| Individual/Entity | Most Recent Trans. | Shares Owned as of Trans. Date | 14159 CAPITAL (GP), LLC Beneficial Owner (10% or more) | Sale 6-Feb-09 | 190,917
6-Feb-09 | BAKER / TISCH CAPITAL (GP), LLC Beneficial Owner (10% or more) | Sale 6-Feb-09 | 72,035
6-Feb-09 | BAKER BIOTECH CAPITAL (GP), LLC Beneficial Owner (10% or more) | Sale 6-Feb-09 | 2,022,293
6-Feb-09 | BAKER BROS. CAPITAL (GP), LLC Beneficial Owner (10% or more) | Sale 6-Feb-09 | 1,629
6-Feb-09 | BAKER BROTHERS LIFE SCIENCES CAPITAL (GP), LLC Beneficial Owner (10% or more) | Sale 6-Feb-09 | 5,771,961
6-Feb-09 | BAKER JULIAN Beneficial Owner (10% or more) | Sale 6-Feb-09 | 5,417
6-Feb-09 | BENNETT BRUCE K JR Officer | Purchase 30-Jun-09 | 6,322 30-Jun-09 | BERNS PAUL L Officer | Option Exercise 10-Aug-09 | 231,907 10-Aug-09 | CAGNONI PABLO J Officer | Disposition (Non Open Market) 30-Sep-09 | 25,200 30-Sep-09 | CARUSO JAMES V Officer | Option Exercise 10-Aug-09 | 88,873 10-Aug-09 | CLARK DAVID C Officer | Option Exercise 13-Mar-09 | 7,132 13-Mar-09 | GRABOYES MARC H Officer | Option Exercise 3-Aug-09 | 20,060 3-Aug-09 | HEN STEWART Director | Purchase 29-May-08 | 26,124,430
29-May-08 | HOFFMAN STEPHEN J Director | Option Exercise 4-Feb-09 | 474,870 4-Feb-09 | JOHNSON DOUGLAS G Officer | Option Exercise 7-Jan-08 | 32,467 7-Jan-08 | LEFF JONATHAN S Director | Purchase 29-May-08 | 26,124,430
29-May-08 | WARBURG PINCUS PRIVATE EQUITY VIII L P Director | Purchase 29-May-08 | 26,124,430 29-May-08 |
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