| Individual/Entity | Most Recent Trans. | Shares Owned as of Trans. Date |
AUSTIN JOSIAH T Beneficial Owner (10% or more) | Purchase 24-Sep-08 | 4,109,964
24-Sep-08 |
BARTLETT PAUL A Director | Disposition (Non Open Market) 23-Dec-08 | 0 23-Dec-08 |
BELDER RENE Officer | Disposition (Non Open Market) 23-Dec-08 | 0 23-Dec-08 |
BROWNE LESLIE J Officer | Acquisition (Non Open Market) 30-Apr-08 | 14,549 30-Apr-08 |
BVF PARTNERS L P/IL Beneficial Owner (10% or more) | Purchase 5-Nov-08 | 6,186,839 5-Nov-08 |
COSTALAS STEPHEN C Officer | Disposition (Non Open Market) 23-Dec-08 | 0 23-Dec-08 |
EL CORONADO HOLDINGS, LLC Beneficial Owner (10% or more) | Ownership Statement 13-Oct-08 | 4,070,164 13-Oct-08 |
FLOYD DAVID M Officer | Acquisition (Non Open Market) 31-Mar-08 | 5,085 31-Mar-08 |
KIMBALL DAVID Officer | Acquisition (Non Open Market) 29-Aug-08 | 37,011 29-Aug-08 |
LIEBLER ERIC J Officer | Acquisition (Non Open Market) 30-May-08 | 56,048 30-May-08 |
MOLLICA JOSEPH A Officer | Disposition (Non Open Market) 23-Dec-08 | 0 23-Dec-08 |
POSNER BRIAN M Officer | Disposition (Non Open Market) 23-Dec-08 | 0 23-Dec-08 |
SOETERS MARTINUS HERMANUS Director | Disposition (Non Open Market) 23-Dec-08 | 0 23-Dec-08 |
TOMLINSON SIMON M Officer | Acquisition (Non Open Market) 30-Apr-08 | 6,130 30-Apr-08 |
WEBB MARIA L Officer | Disposition (Non Open Market) 23-Dec-08 | 0 23-Dec-08 |