| Individual/Entity | Most Recent Trans. | Shares Owned as of Trans. Date |
|---|
HEALY JAMES
Director | Option Exercise
Jan 27, 2012 | 77,412
Jan 27, 2012 | HENNEY CHRISTOPHER S
Director | Purchase
Jun 28, 2012 | 302,429
Jun 28, 2012 | HISLOP COLIN
Officer | Acquisition (Non Open Market)
Mar 24, 2013 | 144,091
Mar 24, 2013 | KILFOIL GEORGINA
Officer | Disposition (Non Open Market)
Jan 2, 2013 | 30,035
Jan 2, 2013 | LOWE CHRISTOPHER P.
Officer | Acquisition (Non Open Market)
Mar 24, 2013 | 108,915
Mar 24, 2013 | ODINK DEBRA
Officer | Acquisition (Non Open Market)
Mar 24, 2013 | 177,259
Mar 24, 2013 | ORBIMED ADVISORS LLC
Director | Purchase
Jan 29, 2013 | 7,462,000
Jan 29, 2013 | SOFINNOVA VENTURE PARTNERS VI L P
Beneficial Owner (10% or more) | Sale
Dec 29, 2011 | 44,969
Dec 29, 2011 | THOMPSON DAVID E.
Director | Disposition (Non Open Market)
Nov 6, 2011 | 7,758
Nov 6, 2011 | TRUEX PAUL F
Officer | Disposition (Non Open Market)
May 20, 2013 | 727,181
May 20, 2013 | VANTAGEPOINT VENTURE ASSOCIATES IV LLC
Beneficial Owner (10% or more) | Option Exercise
Jul 6, 2011 | 5,357,528
Jul 6, 2011 |
|
0.52%