| INSIDER TRANSACTIONS REPORTED - LAST TWO YEARS |
| Date | Insider | Shares | Type | Transaction | Value* | | 17-Mar-09 | SHEFFERY MICHAEL B Director | 110,000 | Indirect | Purchase at $0.84 per share. | $92,400 | | 17-Mar-09 | ORBIMED ADVISORS LLC Director | 110,000 | Indirect | Purchase at $0.84 per share. | $92,400 | | 16-Mar-09 | SHEFFERY MICHAEL B Director | 52,200 | Indirect | Purchase at $0.65 per share. | $33,930 | | 16-Mar-09 | ORBIMED ADVISORS LLC Director | 52,200 | Indirect | Purchase at $0.65 per share. | $33,930 | | 16-Mar-09 | VAN BOKKELEN GIL Officer | 10,000 | Direct | Purchase at $0.67 per share. | $6,700 | | 16-Dec-08 | VAN BOKKELEN GIL Officer | 5,000 | Direct | Purchase at $0.50 per share. | $2,500 | | 16-Dec-08 | LEHMANN WILLIAM JR Officer | 900 | Direct | Purchase at $0.42 per share. | $378 | | 3-Dec-08 | VAN BOKKELEN GIL Officer | 12,500 | Direct | Purchase at $0.35 per share. | $4,375 | | 2-Dec-08 | VAN BOKKELEN GIL Officer | 12,500 | Direct | Purchase at $0.35 per share. | $4,375 | | 28-Nov-08 | VAN BOKKELEN GIL Officer | 22,500 | Direct | Purchase at $0.40 - $0.49 per share. | N/A | | 24-Nov-08 | VAN BOKKELEN GIL Officer | 12,500 | Direct | Purchase at $0.33 per share. | $4,125 | | 24-Nov-08 | HARRINGTON JOHN J Officer | 5,000 | Direct | Purchase at $0.33 per share. | $1,650 | | 21-Nov-08 | HARRINGTON JOHN J Officer | 5,835 | Direct | Purchase at $0.33 per share. | $1,925 | | 22-May-08 | SHEFFERY MICHAEL B Director | 268,000 | Indirect | Purchase at $2.40 per share. | $643,200 | | 22-May-08 | ORBIMED ADVISORS LLC Director | 268,000 | Indirect | Purchase at $2.40 per share. | $643,200 | | 21-May-08 | SHEFFERY MICHAEL B Director | 130,000 | Indirect | Purchase at $2.40 per share. | $312,000 | | 21-May-08 | ORBIMED ADVISORS LLC Director | 130,000 | Indirect | Purchase at $2.40 per share. | $312,000 | | 13-May-08 | SHEFFERY MICHAEL B Director | 50,000 | Indirect | Purchase at $2.40 per share. | $120,000 | | 13-May-08 | ORBIMED ADVISORS LLC Director | 50,000 | Indirect | Purchase at $2.40 per share. | $120,000 | | 12-Dec-07 | VAN BOKKELEN GIL Officer | 3,000 | Direct | Purchase at $5 per share. | $15,000 | | 5-Dec-07 | LEHMANN WILLIAM JR Officer | 1,000 | Direct | Purchase at $4.55 per share. | $4,550 |
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* = Where indicated, some values are estimates. 1 = Potential proceeds estimated by the filer. 2 = Estimated based on the average of multiple prices reported. 3 = Multiple dates reported. Most recent date shown. |
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