| Individual/Entity | Most Recent Trans. | Shares Owned as of Trans. Date | BARTHELEMY NICOLAS Officer | Option Exercise 14-Nov-08 | 33,540 14-Nov-08 | BENCHIMOL CLAUDE Officer | Option Exercise 14-Nov-08 | 25,993 14-Nov-08 | BRUST BERND Officer | Option Exercise 14-Nov-08 | 5,381 14-Nov-08 | COTTINGHAM JOHN A Officer | Option Exercise 14-Nov-08 | 10,283 14-Nov-08 | GIBSON KAREN Officer | Option Exercise 25-Apr-08 | 3,240 25-Apr-08 | HOFFMEISTER DAVID F Officer | Option Exercise 14-Nov-08 | 56,680 14-Nov-08 | LEDDY PETER MICHAEL Officer | Option Exercise 14-Nov-08 | 57,414 14-Nov-08 | LUCIER GREGORY T Officer | Option Exercise 14-Nov-08 | 191,910
14-Nov-08 | MATRICARIA RONALD A Director | Purchase 18-Nov-08 | 60,000 18-Nov-08 | SHORT JAY M PHD Director | Option Exercise 1-May-08 | 3,500 1-May-08 | UPRICHARD DAVID C Director | Sale 19-Feb-08 | 2,900 19-Feb-08 |
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