| INSIDER TRANSACTIONS REPORTED - LAST TWO YEARS |
| Date | Insider | Shares | Type | Transaction | Value* | | 13-Nov-09 | ADAGE CAPITAL PARTNERS GP LLC Beneficial Owner (10% or more) | 96,900 | Indirect | Purchase at $43 per share. | $4,166,700 | | 12-Nov-09 | ADAGE CAPITAL PARTNERS GP LLC Beneficial Owner (10% or more) | 3,100 | Indirect | Purchase at $42.97 per share. | $133,207 | | 12-Nov-09 | ARKOWITZ DAVID Officer | 4,459 | Direct | Sale at $43.42 per share. | $193,609 | | 10-Nov-09 | PEREIRA BRIAN JG Officer | 83,000 | Direct | Option Exercise at $10.80 - $13.55 per share. | N/A | | 10-Nov-09 | PEREIRA BRIAN JG Officer | 83,000 | Direct | Sale at $43.15 - $43.39 per share. | $3,591,0002 | | 10-Nov-09 | ADAGE CAPITAL PARTNERS GP LLC Beneficial Owner (10% or more) | 577,324 | Indirect | Option Exercise at $24.75 per share. | $14,288,769 | | 10-Nov-09 | ADAGE CAPITAL PARTNERS GP LLC Beneficial Owner (10% or more) | 477,324 | Indirect | Acquisition (Non Open Market) at $42.72 per share. | $20,391,281 | | 10-Nov-09 | ADAGE CAPITAL PARTNERS GP LLC Beneficial Owner (10% or more) | 100,000 | Indirect | Disposition (Non Open Market) at $42.72 per share. | $4,272,000 | | 9-Nov-09 | PEREIRA BRIAN JG Officer | 114,044 | Direct | Option Exercise at $8.98 - $9.1 per share. | $1,031,0002 | | 9-Nov-09 | PEREIRA BRIAN JG Officer | 114,044 | Direct | Sale at $43.35 - $44.25 per share. | $4,995,0002 | | 9-Nov-09 | PEREIRA BRIAN JG Officer | 32,967 | Indirect | Sale at $44.82 per share. | $1,477,580 | | 9-Nov-09 | ADAGE CAPITAL PARTNERS GP LLC Beneficial Owner (10% or more) | 136,000 | Indirect | Purchase at $43.81 per share. | $5,958,160 | | 6-Nov-09 | ADAGE CAPITAL PARTNERS GP LLC Beneficial Owner (10% or more) | 100,000 | Indirect | Purchase at $44.61 per share. | $4,461,000 | | 5-Nov-09 | ADAGE CAPITAL PARTNERS GP LLC Beneficial Owner (10% or more) | 153,088 | Indirect | Purchase at $42.47 per share. | $6,501,647 | | 3-Nov-09 | ADAGE CAPITAL PARTNERS GP LLC Beneficial Owner (10% or more) | 92,000 | Indirect | Purchase at $41.60 per share. | $3,827,200 | | 6-Aug-09 | ALLEN LEE F MD PHD Officer | 1,250 | Direct | Acquisition (Non Open Market) | N/A | | 5-Aug-09 | PEREIRA BRIAN JG Officer | 5,000 | Direct | Sale at $45 - $45.01 per share. | $225,0002 | | 3-Aug-09 | ARKOWITZ DAVID Officer | 750 | Direct | Acquisition (Non Open Market) | N/A | | 3-Aug-09 | HEALEY TIMOTHY G Officer | 399 | Direct | Sale at $45.48 per share. | $18,146 | | 3-Aug-09 | PEREIRA BRIAN JG Officer | 5,000 | Direct | Acquisition (Non Open Market) | N/A | | 8-Jun-09 | ZAYAS RICARDO Officer | 7,587 | Direct | Statement of Ownership | N/A | | 2-Jun-09 | ALLEN LEE F MD PHD Officer | 626 | Direct | Purchase at $25.61 per share. | $16,031 | | 2-Jun-09 | ARKOWITZ DAVID Officer | 529 | Direct | Purchase at $25.61 per share. | $13,547 | | 12-Mar-09 | ADAGE CAPITAL PARTNERS GP LLC Beneficial Owner (10% or more) | 11,028 | Indirect | Purchase at $25.32 per share. | $279,228 | | 11-Mar-09 | ADAGE CAPITAL PARTNERS GP LLC Beneficial Owner (10% or more) | 24,751 | Indirect | Purchase at $25.58 per share. | $633,130 | | 9-Mar-09 | ADAGE CAPITAL PARTNERS GP LLC Beneficial Owner (10% or more) | 59,858 | Indirect | Purchase at $25.34 per share. | $1,516,801 | | 5-Mar-09 | ADAGE CAPITAL PARTNERS GP LLC Beneficial Owner (10% or more) | 577,324 | Indirect | Option Exercise at $34.84 - $45.21 per share. | N/A | | 5-Mar-09 | ADAGE CAPITAL PARTNERS GP LLC Beneficial Owner (10% or more) | 577,324 | Indirect | Disposition (Non Open Market) at $24.75 per share. | $14,288,769 | | 4-Mar-09 | ADAGE CAPITAL PARTNERS GP LLC Beneficial Owner (10% or more) | 133,061 | Indirect | Purchase at $26.64 per share. | $3,544,745 | | 3-Mar-09 | ADAGE CAPITAL PARTNERS GP LLC Beneficial Owner (10% or more) | 1,914,123 | Indirect | Statement of Ownership | N/A | | 31-Dec-08 | ALLEN LEE F MD PHD Officer | 1,250 | Direct | Option Exercise | N/A | | 1-Dec-08 | ALLEN LEE F MD PHD Officer | 544 | Direct | Acquisition (Non Open Market) at $28.63 per share. | $15,574 | | 1-Dec-08 | HEALEY TIMOTHY G Officer | 750 | Direct | Option Exercise | N/A | | 1-Dec-08 | HEALEY TIMOTHY G Officer | 1,020 | Direct | Automatic Sale at $32.86 per share. | $33,517 | | 31-Jul-08 | LEWIS JEROME M Officer | 997 | Direct | Automatic Sale at $40 per share. | $39,880 | | 11-Jun-08 | ARKOWITZ DAVID Officer | 1,000 | Direct | Purchase at $37.50 per share. | $37,500 | | 9-Jun-08 | ZWANZIGER RON Director | 2,500 | Indirect | Acquisition (Non Open Market) at $38.95 per share. | $97,375 | | 2-Jun-08 | HEALEY TIMOTHY G Officer | 399 | Direct | Acquisition (Non Open Market) at $34 per share. | $13,566 | | 2-Jun-08 | ARKOWITZ DAVID Officer | 430 | Direct | Acquisition (Non Open Market) at $34 per share. | $14,620 | | 22-Feb-08 | LEWIS JEROME M Officer | 11,125 | Direct | Automatic Sale at $46.13 per share. | $513,196 | | 20-Feb-08 | LEWIS JEROME M Officer | 5,000 | Direct | Automatic Sale at $50.52 per share. | $252,600 | | 13-Feb-08 | LEWIS JEROME M Officer | 1,000 | Direct | Automatic Sale at $54.33 per share. | $54,330 | | 8-Feb-08 | PEREIRA BRIAN JG Officer | 5,000 | Direct | Automatic Sale at $54.66 per share. | $273,300 | | 7-Feb-08 | PEREIRA BRIAN JG Officer | 5,000 | Direct | Option Exercise at $0 per share. | N/A | | 7-Feb-08 | LEWIS JEROME M Officer | 17,125 | Direct | Option Exercise at $0 - $19.98 per share. | N/A | | 7-Feb-08 | LEWIS JEROME M Officer | 1,750 | Direct | Automatic Sale at $52.99 per share. | $92,732 | | 18-Jan-08 | LEWIS JEROME M Officer | 17,202 | Direct | Automatic Sale at $62.50 per share. | $1,075,125 | | 6-Dec-07 | BRENNER LOUIS MD Officer | 500 | Direct | Option Exercise at $35.29 - $35.29 per share. | $18,0002 | | 6-Dec-07 | BRENNER LOUIS MD Officer | 500 | Direct | Automatic Sale at $60 - $60 per share. | $30,0002 | | 5-Dec-07 | HEALEY TIMOTHY G Officer | 750 | Direct | Sale at $59.12 per share. | $44,340 | | 3-Dec-07 | BRENNER LOUIS MD Officer | 255 | Direct | Acquisition (Non Open Market) at $48.99 - $48.99 per share. | $12,0002 | | 3-Dec-07 | HEALEY TIMOTHY G Officer | 270 | Direct | Acquisition (Non Open Market) at $48.99 - $48.99 per share. | $13,0002 | | 3-Dec-07 | ARKOWITZ DAVID Officer | 306 | Direct | Acquisition (Non Open Market) at $48.99 per share. | $14,990 | | 1-Dec-07 | HEALEY TIMOTHY G Officer | 750 | Direct | Option Exercise | N/A |
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* = Where indicated, some values are estimates. 1 = Potential proceeds estimated by the filer. 2 = Estimated based on the average of multiple prices reported. 3 = Multiple dates reported. Most recent date shown. |
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