| Individual/Entity | Most Recent Trans. | Shares Owned as of Trans. Date | 14159 CAPITAL (GP), LLC Beneficial Owner (10% or more) | Sale 29-Jul-08 | 12,867
29-Jul-08 | AGRAWAL SUDHIR Officer | Disposition (Non Open Market) 25-Jun-09 | 126,277 25-Jun-09 | BAKER BIOTECH CAPITAL (GP), LLC Beneficial Owner (10% or more) | Sale 29-Jul-08 | 209,110
29-Jul-08 | BAKER BROS. CAPITAL (GP), LLC Beneficial Owner (10% or more) | Sale 29-Jul-08 | 40,077
29-Jul-08 | BAKER BROTHERS LIFE SCIENCES CAPITAL (GP), LLC Beneficial Owner (10% or more) | Sale 29-Jul-08 | 418,030
29-Jul-08 | BEXON ALICE Officer | Option Exercise 14-Mar-08 | 0 14-Mar-08 | MUELLER HANS Director | Purchase 24-Nov-09 | 10,000 24-Nov-09 | REARDON WILLIAM S Director | Acquisition (Non Open Market) 1-Apr-09 | 5,233 1-Apr-09 | SULLIVAN TIMOTHY M Officer | Sale 15-May-08 | 18,966 15-May-08 | WYNGAARDEN JAMES B Director | Sale 12-Jun-08 | 36,685 12-Jun-08 | ZEIN YOUSSEF EL Director | Option Exercise 29-May-09 | 722,335 29-May-09 |
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