| Individual/Entity | Most Recent Trans. | Shares Owned as of Trans. Date | BAIRD LYNN G Officer | Disposition (Non Open Market) 24-Apr-08 | 18,412 24-Apr-08 | BORISY ALEXIS Officer | Automatic Sale 26-Jan-09 | 312,204 26-Jan-09 | BVF PARTNERS L P/IL Beneficial Owner (10% or more) | Purchase 5-Dec-08 | 12,437,871 5-Dec-08 | COLE JASON Officer | Automatic Sale 26-Jan-09 | 22,367 26-Jan-09 | FORRESTER ROBERT Officer | Automatic Sale 26-Jan-09 | 21,383 26-Jan-09 | GRAU DANIEL Officer | Disposition (Non Open Market) 26-Jan-08 | 34,125 26-Jan-08 | KEITH CURTIS T Officer | Disposition (Non Open Market) 26-Jan-08 | 65,485 26-Jan-08 |
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