| Individual/Entity | Most Recent Trans. | Shares Owned as of Trans. Date | AUSTIN STEPHEN G Director | Acquisition (Non Open Market) 19-Feb-09 | 170,094 19-Feb-09 | CLARUS LIFESCIENCES I, L.P. Beneficial Owner (10% or more) | Ownership Statement 4-Apr-08 | 15,557,318 4-Apr-08 | KATKIN KEITH Officer | Disposition (Non Open Market) 13-Sep-09 | 543,827 13-Sep-09 | KAYE RANDALL Officer | Sale 15-Sep-09 | 398,307
15-Sep-09 | MATHEWS CHARLES Director | Acquisition (Non Open Market) 19-Feb-09 | 171,969
19-Feb-09 | MAZZO DAVID J Director | Acquisition (Non Open Market) 19-Feb-09 | 168,594 19-Feb-09 | MOORIN JAY Beneficial Owner (10% or more) | Sale 13-Oct-09 | 7,125,754
13-Oct-09 | OCAMPO CHRISTINE Officer | Purchase 24-Feb-09 | 126,900 24-Feb-09 | PODLESAK DENNIS Director | Acquisition (Non Open Market) 19-Feb-09 | 168,594 19-Feb-09 | VIVO VENTURES FUND VI, L.P. Beneficial Owner (10% or more) | Sale 11-Aug-09 | 16,381,356 11-Aug-09 | WHEELER CRAIG A Director | Acquisition (Non Open Market) 19-Feb-09 | 227,594 19-Feb-09 | WHITCUP SCOTT M Director | Acquisition (Non Open Market) 19-Feb-09 | 167,594 19-Feb-09 |
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