| Individual/Entity | Most Recent Trans. | Shares Owned as of Trans. Date | BAVP, L.P. Beneficial Owner (10% or more) | Purchase 8-Jul-09 | 2,492,220 8-Jul-09 | BOXER CAPITAL, LLC Other | Sale 26-Aug-09 | 876,489 26-Aug-09 | COBB TERRELL Director | Acquisition (Non Open Market) 30-Sep-09 | 50,914 30-Sep-09 | DORSEY BRIAN Officer | Automatic Sale 1-May-09 | 17,212 1-May-09 | DUBE SUSAN Officer | Acquisition (Non Open Market) 17-Feb-09 | 76,386 17-Feb-09 | EAGLE MICHAEL L Director | Acquisition (Non Open Market) 30-Sep-09 | 50,339 30-Sep-09 | EMSTER KURT VON Director | Acquisition (Non Open Market) 30-Sep-09 | 85,690 30-Sep-09 | EVNIN LUKE Beneficial Owner (10% or more) | Purchase 8-Jul-09 | 4,632,562
8-Jul-09 | HALE DAVID F Director | Acquisition (Non Open Market) 30-Sep-09 | 246,879 30-Sep-09 | JOCHELSON PHILIP Officer | Acquisition (Non Open Market) 28-Nov-08 | 52,500 28-Nov-08 | JONES ROBERT LEWIS Officer | Acquisition (Non Open Market) 17-Feb-09 | 65,429 17-Feb-09 | LITALIEN JAMES J Officer | Acquisition (Non Open Market) 17-Feb-09 | 64,164 17-Feb-09 | MAST ERLE T Director | Acquisition (Non Open Market) 30-Sep-09 | 54,448 30-Sep-09 | MCGILLEY MEG Officer | Acquisition (Non Open Market) 17-Feb-09 | 74,721 17-Feb-09 | MONTREUX EQUITY PARTNERS II SBIC LP Beneficial Owner (10% or more) | Acquisition (Non Open Market) 8-Jul-09 | 2,195,505 8-Jul-09 | MPM BIOVENTURES III QP LP Beneficial Owner (10% or more) | Purchase 8-Jul-09 | 4,632,562
8-Jul-09 | ONAITIS MATTHEW Officer | Acquisition (Non Open Market) 17-Feb-09 | 74,560 17-Feb-09 | PASCOE RICHARD W Officer | Acquisition (Non Open Market) 17-Feb-09 | 105,872 17-Feb-09 | RASER JEFFREY Officer | Purchase 21-May-09 | 25,000 21-May-09 | TREU JESSE I Director | Acquisition (Non Open Market) 30-Sep-09 | 1,345,226 30-Sep-09 | WHEELER KURT Director | Acquisition (Non Open Market) 30-Sep-09 | 4,680,564 30-Sep-09 | WIGGANS THOMAS G Director | Acquisition (Non Open Market) 30-Sep-09 | 46,667 30-Sep-09 |
|