| Insider Transactions Reported - Last Two Years |
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| Date | Insider | Shares | Type | Transaction | Value* |
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| May 14, 2013 | BAKER FELIXDirector | 1,993,000 | Indirect | Purchase at $12.50 per share. | 24,912,500 | | May 1, 2013 | HACKSELL ULIOfficer | 20,449 | Direct | Disposition (Non Open Market) at $0 per share. | N/A | | May 1, 2013 | HACKSELL ULIOfficer | 20,449 | Indirect | Acquisition (Non Open Market) at $0 per share. | N/A | | May 1, 2013 | HACKSELL ULIOfficer | 20,449 | Direct | Option Exercise at $1.08 per share. | 22,084 | | May 1, 2013 | HACKSELL ULIOfficer | 20,449 | Indirect | Automatic Sale at $12.34 per share. | 252,340 | | Apr 30, 2013 | HACKSELL ULIOfficer | 19,551 | Indirect | Automatic Sale at $12.71 per share. | 248,493 | | Apr 30, 2013 | HACKSELL ULIOfficer | 19,551 | Direct | Option Exercise at $1.08 per share. | 21,115 | | Apr 30, 2013 | HACKSELL ULIOfficer | 19,551 | Indirect | Acquisition (Non Open Market) at $0 per share. | N/A | | Apr 30, 2013 | HACKSELL ULIOfficer | 19,551 | Direct | Disposition (Non Open Market) at $0 per share. | N/A | | Apr 21, 2013 | BAITY GLENNOfficer | 10,000 | Direct | Automatic Sale at $13.15 per share. | 131,500 | | Apr 21, 2013 | BAITY GLENNOfficer | 10,000 | Direct | Option Exercise at $1.62 per share. | 16,200 | | Apr 16, 2013 | BAITY GLENNOfficer | 10,000 | Direct | Option Exercise at $1.55 per share. | 15,500 | | Apr 16, 2013 | BAITY GLENNOfficer | 10,000 | Direct | Automatic Sale at $12.26 per share. | 122,600 | | Apr 15, 2013 | HACKSELL ULIOfficer | 16,729 | Direct | Option Exercise at $1.08 per share. | 18,067 | | Apr 15, 2013 | HACKSELL ULIOfficer | 16,729 | Direct | Disposition (Non Open Market) at $0 per share. | N/A | | Apr 15, 2013 | HACKSELL ULIOfficer | 16,729 | Indirect | Acquisition (Non Open Market) at $0 per share. | N/A | | Apr 15, 2013 | BAITY GLENNOfficer | 20,000 | Direct | Automatic Sale at $12.30 per share. | 246,000 | | Apr 15, 2013 | HACKSELL ULIOfficer | 16,729 | Indirect | Automatic Sale at $12.32 per share. | 206,101 | | Apr 15, 2013 | BAITY GLENNOfficer | 20,000 | Direct | Option Exercise at $1.55 per share. | 31,000 | | Apr 14, 2013 | BAITY GLENNOfficer | 20,000 | Direct | Automatic Sale at $12.50 per share. | 250,000 | | Apr 14, 2013 | BAITY GLENNOfficer | 20,000 | Direct | Option Exercise at $1.55 per share. | 31,000 | | Apr 11, 2013 | BAITY GLENNOfficer | 30,000 | Direct | Automatic Sale at $12.74 - $13 per share. | 386,0002 | | Apr 11, 2013 | BAITY GLENNOfficer | 30,000 | Direct | Option Exercise at $1.55 - $1.62 per share. | 48,0002 | | Apr 10, 2013 | BAITY GLENNOfficer | 30,000 | Direct | Option Exercise at $1.55 - $1.62 per share. | 48,0002 | | Apr 10, 2013 | BAITY GLENNOfficer | 30,000 | Direct | Automatic Sale at $11.06 - $13 per share. | 361,0002 | | Apr 10, 2013 | AASEN THOMAS HOfficer | 40,000 | Direct | Disposition (Non Open Market) at $0 per share. | N/A | | Apr 10, 2013 | AASEN THOMAS HOfficer | 40,000 | Indirect | Acquisition (Non Open Market) at $0 per share. | N/A | | Apr 10, 2013 | AASEN THOMAS HOfficer | 34,029 | Direct | Option Exercise at $1.08 - $2 per share. | N/A | | Apr 10, 2013 | AASEN THOMAS HOfficer | 40,000 | Indirect | Automatic Sale at $11.06 per share. | 442,400 | | Apr 1, 2013 | BAITY GLENNOfficer | 13,163 | Direct | Automatic Sale at $8 per share. | 105,304 | | Mar 31, 2013 | AASEN THOMAS HOfficer | 40,000 | Direct | Option Exercise at $1.08 per share. | 43,200 | | Mar 31, 2013 | AASEN THOMAS HOfficer | 40,000 | Direct | Disposition (Non Open Market) at $0 per share. | N/A | | Mar 31, 2013 | HACKSELL ULIOfficer | 40,000 | Direct | Option Exercise at $1.08 per share. | 43,200 | | Mar 31, 2013 | AASEN THOMAS HOfficer | 40,000 | Indirect | Acquisition (Non Open Market) at $0 per share. | N/A | | Mar 31, 2013 | AASEN THOMAS HOfficer | 40,000 | Indirect | Automatic Sale at $7.68 per share. | 307,200 | | Mar 31, 2013 | HACKSELL ULIOfficer | 40,000 | Direct | Disposition (Non Open Market) at $0 per share. | N/A | | Mar 31, 2013 | HACKSELL ULIOfficer | 40,000 | Indirect | Acquisition (Non Open Market) at $0 per share. | N/A | | Mar 31, 2013 | HACKSELL ULIOfficer | 40,000 | Indirect | Automatic Sale at $7.68 per share. | 307,200 | | Mar 31, 2013 | MILLS ROGEROfficer | 58,584 | Direct | Automatic Sale at $7.69 per share. | 450,510 | | Feb 20, 2013 | IVERSEN LESLIE LDirector | 4,500 | Direct | Option Exercise at $0 per share. | N/A | | Jan 17, 2013 | 14159, L.P.Director | 346,725 | Direct | Statement of Ownership | N/A | | Jan 17, 2013 | BAKER BROTHERS LIFE SCIENCES LPDirector | 14,229,612 | Direct | Statement of Ownership | N/A | | Jan 17, 2013 | HACKSELL ULIOfficer | 7,500 | Indirect | Acquisition (Non Open Market) at $0 per share. | N/A | | Jan 17, 2013 | HACKSELL ULIOfficer | 7,500 | Direct | Disposition (Non Open Market) at $0 per share. | N/A | | Jan 17, 2013 | 667, L.P.Director | 1,045,475 | Direct | Statement of Ownership | N/A | | Jan 17, 2013 | HACKSELL ULIOfficer | 7,500 | Direct | Option Exercise at $0 per share. | N/A | | Jan 16, 2013 | AASEN THOMAS HOfficer | 12,000 | Direct | Option Exercise at $1.08 per share. | 12,960 | | Jan 13, 2013 | KAPLAN LESTER J PH DDirector | 4,500 | Direct | Option Exercise at $1.08 per share. | 4,860 | | Jan 9, 2013 | RASMUSSEN TORSTENDirector | 4,500 | Indirect | Option Exercise at $1.08 per share. | 4,860 | | Dec 11, 2012 | BAKER BROS ADVISORS LLCBeneficial Owner (10% or more) | 14,229,612 | Indirect | Statement of Ownership | N/A | | Nov 27, 2012 | AASEN THOMAS HOfficer | 5,000 | Indirect | Acquisition (Non Open Market) at $0 per share. | N/A | | Nov 27, 2012 | AASEN THOMAS HOfficer | 9,100 | Indirect | Automatic Sale at $5.25 per share. | 47,775 | | Nov 27, 2012 | AASEN THOMAS HOfficer | 5,000 | Direct | Option Exercise at $1.08 per share. | 5,400 | | Nov 27, 2012 | AASEN THOMAS HOfficer | 5,000 | Direct | Disposition (Non Open Market) at $0 per share. | N/A | | Nov 27, 2012 | BAITY GLENNOfficer | 4,396 | Direct | Automatic Sale at $5.25 per share. | 23,079 | | Nov 26, 2012 | AASEN THOMAS HOfficer | 33,631 | Indirect | Acquisition (Non Open Market) at $0 per share. | N/A | | Nov 26, 2012 | AASEN THOMAS HOfficer | 30,900 | Indirect | Automatic Sale at $6.24 per share. | 192,816 | | Nov 26, 2012 | AASEN THOMAS HOfficer | 33,631 | Direct | Disposition (Non Open Market) at $0 per share. | N/A | | Nov 26, 2012 | BAITY GLENNOfficer | 16,206 | Direct | Automatic Sale at $6.28 per share. | 101,773 | | Sep 6, 2012 | AASEN THOMAS HOfficer | 7,500 | Direct | Option Exercise at $1.50 per share. | 11,250 | | Aug 21, 2012 | HACKSELL ULIOfficer | 23,333 | Direct | Disposition (Non Open Market) at $0 per share. | N/A | | Aug 21, 2012 | HACKSELL ULIOfficer | 23,333 | Indirect | Acquisition (Non Open Market) at $0 per share. | N/A | | Aug 21, 2012 | HACKSELL ULIOfficer | 23,333 | Direct | Option Exercise at $0 per share. | N/A | | Aug 2, 2012 | AASEN THOMAS HOfficer | 5,000 | Direct | Option Exercise at $1.50 per share. | 7,500 |
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| Data provided by EDGAR Online |
* = Where indicated, some values are estimates. 1= Potential proceeds estimated by the filer. 2= Estimated based on the average of multiple prices reported. 3= Multiple dates reported. Most recent date shown.
Currency in USD.
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