| Individual/Entity | Most Recent Trans. | Shares Owned as of Trans. Date | 14159 CAPITAL (GP), LLC Director | Purchase 17-Aug-09 | 103,607
17-Aug-09 | BAKER / TISCH CAPITAL (GP), LLC Director | Purchase 21-May-09 | 194,161
21-May-09 | BAKER BIOTECH CAPITAL (GP), LLC Director | Purchase 17-Aug-09 | 1,253,653
17-Aug-09 | BAKER BROS. CAPITAL (GP), LLC Director | Purchase 17-Aug-09 | 194,184
17-Aug-09 | BAKER BROTHERS LIFE SCIENCES CAPITAL (GP), LLC Director | Purchase 17-Aug-09 | 3,826,820
17-Aug-09 | BAKER JOFFRE Officer | Automatic Sale 8-Dec-09 | 176,975 8-Dec-09 | COHEN FRED E Director | Option Exercise 19-Feb-08 | 48,552 19-Feb-08 | COLE G BRADLEY Officer | Automatic Sale 14-Dec-09 | 2,000 14-Dec-09 | POPOVITS KIMBERLY J Officer | Automatic Sale 15-Dec-09 | 313,506 15-Dec-09 | SCOTT RANDAL W Officer | Automatic Sale 11-Dec-09 | 1,880,646 11-Dec-09 | SHAK STEVEN Officer | Automatic Sale 21-Dec-09 | 388,278 21-Dec-09 |
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