| Individual/Entity | Most Recent Trans. | Shares Owned as of Trans. Date | 14159 CAPITAL (GP), LLC Director | Acquisition (Non Open Market) 24-Sep-09 | 282,354
24-Sep-09 | BAKER / TISCH CAPITAL (GP), LLC Director | Acquisition (Non Open Market) 24-Sep-09 | 189,909
24-Sep-09 | BAKER BIOTECH CAPITAL (GP), LLC Director | Purchase 5-Mar-09 | 3,487,000
5-Mar-09 | BAKER BROS. CAPITAL (GP), LLC Director | Purchase 5-Mar-09 | 284,449
5-Mar-09 | BAKER BROTHERS LIFE SCIENCES CAPITAL (GP), LLC Director | Acquisition (Non Open Market) 24-Sep-09 | 8,929,705
24-Sep-09 | CHARDONNET LAURENT Other | Purchase 20-Nov-08 | 8,250 20-Nov-08 | DE SCHUTTER RICHARD U Director | Option Exercise 13-Nov-07 | 95,000 13-Nov-07 | FRIEDMAN PAUL A Officer | Purchase 9-Mar-09 | 254,565 9-Mar-09 | FRIEDMAN STEVEN M. Officer | Ownership Statement 27-Jan-09 | 54,389 27-Jan-09 | HASTINGS DAVID C Officer | Purchase 20-Nov-08 | 6,500 20-Nov-08 | METCALF BRIAN W Officer | Purchase 21-Nov-08 | 49,839 21-Nov-08 | SCHRECK PATRICIA A Officer | Purchase 20-Nov-08 | 4,500 20-Nov-08 | WHITFIELD ROY A Director | Disposition (Non Open Market) 27-Nov-07 | 971,335 27-Nov-07 |
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