| Date | Insider | Shares | Type | Transaction | Value* |
| 22-Sep-09 | BVF PARTNERS L P/IL Beneficial Owner (10% or more) | 354,000 | Direct | Sale at $1.69 - $1.7 per share. | $600,0002 |
| 21-Sep-09 | BVF PARTNERS L P/IL Beneficial Owner (10% or more) | 53,000 | Direct | Sale at $1.67 per share. | $88,510 |
| 18-Sep-09 | BVF PARTNERS L P/IL Beneficial Owner (10% or more) | 241,000 | Direct | Sale at $1.66 per share. | $400,060 |
| 17-Sep-09 | BVF PARTNERS L P/IL Beneficial Owner (10% or more) | 108,000 | Direct | Sale at $1.70 per share. | $183,600 |
| 16-Sep-09 | BVF PARTNERS L P/IL Beneficial Owner (10% or more) | 138,000 | Direct | Sale at $1.71 per share. | $235,980 |
| 15-Sep-09 | BVF PARTNERS L P/IL Beneficial Owner (10% or more) | 355,000 | Direct | Sale at $1.72 per share. | $610,600 |
| 14-Sep-09 | BVF PARTNERS L P/IL Beneficial Owner (10% or more) | 95,000 | Direct | Sale at $1.79 per share. | $170,050 |
| 14-Jul-09 | BVF PARTNERS L P/IL Beneficial Owner (10% or more) | 25,000 | Direct | Sale at $1.67 per share. | $41,750 |
| 13-Jul-09 | BVF PARTNERS L P/IL Beneficial Owner (10% or more) | 700,500 | Direct | Sale at $1.67 per share. | $1,169,835 |
| 12-May-09 | MAGNI GUIDO Director | 2,183 | Direct | Acquisition (Non Open Market) at $0 per share. | N/A |
| 12-May-09 | NASH CLAUDE Director | 3,275 | Direct | Acquisition (Non Open Market) at $0 per share. | N/A |
| 12-May-09 | NICKELSON DONALD E Director | 2,183 | Direct | Acquisition (Non Open Market) at $0 per share. | N/A |
| 12-May-09 | GEMAYEL GEORGES Director | 2,183 | Direct | Acquisition (Non Open Market) at $0 per share. | N/A |
| 12-May-09 | ANIDO ARMANDO Director | 3,275 | Direct | Acquisition (Non Open Market) at $0 per share. | N/A |
| 12-May-09 | HAGER GEORGE V JR Director | 3,930 | Direct | Acquisition (Non Open Market) at $0 per share. | N/A |
| 12-May-09 | GODDARD PAUL Director | 2,183 | Direct | Acquisition (Non Open Market) at $0 per share. | N/A |
| 12-May-09 | MADDEN DAVID Director | 8,078 | Direct | Acquisition (Non Open Market) at $0 per share. | N/A |
| 22-Jan-09 | DOUGHERTY MICHAEL R Officer | 25,000 | Direct | Purchase at $1.90 per share. | $47,500 |
| 16-Jan-09 | DOUGHERTY MICHAEL R Officer | 26,100 | Direct | Purchase at $1.95 per share. | $50,895 |
| 9-Jan-09 | DOUGHERTY MICHAEL R Officer | 25,000 | Direct | Purchase at $1.85 per share. | $46,250 |
| 6-Jan-09 | MAURER GEORGE R Officer | 15,000 | Direct | Acquisition (Non Open Market) at $0 per share. | N/A |
| 6-Jan-09 | MAURER GEORGE R Officer | 7,530 | Direct | Statement of Ownership | N/A |
| 20-Nov-08 | DOUGHERTY MICHAEL R Officer | 25,000 | Direct | Purchase at $1.59 per share. | $39,750 |
| 31-Oct-08 | BVF PARTNERS L P/IL Beneficial Owner (10% or more) | 1,000 | Indirect | Purchase at $2.95 per share. | $2,950 |
| 30-Oct-08 | BVF PARTNERS L P/IL Beneficial Owner (10% or more) | 31,500 | Indirect | Purchase at $2.94 per share. | $92,610 |
| 29-Oct-08 | BVF PARTNERS L P/IL Beneficial Owner (10% or more) | 56,400 | Indirect | Purchase at $2.79 per share. | $157,356 |
| 28-Oct-08 | BVF PARTNERS L P/IL Beneficial Owner (10% or more) | 1,351,119 | Indirect | Purchase at $2.75 - $2.81 per share. | $3,756,0002 |
| 27-Oct-08 | BVF PARTNERS L P/IL Beneficial Owner (10% or more) | 64,400 | Indirect | Purchase at $3.12 per share. | $200,928 |
| 23-Oct-08 | BVF PARTNERS L P/IL Beneficial Owner (10% or more) | 132,300 | Indirect | Purchase at $3.22 per share. | $426,006 |
| 22-Oct-08 | BVF PARTNERS L P/IL Beneficial Owner (10% or more) | 71,400 | Indirect | Purchase at $3.24 per share. | $231,336 |
| 16-Oct-08 | BVF PARTNERS L P/IL Beneficial Owner (10% or more) | 18,900 | Indirect | Purchase at $3.12 per share. | $58,968 |
| 15-Oct-08 | BVF PARTNERS L P/IL Beneficial Owner (10% or more) | 51,000 | Indirect | Purchase at $3.08 per share. | $157,080 |
| 14-Oct-08 | BVF PARTNERS L P/IL Beneficial Owner (10% or more) | 8,500 | Indirect | Purchase at $3.15 per share. | $26,775 |
| 13-Oct-08 | BVF PARTNERS L P/IL Beneficial Owner (10% or more) | 48,500 | Indirect | Purchase at $3.24 per share. | $157,140 |
| 10-Oct-08 | BVF PARTNERS L P/IL Beneficial Owner (10% or more) | 4,428,032 | Indirect | Statement of Ownership | N/A |
| 10-Oct-08 | BVF PARTNERS L P/IL Beneficial Owner (10% or more) | 2,611,000 | Direct | Statement of Ownership | N/A |
| 18-Sep-08 | LIMONGELLI JOHN M Officer | N/A | Direct | Statement of Ownership | N/A |
| 12-Aug-08 | NICKELSON DONALD E Director | 67,306 | Direct | Purchase at $3.49 per share. | $234,897 |
| 11-Aug-08 | NICKELSON DONALD E Director | 32,694 | Direct | Purchase at $3.46 per share. | $113,121 |
| 23-May-08 | MADDEN DAVID Director | 64,400 | Indirect | Acquisition (Non Open Market) at $5.05 - $5.15 per share. | $328,0002 |
| 22-May-08 | NASH CLAUDE Director | 1,419 | Direct | Acquisition (Non Open Market) at $0 per share. | N/A |
| 22-May-08 | NICKELSON DONALD E Director | 946 | Direct | Acquisition (Non Open Market) at $0 per share. | N/A |
| 22-May-08 | GEMAYEL GEORGES Director | 946 | Direct | Acquisition (Non Open Market) at $0 per share. | N/A |
| 22-May-08 | ANIDO ARMANDO Director | 1,419 | Direct | Acquisition (Non Open Market) at $0 per share. | N/A |
| 22-May-08 | HAGER GEORGE V JR Director | 1,703 | Direct | Acquisition (Non Open Market) at $0 per share. | N/A |
| 22-May-08 | GODDARD PAUL Director | 946 | Direct | Acquisition (Non Open Market) at $0 per share. | N/A |
| 22-May-08 | MADDEN DAVID Director | 3,502 | Direct | Acquisition (Non Open Market) at $0 per share. | N/A |
| 20-May-08 | HESS THOMAS P Officer | 7,000 | Direct | Option Exercise at $0 per share. | N/A |
| 20-May-08 | HESS THOMAS P Officer | 2,753 | Direct | Disposition (Non Open Market) at $5.23 per share. | $14,398 |
| 20-May-08 | HESS THOMAS P Officer | 2,000 | Direct | Acquisition (Non Open Market) at $0 per share. | N/A |
| 20-May-08 | MANNING MARTHA E Officer | 11,500 | Direct | Option Exercise at $0 per share. | N/A |
| 20-May-08 | MANNING MARTHA E Officer | 4,610 | Direct | Disposition (Non Open Market) at $5.23 per share. | $24,110 |
| 20-May-08 | MANNING MARTHA E Officer | 3,575 | Direct | Acquisition (Non Open Market) at $0 per share. | N/A |
| 20-May-08 | JACKSON DAVID Officer | 5,000 | Direct | Option Exercise at $0 per share. | N/A |
| 20-May-08 | JACKSON DAVID Officer | 2,645 | Direct | Disposition (Non Open Market) at $5.23 per share. | $13,833 |
| 20-May-08 | JACKSON DAVID Officer | 5,000 | Direct | Acquisition (Non Open Market) at $0 per share. | N/A |
| 20-May-08 | DOUGHERTY MICHAEL R Officer | 21,500 | Direct | Option Exercise at $0 per share. | N/A |
| 20-May-08 | DOUGHERTY MICHAEL R Officer | 27,189 | Direct | Disposition (Non Open Market) at $5.23 per share. | $142,198 |
| 20-May-08 | DOUGHERTY MICHAEL R Officer | 8,000 | Direct | Acquisition (Non Open Market) at $0 per share. | N/A |