| Individual/Entity | Most Recent Trans. | Shares Owned as of Trans. Date | BARABE TIMOTHY C Director | Acquisition (Non Open Market) 23-Nov-09 | 28,822 23-Nov-09 | BVF PARTNERS L P/IL Beneficial Owner (10% or more) | Sale 17-Sep-09 | 20,808,146 17-Sep-09 | CHAN THOMAS C K Officer | Acquisition (Non Open Market) 20-Jan-09 | 20,000 20-Jan-09 | LAWRENCE PETER S Officer | Acquisition (Non Open Market) 20-Jan-09 | 85,000 20-Jan-09 | LINDSAY RONALD M Director | Purchase 13-Nov-08 | 20,000 13-Nov-08 | LOBERG MICHAEL D Director | Acquisition (Non Open Market) 23-Nov-09 | 61,819 23-Nov-09 | PUCCI PAOLO Officer | Purchase 12-Nov-09 | 212,331 12-Nov-09 | SCHWARTZ BRIAN Officer | Acquisition (Non Open Market) 20-Jan-09 | 21,700 20-Jan-09 | WEISKOPF ROBERT J Officer | Acquisition (Non Open Market) 20-Jan-09 | 19,750 20-Jan-09 | ZENNER PATRICK J Director | Purchase 21-Nov-08 | 20,000 21-Nov-08 |
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