| Individual/Entity | Most Recent Trans. | Shares Owned as of Trans. Date | BAVP, L.P.
Beneficial Owner (10% or more) | Purchase
8-Jul-09 | 2,492,220
8-Jul-09 | BOXER CAPITAL, LLC
Other | Sale
26-Aug-09 | 876,489
26-Aug-09 | COBB TERRELL
Director | Acquisition (Non Open Market)
31-Dec-09 | 59,479
31-Dec-09 | DORSEY BRIAN
Officer | Automatic Sale
1-May-09 | 17,212
1-May-09 | DUBE SUSAN
Officer | Acquisition (Non Open Market)
17-Feb-09 | 76,386
17-Feb-09 | EAGLE MICHAEL L
Director | Acquisition (Non Open Market)
31-Dec-09 | 60,640
31-Dec-09 | EMSTER KURT VON
Director | Acquisition (Non Open Market)
30-Sep-09 | 85,690
30-Sep-09 | EVNIN LUKE
Beneficial Owner (10% or more) | Purchase
8-Jul-09 | 4,632,562
8-Jul-09 | HALE DAVID F
Director | Acquisition (Non Open Market)
31-Dec-09 | 272,805
31-Dec-09 | JOCHELSON PHILIP
Officer | Acquisition (Non Open Market)
28-Nov-08 | 52,500
28-Nov-08 | JONES ROBERT LEWIS
Officer | Acquisition (Non Open Market)
17-Feb-09 | 65,429
17-Feb-09 | LITALIEN JAMES J
Officer | Acquisition (Non Open Market)
17-Feb-09 | 64,164
17-Feb-09 | MAST ERLE T
Director | Acquisition (Non Open Market)
30-Sep-09 | 54,448
30-Sep-09 | MCGILLEY MEG
Officer | Acquisition (Non Open Market)
17-Feb-09 | 74,721
17-Feb-09 | MONTREUX EQUITY PARTNERS II SBIC LP
Beneficial Owner (10% or more) | Acquisition (Non Open Market)
8-Jul-09 | 2,195,505
8-Jul-09 | MPM BIOVENTURES III-QP L.P.
Beneficial Owner (10% or more) | Purchase
8-Jul-09 | 4,632,562
8-Jul-09 | ONAITIS MATTHEW
Officer | Acquisition (Non Open Market)
17-Feb-09 | 74,560
17-Feb-09 | PASCOE RICHARD W
Officer | Acquisition (Non Open Market)
17-Feb-09 | 105,872
17-Feb-09 | RASER JEFFREY
Officer | Sale
8-Dec-09 | 118,834
8-Dec-09 | TREU JESSE I
Director | Acquisition (Non Open Market)
31-Dec-09 | 52,318
31-Dec-09 | WHEELER KURT
Director | Acquisition (Non Open Market)
31-Dec-09 | 4,689,939
31-Dec-09 | WIGGANS THOMAS G
Director | Acquisition (Non Open Market)
30-Sep-09 | 46,667
30-Sep-09 |
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