| Individual/Entity | Most Recent Trans. | Shares Owned as of Trans. Date | ALTA BIOPHARMA PARTNERS III LP Other | Purchase 5-Oct-09 | 1,536,625 5-Oct-09 | ANDERSON DAVID L Beneficial Owner (10% or more) | Purchase 5-Oct-09 | 64,199
5-Oct-09 | BAKER G LEONARD JR Beneficial Owner (10% or more) | Purchase 5-Oct-09 | 77,421
5-Oct-09 | BIRD JEFFREY W Director | Purchase 5-Oct-09 | 111,116
5-Oct-09 | COXE TENCH Beneficial Owner (10% or more) | Purchase 5-Oct-09 | 155,090
5-Oct-09 | CURD JOHN G Officer | Purchase 2-Nov-09 | 80,759 2-Nov-09 | FRAZIER HEALTHCARE VI, L.P. Beneficial Owner (10% or more) | Ownership Statement 5-Oct-09 | 7,853,402 5-Oct-09 | GAITHER JAMES C Beneficial Owner (10% or more) | Purchase 5-Oct-09 | 23,801
5-Oct-09 | HEALTHCARE VENTURES VIII, L.P. Beneficial Owner (10% or more) | Purchase 5-Oct-09 | 3,041,268
5-Oct-09 | JAEGER WILFRED E Director | Purchase 5-Oct-09 | 2,310,023
5-Oct-09 | SANDS GREGORY P Beneficial Owner (10% or more) | Purchase 5-Oct-09 | 75,673
5-Oct-09 | SELICK HAROLD E Officer | Purchase 5-Oct-09 | 312,670 5-Oct-09 | SHEEHAN ANDREW T Beneficial Owner (10% or more) | Purchase 5-Oct-09 | 42,480
5-Oct-09 | SUTTER HILL VENTURES Beneficial Owner (10% or more) | Purchase 5-Oct-09 | 3,678,983 5-Oct-09 | SWEET DAVID E Beneficial Owner (10% or more) | Purchase 5-Oct-09 | 28,364
5-Oct-09 | TANG KEVIN C Beneficial Owner (10% or more) | Ownership Statement 29-Sep-08 | 1,405,704 29-Sep-08 | WHITE JAMES N Beneficial Owner (10% or more) | Purchase 5-Oct-09 | 117,392
5-Oct-09 | YOUNGER WILLIAM H JR Beneficial Owner (10% or more) | Purchase 5-Oct-09 | 130,713
5-Oct-09 |
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