,976
20-Jun-08 | BURRILL STEVEN
Director | Acquisition (Non Open Market)
24-Mar-09 | 4,000
24-Mar-09 | CARNEY WILLIAM J
Director | Acquisition (Non Open Market)
24-Mar-09 | 61,166
24-Mar-09 | CONRAD HERBERT J
Director | Acquisition (Non Open Market)
24-Mar-09 | 4,000
24-Mar-09 | EVNIN LUKE
Other | Sale
23-Jun-08 | 2,089,394
23-Jun-08 | GADICKE ANSBERT
Beneficial Owner (10% or more) | Sale
16-Jun-08 | 0
16-Jun-08 | GALAKATOS NICHOLAS
Beneficial Owner (10% or more) | Sale
21-Feb-08 | 0
21-Feb-08 | HAHN ELLIOT F
Director | Acquisition (Non Open Market)
24-Mar-09 | 17,333
24-Mar-09 | HENNER DENNIS
Beneficial Owner (10% or more) | Sale
2-Apr-08 | 0
2-Apr-08 | INOUYE MICHAEL K
Director | Acquisition (Non Open Market)
24-Mar-09 | 6,500
24-Mar-09 | LEUTZINGER KURT
Officer | Purchase
13-Mar-08 | 207,250
13-Mar-08 | LUBETKIN PAUL
Officer | Purchase
25-Feb-09 | 500
25-Feb-09 | MPM BIOVENTURES III-QP L.P.
Beneficial Owner (10% or more) | Sale
8-Feb-08 | 4,061
8-Feb-08 | OTTO MICHAEL J.
Officer | Option Exercise
18-Sep-09 | 2,410
18-Sep-09 | PRICE FREDRIC D
Director | Option Exercise
4-Dec-09 | 28,998
4-Dec-09 | QVT ASSOCIATES GP LLC
Beneficial Owner (10% or more) | Sale
24-Sep-09 | 2,793,274
24-Sep-09 | ROGERS MICHAEL D.
Officer | Option Exercise
13-Nov-08 | 0
13-Nov-08 | SIMON NICHOLAS J III
Beneficial Owner (10% or more) | Sale
2-Apr-08 | 0
2-Apr-08 | WILLIAMSON ROBERT F III
Director | Acquisition (Non Open Market)
24-Mar-09 | 10,666
24-Mar-09 |
|
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