| Individual/Entity | Most Recent Trans. | Shares Owned as of Trans. Date | ANIDO ARMANDO Director | Acquisition (Non Open Market) 12-May-09 | 6,013 12-May-09 | BVF PARTNERS L P/IL Beneficial Owner (10% or more) | Sale 22-Sep-09 | 10,338,102 22-Sep-09 | DOUGHERTY MICHAEL R Officer | Acquisition (Non Open Market) 15-Dec-09 | 329,411 15-Dec-09 | GEMAYEL GEORGES Director | Acquisition (Non Open Market) 12-May-09 | 4,448 12-May-09 | GODDARD PAUL Director | Acquisition (Non Open Market) 12-May-09 | 2,183 12-May-09 | HAGER GEORGE V JR Director | Acquisition (Non Open Market) 12-May-09 | 8,007 12-May-09 | HESS THOMAS P Officer | Option Exercise 20-May-08 | 6,247 20-May-08 | JACKSON DAVID Officer | Option Exercise 20-May-08 | 7,355 20-May-08 | LIMONGELLI JOHN M Officer | Acquisition (Non Open Market) 15-Dec-09 | 60,000 15-Dec-09 | MADDEN DAVID Director | Acquisition (Non Open Market) 12-May-09 | 820,461 12-May-09 | MAGNI GUIDO Director | Acquisition (Non Open Market) 12-May-09 | 2,183 12-May-09 | MANNING MARTHA E Officer | Option Exercise 20-May-08 | 11,465 20-May-08 | MAURER GEORGE R Officer | Acquisition (Non Open Market) 15-Dec-09 | 67,530 15-Dec-09 | NASH CLAUDE Director | Acquisition (Non Open Market) 12-May-09 | 36,672 12-May-09 | NICKELSON DONALD E Director | Acquisition (Non Open Market) 12-May-09 | 105,107 12-May-09 | SALINAS ELISEO ORESTE Officer | Acquisition (Non Open Market) 15-Dec-09 | 80,000 15-Dec-09 | WEBSTER STEPHEN W Officer | Acquisition (Non Open Market) 15-Dec-09 | 45,000 15-Dec-09 |
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