| Individual/Entity | Most Recent Trans. | Shares Owned as of Trans. Date | BAKER / TISCH CAPITAL (GP), LLC Director | Acquisition (Non Open Market) 25-Jul-08 | 335,668
25-Jul-08 | BAKER BIOTECH CAPITAL (GP), LLC Director | Acquisition (Non Open Market) 25-Jul-08 | 3,500,059
25-Jul-08 | BAKER BROS. CAPITAL (GP), LLC Director | Acquisition (Non Open Market) 25-Jul-08 | 690,856
25-Jul-08 | BAKER BROTHERS LIFE SCIENCES CAPITAL (GP), LLC Director | Acquisition (Non Open Market) 25-Jul-08 | 3,678,823
25-Jul-08 | HEN STEWART Director | Acquisition (Non Open Market) 25-Jul-08 | 13,571,441
25-Jul-08 | LAMATTINA JOHN L Director | Ownership Statement 14-Feb-08 | 0 14-Feb-08 | LEFF JONATHAN S Director | Acquisition (Non Open Market) 25-Jul-08 | 13,571,411
25-Jul-08 | PITLER THOMAS A. Officer | Ownership Statement 17-Apr-08 | 17,189
17-Apr-08 | SIMON JOHN Director | Acquisition (Non Open Market) 25-Jul-08 | 308,494 25-Jul-08 | WARBURG PINCUS PRIVATE EQUITY VIII L P Director | Acquisition (Non Open Market) 25-Jul-08 | 13,571,411 25-Jul-08 |
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