| Individual/Entity | Most Recent Trans. | Shares Owned as of Trans. Date | BOZIGIAN HAIG P. Officer | Automatic Sale 28-Sep-09 | 35,781 28-Sep-09 | BVF PARTNERS L P/IL Beneficial Owner (10% or more) | Purchase 23-Jan-09 | 8,047,547 23-Jan-09 | COUGHLIN TIMOTHY P Officer | Automatic Sale 30-Mar-09 | 43,790 30-Mar-09 | GORMAN KEVIN CHARLES Officer | Automatic Sale 30-Mar-09 | 109,322 30-Mar-09 | GRIGORIADIS DIMITRI E. Officer | Automatic Sale 28-Sep-09 | 33,210 28-Sep-09 | MITCHELL W THOMAS Director | Purchase 5-Nov-09 | 1,900
5-Nov-09 | OBRIEN CHRISTOPHER FLINT Officer | Automatic Sale 28-Sep-09 | 52,106 28-Sep-09 | RANIERI RICHARD J Officer | Automatic Sale 12-Feb-08 | 9,667 12-Feb-08 | VALEUR JENSEN MARGARET E Officer | Automatic Sale 30-Mar-09 | 61,762 30-Mar-09 |
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