| Date | Insider | Shares | Type | Transaction | Value* |
| 23-Nov-09 | BARABE TIMOTHY C Director | 514 | Direct | Acquisition (Non Open Market) at $3.49 per share. | $1,793 |
| 23-Nov-09 | LOBERG MICHAEL D Director | 286 | Direct | Acquisition (Non Open Market) at $3.49 per share. | $998 |
| 19-Nov-09 | LOBERG MICHAEL D Director | 155 | Direct | Acquisition (Non Open Market) at $3.21 per share. | $497 |
| 18-Nov-09 | BARABE TIMOTHY C Director | 1,209 | Direct | Acquisition (Non Open Market) at $3.41 per share. | $4,122 |
| 18-Nov-09 | LOBERG MICHAEL D Director | 549 | Direct | Acquisition (Non Open Market) at $3.41 per share. | $1,872 |
| 12-Nov-09 | PUCCI PAOLO Officer | 5,000 | Direct | Purchase at $3.48 per share. | $17,400 |
| 28-Oct-09 | BARABE TIMOTHY C Director | 174 | Direct | Acquisition (Non Open Market) at $3.44 per share. | $598 |
| 26-Oct-09 | LOBERG MICHAEL D Director | 141 | Direct | Acquisition (Non Open Market) at $3.54 per share. | $499 |
| 8-Oct-09 | LOBERG MICHAEL D Director | 119 | Direct | Acquisition (Non Open Market) at $4.20 per share. | $499 |
| 23-Sep-09 | BARABE TIMOTHY C Director | 479 | Direct | Acquisition (Non Open Market) at $5.01 per share. | $2,399 |
| 23-Sep-09 | LOBERG MICHAEL D Director | 399 | Direct | Acquisition (Non Open Market) at $5.01 per share. | $1,998 |
| 17-Sep-09 | BVF PARTNERS L P/IL Beneficial Owner (10% or more) | 3,680,000 | Direct | Sale at $5.25 per share. | $19,320,000 |
| 28-Aug-09 | LOBERG MICHAEL D Director | 180 | Direct | Acquisition (Non Open Market) at $5.54 per share. | $997 |
| 21-Aug-09 | LOBERG MICHAEL D Director | 83 | Direct | Acquisition (Non Open Market) at $5.98 per share. | $496 |
| 18-Aug-09 | LOBERG MICHAEL D Director | 356 | Direct | Purchase at $5.26 per share. | $1,872 |
| 18-Aug-09 | BARABE TIMOTHY C Director | 784 | Direct | Purchase at $5.26 per share. | $4,123 |
| 13-Aug-09 | LOBERG MICHAEL D Director | 88 | Direct | Purchase at $5.65 per share. | $497 |
| 5-Aug-09 | BARABE TIMOTHY C Director | 104 | Direct | Purchase at $5.73 per share. | $595 |
| 24-Jul-09 | BARABE TIMOTHY C Director | 206 | Direct | Purchase at $5.82 per share. | $1,198 |
| 24-Jul-09 | LOBERG MICHAEL D Director | 171 | Direct | Purchase at $5.82 per share. | $995 |
| 9-Jun-09 | PUCCI PAOLO Officer | 19,875 | Direct | Disposition (Non Open Market) at $5.47 per share. | $108,716 |
| 18-May-09 | LOBERG MICHAEL D Director | 456 | Direct | Purchase at $4.11 per share. | $1,874 |
| 18-May-09 | BARABE TIMOTHY C Director | 1,003 | Direct | Purchase at $4.11 per share. | $4,122 |
| 14-May-09 | BARABE TIMOTHY C Director | 310 | Direct | Purchase at $3.87 per share. | $1,199 |
| 14-May-09 | LOBERG MICHAEL D Director | 258 | Direct | Purchase at $3.87 per share. | $998 |
| 13-May-09 | PUCCI PAOLO Officer | 2,500 | Direct | Purchase at $3.85 per share. | $9,625 |
| 29-Apr-09 | BARABE TIMOTHY C Director | 133 | Direct | Purchase at $4.50 per share. | $598 |
| 9-Apr-09 | LOBERG MICHAEL D Director | 105 | Direct | Purchase at $4.75 per share. | $498 |
| 12-Mar-09 | BARABE TIMOTHY C Director | 338 | Direct | Purchase at $3.55 per share. | $1,199 |
| 12-Mar-09 | LOBERG MICHAEL D Director | 281 | Direct | Purchase at $3.55 per share. | $997 |
| 4-Mar-09 | BARABE TIMOTHY C Director | 206 | Direct | Purchase at $2.90 per share. | $597 |
| 18-Feb-09 | LOBERG MICHAEL D Director | 474 | Direct | Purchase at $3.95 per share. | $1,872 |
| 18-Feb-09 | BARABE TIMOTHY C Director | 1,044 | Direct | Purchase at $3.95 per share. | $4,123 |
| 12-Feb-09 | LOBERG MICHAEL D Director | 114 | Direct | Purchase at $4.35 per share. | $495 |
| 20-Jan-09 | LOBERG MICHAEL D Director | 282 | Direct | Purchase at $3.54 per share. | $998 |
| 20-Jan-09 | BARABE TIMOTHY C Director | 338 | Direct | Purchase at $3.54 per share. | $1,196 |
| 20-Jan-09 | PUCCI PAOLO Officer | 67,500 | Direct | Acquisition (Non Open Market) | N/A |
| 20-Jan-09 | WEISKOPF ROBERT J Officer | 12,000 | Direct | Acquisition (Non Open Market) | N/A |
| 20-Jan-09 | SCHWARTZ BRIAN Officer | 11,700 | Direct | Acquisition (Non Open Market) | N/A |
| 20-Jan-09 | LAWRENCE PETER S Officer | 75,000 | Direct | Acquisition (Non Open Market) | N/A |
| 20-Jan-09 | CHAN THOMAS C K Officer | 20,000 | Direct | Acquisition (Non Open Market) | N/A |
| 17-Jan-09 | WEISKOPF ROBERT J Officer | 356 | Direct | Disposition (Non Open Market) at $3.93 per share. | $1,399 |
| 16-Dec-08 | LOBERG MICHAEL D Director | 128 | Direct | Purchase at $3.88 per share. | $496 |
| 5-Dec-08 | SCHWARTZ BRIAN Officer | 10,000 | Direct | Purchase at $3.39 per share. | $33,900 |
| 24-Nov-08 | LOBERG MICHAEL D Director | 162 | Direct | Purchase at $3.08 per share. | $498 |
| 21-Nov-08 | ZENNER PATRICK J Director | 20,000 | Direct | Purchase at $2.43 per share. | $48,600 |
| 21-Nov-08 | BVF PARTNERS L P/IL Beneficial Owner (10% or more) | 340,900 | Indirect | Purchase at $2.40 per share. | $818,160 |
| 19-Nov-08 | BVF PARTNERS L P/IL Beneficial Owner (10% or more) | 294,413 | Indirect | Purchase at $2.65 per share. | $780,194 |
| 17-Nov-08 | BARABE TIMOTHY C Director | 2,041 | Direct | Purchase at $2.90 per share. | $5,918 |
| 17-Nov-08 | LOBERG MICHAEL D Director | 39,480 | Direct | Purchase at $2.90 - $3 per share. | $116,0002 |
| 14-Nov-08 | LOBERG MICHAEL D Director | 1,800 | Direct | Purchase at $2.84 per share. | $5,112 |
| 13-Nov-08 | PUCCI PAOLO Officer | 18,250 | Direct | Purchase at $2.68 per share. | $48,910 |
| 13-Nov-08 | LAWRENCE PETER S Officer | 10,000 | Direct | Purchase at $2.66 per share. | $26,600 |
| 13-Nov-08 | LINDSAY RONALD M Director | 20,000 | Direct | Purchase at $2.50 - $2.6 per share. | $51,0002 |
| 13-Nov-08 | LOBERG MICHAEL D Director | 9,710 | Direct | Purchase at $2.87 per share. | $27,867 |
| 12-Nov-08 | BVF PARTNERS L P/IL Beneficial Owner (10% or more) | 377,000 | Indirect | Purchase at $2.45 per share. | $923,650 |
| 11-Nov-08 | BVF PARTNERS L P/IL Beneficial Owner (10% or more) | 412,200 | Indirect | Purchase at $2.25 per share. | $927,450 |
| 10-Nov-08 | BVF PARTNERS L P/IL Beneficial Owner (10% or more) | 1,338,500 | Indirect | Purchase at $2.35 per share. | $3,145,475 |
| 29-Oct-08 | BARABE TIMOTHY C Director | 242 | Direct | Purchase at $2.47 per share. | $597 |
| 27-Oct-08 | LOBERG MICHAEL D Director | 526 | Direct | Purchase at $1.90 per share. | $999 |
| 27-Oct-08 | BARABE TIMOTHY C Director | 631 | Direct | Purchase at $1.90 per share. | $1,198 |
| 9-Oct-08 | LOBERG MICHAEL D Director | 222 | Direct | Purchase at $2.25 per share. | $499 |
| 12-Sep-08 | BARABE TIMOTHY C Director | 695 | Direct | Purchase at $3.45 per share. | $2,397 |
| 12-Sep-08 | LOBERG MICHAEL D Director | 579 | Direct | Purchase at $3.45 per share. | $1,997 |
| 28-Aug-08 | BARABE TIMOTHY C Director | 216 | Direct | Acquisition (Non Open Market) at $5.54 per share. | $1,196 |
| 19-Aug-08 | PUCCI PAOLO Officer | 37,706 | Direct | Acquisition (Non Open Market) at $3.62 per share. | $136,495 |
| 18-Aug-08 | BARABE TIMOTHY C Director | 1,152 | Direct | Purchase at $3.58 per share. | $4,124 |
| 18-Aug-08 | LOBERG MICHAEL D Director | 523 | Direct | Purchase at $3.58 per share. | $1,872 |
| 7-Aug-08 | LOBERG MICHAEL D Director | 143 | Direct | Purchase at $3.49 per share. | $499 |
| 30-Jul-08 | BARABE TIMOTHY C Director | 157 | Direct | Purchase at $3.81 per share. | $598 |
| 17-Jul-08 | BARABE TIMOTHY C Director | 301 | Direct | Purchase at $3.98 per share. | $1,197 |
| 17-Jul-08 | LOBERG MICHAEL D Director | 251 | Direct | Purchase at $3.98 per share. | $998 |
| 11-Jul-08 | LOBERG MICHAEL D Director | 132 | Direct | Purchase at $3.78 per share. | $498 |
| 17-Jun-08 | BARABE TIMOTHY C Director | 294 | Direct | Purchase at $4.07 per share. | $1,196 |
| 9-Jun-08 | PUCCI PAOLO Officer | 125,000 | Direct | Acquisition (Non Open Market) | N/A |
| 9-Jun-08 | PUCCI PAOLO Officer | 23,750 | Direct | Disposition (Non Open Market) at $3.95 per share. | $93,812 |
| 5-Jun-08 | LOBERG MICHAEL D Director | 114 | Direct | Purchase at $4.35 per share. | $495 |
| 29-May-08 | BARABE TIMOTHY C Director | 1,003 | Direct | Purchase at $4.11 per share. | $4,122 |
| 29-May-08 | LOBERG MICHAEL D Director | 456 | Direct | Purchase at $4.11 per share. | $1,874 |
| 15-May-08 | BARABE TIMOTHY C Director | 292 | Direct | Purchase at $4.10 per share. | $1,197 |
| 15-May-08 | LOBERG MICHAEL D Director | 243 | Direct | Purchase at $4.10 per share. | $996 |
| 7-May-08 | LOBERG MICHAEL D Director | 134 | Direct | Purchase at $3.72 per share. | $498 |
| 30-Apr-08 | BARABE TIMOTHY C Director | 155 | Direct | Purchase at $3.85 per share. | $596 |
| 10-Apr-08 | LOBERG MICHAEL D Director | 128 | Direct | Purchase at $3.88 per share. | $496 |
| 25-Mar-08 | BARABE TIMOTHY C Director | 289 | Direct | Purchase at $4.15 per share. | $1,199 |
| 25-Mar-08 | LOBERG MICHAEL D Director | 240 | Direct | Purchase at $4.15 per share. | $996 |
| 21-Mar-08 | LOBERG MICHAEL D Director | 123 | Direct | Purchase at $4.04 per share. | $496 |
| 10-Mar-08 | BVF PARTNERS L P/IL Beneficial Owner (10% or more) | 1,363,283 | Indirect | Purchase at $3.90 per share. | $5,316,803 |
| 5-Mar-08 | BARABE TIMOTHY C Director | 135 | Direct | Purchase at $4.43 per share. | $598 |
| 26-Feb-08 | BARABE TIMOTHY C Director | 120 | Direct | Purchase at $4.99 per share. | $598 |
| 22-Feb-08 | BVF PARTNERS L P/IL Beneficial Owner (10% or more) | 8,200 | Indirect | Purchase at $4.75 per share. | $38,950 |
| 21-Feb-08 | BVF PARTNERS L P/IL Beneficial Owner (10% or more) | 186,000 | Indirect | Purchase at $4.95 per share. | $920,700 |
| 20-Feb-08 | BVF PARTNERS L P/IL Beneficial Owner (10% or more) | 28,100 | Indirect | Purchase at $5.05 per share. | $141,905 |
| 19-Feb-08 | BVF PARTNERS L P/IL Beneficial Owner (10% or more) | 32,300 | Indirect | Purchase at $5.10 per share. | $164,730 |
| 15-Feb-08 | BVF PARTNERS L P/IL Beneficial Owner (10% or more) | 49,600 | Indirect | Purchase at $5.08 per share. | $251,968 |
| 15-Feb-08 | BARABE TIMOTHY C Director | 797 | Direct | Purchase at $5.17 per share. | $4,120 |
| 15-Feb-08 | LOBERG MICHAEL D Director | 362 | Direct | Purchase at $5.17 per share. | $1,871 |
| 14-Feb-08 | LOBERG MICHAEL D Director | 95 | Direct | Purchase at $5.24 per share. | $497 |
| 11-Feb-08 | BVF PARTNERS L P/IL Beneficial Owner (10% or more) | 83,700 | Indirect | Purchase at $4.96 per share. | $415,152 |
| 8-Feb-08 | BVF PARTNERS L P/IL Beneficial Owner (10% or more) | 259,000 | Indirect | Purchase at $4.98 per share. | $1,289,820 |
| 7-Feb-08 | BVF PARTNERS L P/IL Beneficial Owner (10% or more) | 368,300 | Indirect | Purchase at $4.90 per share. | $1,804,670 |
| 6-Feb-08 | BARABE TIMOTHY C Director | 114 | Direct | Purchase at $5.22 per share. | $595 |
| 4-Feb-08 | BVF PARTNERS L P/IL Beneficial Owner (10% or more) | 210,100 | Indirect | Purchase at $5.08 per share. | $1,067,308 |
| 1-Feb-08 | BVF PARTNERS L P/IL Beneficial Owner (10% or more) | 165,000 | Indirect | Purchase at $5 per share. | $825,000 |
| 31-Jan-08 | BVF PARTNERS L P/IL Beneficial Owner (10% or more) | 510,000 | Indirect | Purchase at $4.71 per share. | $2,402,100 |
| 23-Jan-08 | BVF PARTNERS L P/IL Beneficial Owner (10% or more) | 154,600 | Indirect | Purchase at $4.47 per share. | $691,062 |
| 17-Jan-08 | BARABE TIMOTHY C Director | 252 | Direct | Purchase at $4.75 per share. | $1,197 |
| 17-Jan-08 | LOBERG MICHAEL D Director | 210 | Direct | Purchase at $4.75 per share. | $997 |
| 17-Jan-08 | WEISKOPF ROBERT J Officer | 2,500 | Direct | Acquisition (Non Open Market) | N/A |
| 15-Jan-08 | BVF PARTNERS L P/IL Beneficial Owner (10% or more) | 107,300 | Indirect | Purchase at $4.65 per share. | $498,945 |
| 14-Jan-08 | BVF PARTNERS L P/IL Beneficial Owner (10% or more) | 24,800 | Indirect | Purchase at $4.50 per share. | $111,600 |
| 10-Jan-08 | BVF PARTNERS L P/IL Beneficial Owner (10% or more) | 324,227 | Indirect | Purchase at $4.26 - $4.37 per share. | $1,399,0002 |
| 9-Jan-08 | BVF PARTNERS L P/IL Beneficial Owner (10% or more) | 122,700 | Indirect | Purchase at $4.29 per share. | $526,383 |
| 8-Jan-08 | BVF PARTNERS L P/IL Beneficial Owner (10% or more) | 5,930,777 | Indirect | Statement of Ownership | N/A |
| 8-Jan-08 | BVF PARTNERS L P/IL Beneficial Owner (10% or more) | 3,469,800 | Direct | Statement of Ownership | N/A |
| 3-Jan-08 | LOBERG MICHAEL D Director | 86 | Direct | Purchase at $5.78 per share. | $497 |
| 20-Dec-07 | BARABE TIMOTHY C Director | 201 | Direct | Purchase at $5.95 per share. | $1,195 |
| 20-Dec-07 | LOBERG MICHAEL D Director | 252 | Direct | Purchase at $5.95 per share. | $1,499 |
| 14-Dec-07 | BARABE TIMOTHY C Director | 2,000 | Direct | Disposition (Non Open Market) at $6.05 per share. | $12,100 |