| Individual/Entity | Most Recent Trans. | Shares Owned as of Trans. Date | 14159 CAPITAL (GP), LLC
Director | Purchase
20-May-09 | 171,479
20-May-09 | AKKARAJU SRINIVAS
Director | Purchase
18-Aug-09 | 36,433
18-Aug-09 | BAKER / TISCH CAPITAL (GP), LLC
Director | Purchase
20-May-09 | 400,898
20-May-09 | BAKER BIOTECH CAPITAL (GP), LLC
Director | Purchase
20-May-09 | 4,352,809
20-May-09 | BAKER BROS. CAPITAL (GP), LLC
Director | Purchase
20-May-09 | 481,092
20-May-09 | BAKER BROTHERS LIFE SCIENCES CAPITAL (GP), LLC
Director | Purchase
20-May-09 | 8,684,009
20-May-09 | BERGER FRANKLIN M
Director | Option Exercise
7-Oct-09 | 82,220
7-Oct-09 | DOBMEIER ERIC
Officer | Option Exercise
29-Oct-09 | 19,609
29-Oct-09 | GRYSKA DAVID W
Director | Option Exercise
20-Jul-09 | 17,500
20-Jul-09 | H&Q HOLDINGS, INC.
Beneficial Owner (10% or more) | Sale
28-Jul-08 | 25,052
28-Jul-08 | JP MORGAN PARTNERS BHCA LP
Beneficial Owner (10% or more) | Sale
28-Jul-08 | 25,052
28-Jul-08 | LIPPMAN MARC E
Director | Option Exercise
14-Dec-07 | 77,500
14-Dec-07 | REYNOLDS THOMAS C
Officer | Option Exercise
30-Jul-09 | 3,713
30-Jul-09 | ROSENBERG MORRIS
Officer | Option Exercise
28-Jul-09 | 0
28-Jul-09 | SIEGALL CLAY B
Officer | Option Exercise
8-Sep-09 | 978,168
8-Sep-09 |
|
1.48% Nasdaq 
Insider Roster
