| INSIDER TRANSACTIONS REPORTED - LAST TWO YEARS |
| Date | Insider | Shares | Type | Transaction | Value* | | 30-Sep-09 | CAGNONI PABLO J Officer | 61,373 | Direct | Disposition (Non Open Market) at $0 per share. | N/A | | 10-Aug-09 | BERNS PAUL L Officer | 342,000 | Direct | Option Exercise at $3.14 per share. | $1,073,880 | | 10-Aug-09 | BERNS PAUL L Officer | 342,000 | Direct | Automatic Sale at $8.24 per share. | $2,818,080 | | 10-Aug-09 | CARUSO JAMES V Officer | 85,400 | Direct | Option Exercise at $3.13 per share. | $267,302 | | 10-Aug-09 | CARUSO JAMES V Officer | 85,400 | Direct | Automatic Sale at $8.13 per share. | $694,302 | | 5-Aug-09 | BERNS PAUL L Officer | 8,000 | Direct | Option Exercise at $3.14 per share. | $25,120 | | 5-Aug-09 | BERNS PAUL L Officer | 8,000 | Direct | Automatic Sale at $8.14 per share. | $65,120 | | 5-Aug-09 | CARUSO JAMES V Officer | 14,600 | Direct | Option Exercise at $3.13 per share. | $45,698 | | 5-Aug-09 | CARUSO JAMES V Officer | 14,600 | Direct | Automatic Sale at $8.13 per share. | $118,698 | | 3-Aug-09 | GRABOYES MARC H Officer | 50,000 | Direct | Option Exercise at $2 - $2.7 per share. | N/A | | 3-Aug-09 | GRABOYES MARC H Officer | 50,000 | Direct | Automatic Sale at $8 per share. | $400,000 | | 3-Aug-09 | CARUSO JAMES V Officer | 50,000 | Direct | Option Exercise at $3.13 per share. | $156,500 | | 3-Aug-09 | CARUSO JAMES V Officer | 50,000 | Direct | Automatic Sale at $7.79 per share. | $389,500 | | 30-Jun-09 | BENNETT BRUCE K JR Officer | 226 | Direct | Purchase at $5.16 per share. | $1,166 | | 16-Jun-09 | CARUSO JAMES V Officer | 13,500 | Direct | Automatic Sale at $8.16 per share. | $110,160 | | 15-Jun-09 | CARUSO JAMES V Officer | 14,000 | Direct | Automatic Sale at $8.13 per share. | $113,820 | | 26-Mar-09 | CARUSO JAMES V Officer | 39,500 | Direct | Option Exercise at $3.13 per share. | $123,635 | | 26-Mar-09 | CARUSO JAMES V Officer | 39,500 | Direct | Automatic Sale at $7.37 per share. | $291,115 | | 25-Mar-09 | CARUSO JAMES V Officer | 6,900 | Direct | Option Exercise at $3.13 per share. | $21,597 | | 25-Mar-09 | CARUSO JAMES V Officer | 6,900 | Direct | Automatic Sale at $7.13 per share. | $49,197 | | 20-Mar-09 | CAGNONI PABLO J Officer | 6,200 | Direct | Automatic Sale at $6.63 per share. | $41,106 | | 16-Mar-09 | CARUSO JAMES V Officer | 3,600 | Direct | Option Exercise at $3.13 per share. | $11,268 | | 16-Mar-09 | CARUSO JAMES V Officer | 3,600 | Direct | Automatic Sale at $7.13 per share. | $25,668 | | 13-Mar-09 | GRABOYES MARC H Officer | 5,864 | Direct | Option Exercise at $2 per share. | $11,728 | | 13-Mar-09 | GRABOYES MARC H Officer | 5,864 | Direct | Automatic Sale at $7 per share. | $41,048 | | 13-Mar-09 | CLARK DAVID C Officer | 5,027 | Direct | Option Exercise at $2.93 per share. | $14,729 | | 13-Mar-09 | CLARK DAVID C Officer | 5,027 | Direct | Automatic Sale at $7 per share. | $35,189 | | 12-Mar-09 | GRABOYES MARC H Officer | 69,136 | Direct | Option Exercise at $2 per share. | $138,272 | | 12-Mar-09 | GRABOYES MARC H Officer | 69,136 | Direct | Automatic Sale at $7.02 per share. | $485,334 | | 12-Mar-09 | CLARK DAVID C Officer | 64,973 | Direct | Option Exercise at $2.28 - $2.93 per share. | N/A | | 12-Mar-09 | CLARK DAVID C Officer | 64,973 | Direct | Automatic Sale at $7.02 per share. | $456,110 | | 12-Mar-09 | CARUSO JAMES V Officer | 50,000 | Direct | Option Exercise at $3.13 per share. | $156,500 | | 12-Mar-09 | CARUSO JAMES V Officer | 50,000 | Direct | Automatic Sale at $7.13 per share. | $356,500 | | 10-Mar-09 | BERNS PAUL L Officer | 34,235 | Direct | Automatic Sale at $6.54 per share. | $223,896 | | 23-Feb-09 | GRABOYES MARC H Officer | 15,060 | Direct | Acquisition (Non Open Market) at $0 per share. | N/A | | 23-Feb-09 | CLARK DAVID C Officer | 5,875 | Direct | Acquisition (Non Open Market) at $0 per share. | N/A | | 23-Feb-09 | BENNETT BRUCE K JR Officer | 5,875 | Direct | Acquisition (Non Open Market) at $0 per share. | N/A | | 23-Feb-09 | BERNS PAUL L Officer | 46,667 | Direct | Acquisition (Non Open Market) at $0 per share. | N/A | | 23-Feb-09 | CARUSO JAMES V Officer | 23,873 | Direct | Acquisition (Non Open Market) at $0 per share. | N/A | | 23-Feb-09 | CAGNONI PABLO J Officer | 23,873 | Direct | Acquisition (Non Open Market) at $0 per share. | N/A | | 6-Feb-09 | 14159 CAPITAL (GP), LLC Beneficial Owner (10% or more) | 24,879 | Indirect | Sale at $8.17 - $8.26 per share. | $204,0002 | | 6-Feb-09 | BAKER BROTHERS LIFE SCIENCES CAPITAL (GP), LLC Beneficial Owner (10% or more) | 752,204 | Indirect | Sale at $8.17 - $8.26 per share. | $6,179,0002 | | 6-Feb-09 | BAKER / TISCH CAPITAL (GP), LLC Beneficial Owner (10% or more) | 9,388 | Indirect | Sale at $8.17 - $8.26 per share. | $77,0002 | | 6-Feb-09 | BAKER BROS. CAPITAL (GP), LLC Beneficial Owner (10% or more) | 212 | Indirect | Sale at $8.17 per share. | $1,732 | | 6-Feb-09 | BAKER BIOTECH CAPITAL (GP), LLC Beneficial Owner (10% or more) | 263,547 | Indirect | Sale at $8.17 - $8.26 per share. | $2,165,0002 | | 6-Feb-09 | BAKER JULIAN Beneficial Owner (10% or more) | 706 | Indirect | Sale at $8.17 - $8.26 per share. | $5,7992 | | 5-Feb-09 | 14159 CAPITAL (GP), LLC Beneficial Owner (10% or more) | 12,317 | Indirect | Sale at $8.11 - $8.17 per share. | $100,0002 | | 5-Feb-09 | BAKER BROTHERS LIFE SCIENCES CAPITAL (GP), LLC Beneficial Owner (10% or more) | 372,365 | Indirect | Sale at $8.11 - $8.17 per share. | $3,031,0002 | | 5-Feb-09 | BAKER / TISCH CAPITAL (GP), LLC Beneficial Owner (10% or more) | 4,646 | Indirect | Sale at $8.11 - $8.17 per share. | $38,0002 | | 5-Feb-09 | BAKER BROS. CAPITAL (GP), LLC Beneficial Owner (10% or more) | 105 | Indirect | Sale at $8.11 - $8.17 per share. | $8542 | | 5-Feb-09 | BAKER BIOTECH CAPITAL (GP), LLC Beneficial Owner (10% or more) | 130,463 | Indirect | Sale at $8.11 - $8.17 per share. | $1,062,0002 | | 5-Feb-09 | BAKER JULIAN Beneficial Owner (10% or more) | 349 | Indirect | Sale at $8.11 - $8.17 per share. | $2,8402 | | 4-Feb-09 | 14159 CAPITAL (GP), LLC Beneficial Owner (10% or more) | 36,586 | Indirect | Sale at $8.01 - $9.03 per share. | $312,0002 | | 4-Feb-09 | BAKER BROTHERS LIFE SCIENCES CAPITAL (GP), LLC Beneficial Owner (10% or more) | 1,106,246 | Indirect | Sale at $8.01 - $9.03 per share. | $9,425,0002 | | 4-Feb-09 | BAKER / TISCH CAPITAL (GP), LLC Beneficial Owner (10% or more) | 13,809 | Indirect | Sale at $8.01 - $9.03 per share. | $118,0002 | | 4-Feb-09 | BAKER BROS. CAPITAL (GP), LLC Beneficial Owner (10% or more) | 312 | Indirect | Sale at $8.01 - $9.03 per share. | $2,6582 | | 4-Feb-09 | BAKER BIOTECH CAPITAL (GP), LLC Beneficial Owner (10% or more) | 387,589 | Indirect | Sale at $8.01 - $9.03 per share. | $3,302,0002 | | 4-Feb-09 | HOFFMAN STEPHEN J Director | 36,400 | Direct | Option Exercise at $2.42 per share. | $88,088 | | 4-Feb-09 | HOFFMAN STEPHEN J Director | 36,400 | Direct | Automatic Sale at $9.03 per share. | $328,692 | | 4-Feb-09 | BAKER JULIAN Beneficial Owner (10% or more) | 1,039 | Indirect | Sale at $8.01 - $9.03 per share. | $8,8522 | | 23-Jan-09 | BAKER BROS. CAPITAL (GP), LLC Beneficial Owner (10% or more) | 75,118 | Indirect | Disposition (Non Open Market) at $0 per share. | N/A | | 23-Jan-09 | BAKER BROS. CAPITAL (GP), LLC Beneficial Owner (10% or more) | 75,118 | Indirect | Disposition (Non Open Market) at $0 per share. | N/A | | 31-Dec-08 | BENNETT BRUCE K JR Officer | 221 | Direct | Purchase at $5.20 per share. | $1,149 | | 2-Sep-08 | HOFFMAN STEPHEN J Director | 40,000 | Direct | Option Exercise at $2.42 per share. | $96,800 | | 2-Sep-08 | HOFFMAN STEPHEN J Director | 40,000 | Direct | Automatic Sale at $9.68 per share. | $387,200 | | 2-Sep-08 | CARUSO JAMES V Officer | 10,000 | Direct | Automatic Sale at $9.68 per share. | $96,800 | | 29-May-08 | HEN STEWART Director | 3,500,000 | Indirect | Purchase at $5.64 per share. | $19,740,000 | | 29-May-08 | LEFF JONATHAN S Director | 3,500,000 | Indirect | Purchase at $5.64 per share. | $19,740,000 | | 29-May-08 | BAKER BROS. CAPITAL (GP), LLC Beneficial Owner (10% or more) | 4,610 | Indirect | Disposition (Non Open Market) at $0 per share. | N/A | | 29-May-08 | WARBURG PINCUS PRIVATE EQUITY VIII L P Director | 3,500,000 | Direct | Purchase at $5.64 per share. | $19,740,000 | | 28-May-08 | BAKER BROS. CAPITAL (GP), LLC Beneficial Owner (10% or more) | 109,834 | Indirect | Disposition (Non Open Market) at $0 per share. | N/A | | 22-May-08 | 14159 CAPITAL (GP), LLC Beneficial Owner (10% or more) | 36,784 | Indirect | Purchase at $5.64 per share. | $207,461 | | 22-May-08 | BAKER BROTHERS LIFE SCIENCES CAPITAL (GP), LLC Beneficial Owner (10% or more) | 1,146,462 | Indirect | Purchase at $5.64 per share. | $6,466,045 | | 22-May-08 | BAKER BIOTECH CAPITAL (GP), LLC Beneficial Owner (10% or more) | 316,754 | Indirect | Purchase at $5.64 per share. | $1,786,492 | | 20-Mar-08 | CAGNONI PABLO J Officer | 6,100 | Direct | Automatic Sale at $5.28 - $5.3 per share. | $32,0002 | | 10-Mar-08 | BERNS PAUL L Officer | 34,400 | Direct | Automatic Sale at $5.19 - $5.52 per share. | $184,0002 | | 25-Feb-08 | 14159 CAPITAL (GP), LLC Beneficial Owner (10% or more) | 2,699 | Indirect | Purchase at $6 per share. | $16,194 | | 25-Feb-08 | BAKER BROTHERS LIFE SCIENCES CAPITAL (GP), LLC Beneficial Owner (10% or more) | 85,055 | Indirect | Purchase at $6 per share. | $510,330 | | 25-Feb-08 | BAKER / TISCH CAPITAL (GP), LLC Beneficial Owner (10% or more) | 425 | Indirect | Purchase at $6 per share. | $2,550 | | 25-Feb-08 | BAKER BROS. CAPITAL (GP), LLC Beneficial Owner (10% or more) | 91 | Indirect | Purchase at $6 per share. | $546 | | 25-Feb-08 | BAKER BIOTECH CAPITAL (GP), LLC Beneficial Owner (10% or more) | 11,730 | Indirect | Purchase at $6 per share. | $70,380 | | 21-Feb-08 | 14159 CAPITAL (GP), LLC Beneficial Owner (10% or more) | 3,913 | Indirect | Purchase at $5.90 - $6.2 per share. | $24,0002 | | 21-Feb-08 | BAKER BROTHERS LIFE SCIENCES CAPITAL (GP), LLC Beneficial Owner (10% or more) | 123,330 | Indirect | Purchase at $5.90 - $6.2 per share. | $746,0002 | | 21-Feb-08 | BAKER / TISCH CAPITAL (GP), LLC Beneficial Owner (10% or more) | 617 | Indirect | Purchase at $5.90 - $6.2 per share. | $3,7322 | | 21-Feb-08 | BAKER BROS. CAPITAL (GP), LLC Beneficial Owner (10% or more) | 132 | Indirect | Purchase at $5.90 - $6.2 per share. | $7982 | | 21-Feb-08 | BAKER BIOTECH CAPITAL (GP), LLC Beneficial Owner (10% or more) | 17,008 | Indirect | Purchase at $5.90 - $6.2 per share. | $103,0002 | | 20-Feb-08 | 14159 CAPITAL (GP), LLC Beneficial Owner (10% or more) | 2,058 | Indirect | Purchase at $6.50 per share. | $13,377 | | 20-Feb-08 | BAKER BROTHERS LIFE SCIENCES CAPITAL (GP), LLC Beneficial Owner (10% or more) | 64,825 | Indirect | Purchase at $6.50 per share. | $421,362 | | 20-Feb-08 | BAKER / TISCH CAPITAL (GP), LLC Beneficial Owner (10% or more) | 453 | Indirect | Purchase at $6.50 per share. | $2,944 | | 20-Feb-08 | BAKER BROS. CAPITAL (GP), LLC Beneficial Owner (10% or more) | 104 | Indirect | Purchase at $6.50 per share. | $676 | | 20-Feb-08 | BAKER BIOTECH CAPITAL (GP), LLC Beneficial Owner (10% or more) | 8,940 | Indirect | Purchase at $6.50 per share. | $58,110 | | 19-Feb-08 | 14159 CAPITAL (GP), LLC Beneficial Owner (10% or more) | 2,039 | Indirect | Purchase at $6.75 per share. | $13,763 | | 19-Feb-08 | BAKER BROTHERS LIFE SCIENCES CAPITAL (GP), LLC Beneficial Owner (10% or more) | 64,259 | Indirect | Purchase at $6.75 per share. | $433,748 | | 19-Feb-08 | BAKER / TISCH CAPITAL (GP), LLC Beneficial Owner (10% or more) | 450 | Indirect | Purchase at $6.75 per share. | $3,037 | | 19-Feb-08 | BAKER BROS. CAPITAL (GP), LLC Beneficial Owner (10% or more) | 103 | Indirect | Purchase at $6.75 per share. | $695 | | 19-Feb-08 | BAKER BIOTECH CAPITAL (GP), LLC Beneficial Owner (10% or more) | 8,862 | Indirect | Purchase at $6.75 per share. | $59,818 | | 23-Jan-08 | 14159 CAPITAL (GP), LLC Beneficial Owner (10% or more) | 624 | Indirect | Purchase at $6.95 per share. | $4,336 | | 23-Jan-08 | BAKER BROTHERS LIFE SCIENCES CAPITAL (GP), LLC Beneficial Owner (10% or more) | 19,608 | Indirect | Purchase at $6.95 per share. | $136,275 | | 23-Jan-08 | BAKER / TISCH CAPITAL (GP), LLC Beneficial Owner (10% or more) | 392 | Indirect | Purchase at $6.95 per share. | $2,724 | | 23-Jan-08 | BAKER BROS. CAPITAL (GP), LLC Beneficial Owner (10% or more) | 53 | Indirect | Purchase at $6.95 per share. | $368 | | 22-Jan-08 | 14159 CAPITAL (GP), LLC Beneficial Owner (10% or more) | 19 | Indirect | Purchase at $6.92 per share. | $131 | | 22-Jan-08 | BAKER BROTHERS LIFE SCIENCES CAPITAL (GP), LLC Beneficial Owner (10% or more) | 555 | Indirect | Purchase at $6.92 per share. | $3,840 | | 22-Jan-08 | BAKER / TISCH CAPITAL (GP), LLC Beneficial Owner (10% or more) | 11 | Indirect | Purchase at $6.92 per share. | $76 | | 22-Jan-08 | BAKER BROS. CAPITAL (GP), LLC Beneficial Owner (10% or more) | 1 | Indirect | Purchase at $6.92 per share. | $6 | | 22-Jan-08 | BAKER BIOTECH CAPITAL (GP), LLC Beneficial Owner (10% or more) | 161 | Indirect | Purchase at $6.92 per share. | $1,114 | | 18-Jan-08 | 14159 CAPITAL (GP), LLC Beneficial Owner (10% or more) | 297 | Indirect | Purchase at $7.15 - $7.22 per share. | $2,1332 | | 18-Jan-08 | BAKER BROTHERS LIFE SCIENCES CAPITAL (GP), LLC Beneficial Owner (10% or more) | 9,238 | Indirect | Purchase at $7.15 - $7.22 per share. | $66,0002 | | 18-Jan-08 | BAKER / TISCH CAPITAL (GP), LLC Beneficial Owner (10% or more) | 190 | Indirect | Purchase at $7.15 - $7.22 per share. | $1,3652 | | 18-Jan-08 | BAKER BROS. CAPITAL (GP), LLC Beneficial Owner (10% or more) | 23 | Indirect | Purchase at $7.15 - $7.22 per share. | $1652 | | 18-Jan-08 | BAKER BIOTECH CAPITAL (GP), LLC Beneficial Owner (10% or more) | 2,676 | Indirect | Purchase at $7.15 - $7.22 per share. | $19,0002 | | 15-Jan-08 | 14159 CAPITAL (GP), LLC Beneficial Owner (10% or more) | 620 | Indirect | Purchase at $7.50 per share. | $4,650 | | 15-Jan-08 | BAKER BROTHERS LIFE SCIENCES CAPITAL (GP), LLC Beneficial Owner (10% or more) | 19,334 | Indirect | Purchase at $7.50 per share. | $145,005 | | 15-Jan-08 | BAKER / TISCH CAPITAL (GP), LLC Beneficial Owner (10% or more) | 399 | Indirect | Purchase at $7.50 per share. | $2,992 | | 15-Jan-08 | BAKER BROS. CAPITAL (GP), LLC Beneficial Owner (10% or more) | 47 | Indirect | Purchase at $7.50 per share. | $352 | | 15-Jan-08 | BAKER BIOTECH CAPITAL (GP), LLC Beneficial Owner (10% or more) | 5,600 | Indirect | Purchase at $7.50 per share. | $42,000 | | 14-Jan-08 | 14159 CAPITAL (GP), LLC Beneficial Owner (10% or more) | 2,847 | Indirect | Purchase at $7.41 per share. | $21,096 | | 14-Jan-08 | BAKER BROTHERS LIFE SCIENCES CAPITAL (GP), LLC Beneficial Owner (10% or more) | 89,632 | Indirect | Purchase at $7.41 per share. | $664,173 | | 14-Jan-08 | BAKER / TISCH CAPITAL (GP), LLC Beneficial Owner (10% or more) | 1,871 | Indirect | Purchase at $7.41 per share. | $13,864 | | 14-Jan-08 | BAKER BROS. CAPITAL (GP), LLC Beneficial Owner (10% or more) | 245 | Indirect | Purchase at $7.41 per share. | $1,815 | | 14-Jan-08 | BAKER BIOTECH CAPITAL (GP), LLC Beneficial Owner (10% or more) | 35,405 | Indirect | Purchase at $7.41 per share. | $262,351 | | 11-Jan-08 | 14159 CAPITAL (GP), LLC Beneficial Owner (10% or more) | 1,205 | Indirect | Purchase at $7.47 per share. | $9,001 | | 11-Jan-08 | BAKER BROTHERS LIFE SCIENCES CAPITAL (GP), LLC Beneficial Owner (10% or more) | 37,921 | Indirect | Purchase at $7.47 per share. | $283,269 | | 11-Jan-08 | BAKER / TISCH CAPITAL (GP), LLC Beneficial Owner (10% or more) | 792 | Indirect | Purchase at $7.47 per share. | $5,916 | | 11-Jan-08 | BAKER BROS. CAPITAL (GP), LLC Beneficial Owner (10% or more) | 103 | Indirect | Purchase at $7.47 per share. | $769 | | 11-Jan-08 | BAKER BIOTECH CAPITAL (GP), LLC Beneficial Owner (10% or more) | 14,979 | Indirect | Purchase at $7.47 per share. | $111,893 | | 10-Jan-08 | 14159 CAPITAL (GP), LLC Beneficial Owner (10% or more) | 2,536 | Indirect | Purchase at $7.47 per share. | $18,943 | | 10-Jan-08 | BAKER BROTHERS LIFE SCIENCES CAPITAL (GP), LLC Beneficial Owner (10% or more) | 79,841 | Indirect | Purchase at $7.47 per share. | $596,412 | | 10-Jan-08 | BAKER / TISCH CAPITAL (GP), LLC Beneficial Owner (10% or more) | 1,667 | Indirect | Purchase at $7.47 per share. | $12,452 | | 10-Jan-08 | BAKER BROS. CAPITAL (GP), LLC Beneficial Owner (10% or more) | 218 | Indirect | Purchase at $7.47 per share. | $1,628 | | 10-Jan-08 | BAKER BIOTECH CAPITAL (GP), LLC Beneficial Owner (10% or more) | 31,538 | Indirect | Purchase at $7.47 per share. | $235,588 | | 9-Jan-08 | 14159 CAPITAL (GP), LLC Beneficial Owner (10% or more) | 1,368 | Indirect | Purchase at $6.96 per share. | $9,521 | | 9-Jan-08 | BAKER BROTHERS LIFE SCIENCES CAPITAL (GP), LLC Beneficial Owner (10% or more) | 43,023 | Indirect | Purchase at $6.96 per share. | $299,440 | | 9-Jan-08 | BAKER / TISCH CAPITAL (GP), LLC Beneficial Owner (10% or more) | 898 | Indirect | Purchase at $6.96 per share. | $6,250 | | 9-Jan-08 | BAKER BROS. CAPITAL (GP), LLC Beneficial Owner (10% or more) | 117 | Indirect | Purchase at $6.96 per share. | $814 | | 9-Jan-08 | BAKER BIOTECH CAPITAL (GP), LLC Beneficial Owner (10% or more) | 16,994 | Indirect | Purchase at $6.96 per share. | $118,278 | | 8-Jan-08 | 14159 CAPITAL (GP), LLC Beneficial Owner (10% or more) | 4,380 | Indirect | Purchase at $7.21 per share. | $31,579 | | 8-Jan-08 | BAKER BROTHERS LIFE SCIENCES CAPITAL (GP), LLC Beneficial Owner (10% or more) | 137,895 | Indirect | Purchase at $7.21 per share. | $994,222 | | 8-Jan-08 | BAKER / TISCH CAPITAL (GP), LLC Beneficial Owner (10% or more) | 2,879 | Indirect | Purchase at $7.21 per share. | $20,757 | | 8-Jan-08 | BAKER BROS. CAPITAL (GP), LLC Beneficial Owner (10% or more) | 376 | Indirect | Purchase at $7.21 per share. | $2,710 | | 8-Jan-08 | BAKER BIOTECH CAPITAL (GP), LLC Beneficial Owner (10% or more) | 54,470 | Indirect | Purchase at $7.21 per share. | $392,728 | | 7-Jan-08 | 14159 CAPITAL (GP), LLC Beneficial Owner (10% or more) | 2,223 | Indirect | Purchase at $6.37 - $6.85 per share. | $15,0002 | | 7-Jan-08 | BAKER BROTHERS LIFE SCIENCES CAPITAL (GP), LLC Beneficial Owner (10% or more) | 69,943 | Indirect | Purchase at $6.37 - $6.85 per share. | $462,0002 | | 7-Jan-08 | BAKER / TISCH CAPITAL (GP), LLC Beneficial Owner (10% or more) | 1,460 | Indirect | Purchase at $6.37 - $6.85 per share. | $9,6502 | | 7-Jan-08 | BAKER BROS. CAPITAL (GP), LLC Beneficial Owner (10% or more) | 190 | Indirect | Purchase at $6.37 - $6.85 per share. | $1,2552 | | 7-Jan-08 | BAKER BIOTECH CAPITAL (GP), LLC Beneficial Owner (10% or more) | 27,628 | Indirect | Purchase at $6.37 - $6.85 per share. | $183,0002 | | 7-Jan-08 | JOHNSON DOUGLAS G Officer | 1,500 | Direct | Option Exercise at $2.42 per share. | $3,630 | | 7-Jan-08 | JOHNSON DOUGLAS G Officer | 1,500 | Direct | Automatic Sale at $7.24 per share. | $10,860 | | 2-Jan-08 | JOHNSON DOUGLAS G Officer | 1,500 | Direct | Option Exercise at $2.42 per share. | $3,630 | | 2-Jan-08 | JOHNSON DOUGLAS G Officer | 1,500 | Direct | Automatic Sale at $6.29 per share. | $9,435 | | 31-Dec-07 | BERNS PAUL L Officer | 5,000 | Direct | Purchase at $3.89 per share. | $19,450 | | 31-Dec-07 | JOHNSON DOUGLAS G Officer | 547 | Direct | Purchase at $3.89 per share. | $2,127 | | 3-Dec-07 | JOHNSON DOUGLAS G Officer | 1,500 | Direct | Option Exercise at $2.42 - $2.42 per share. | $3,6302 | | 3-Dec-07 | JOHNSON DOUGLAS G Officer | 1,500 | Direct | Automatic Sale at $7.26 per share. | $10,890 | | 28-Nov-07 | JOHNSON DOUGLAS G Officer | 1,500 | Direct | Option Exercise at $2.42 - $2.42 per share. | $3,6302 | | 28-Nov-07 | JOHNSON DOUGLAS G Officer | 1,500 | Direct | Automatic Sale at $6.72 - $6.72 per share. | $10,0002 |
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* = Where indicated, some values are estimates. 1 = Potential proceeds estimated by the filer. 2 = Estimated based on the average of multiple prices reported. 3 = Multiple dates reported. Most recent date shown. |
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