| INSIDER TRANSACTIONS REPORTED - LAST TWO YEARS |
| Date | Insider | Shares | Type | Transaction | Value* | | 19-Nov-09 | HOROVITZ ZOLA P Director | 5,000 | Direct | Sale at $1.43 per share. | $7,150 | | 18-Nov-09 | BVF PARTNERS L P/IL Beneficial Owner (10% or more) | 626 | Direct | Sale at $1.50 per share. | $939 | | 29-Oct-09 | BURLINGAME ASSET MANAGEMENT, LLC Beneficial Owner (10% or more) | 2,000 | Direct | Purchase at $1.47 per share. | $2,940 | | 28-Oct-09 | BURLINGAME ASSET MANAGEMENT, LLC Beneficial Owner (10% or more) | 6,435 | Direct | Purchase at $1.48 per share. | $9,523 | | 21-Oct-09 | BVF PARTNERS L P/IL Beneficial Owner (10% or more) | 472,200 | Direct | Sale at $1.50 per share. | $708,300 | | 21-Oct-09 | SOUTHPAW CREDIT OPPORTUNITY MASTER FUND, L.P. Beneficial Owner (10% or more) | 482,390 | Indirect | Purchase at $1.50 - $1.53 per share. | $731,0002 | | 20-Oct-09 | SOUTHPAW CREDIT OPPORTUNITY MASTER FUND, L.P. Beneficial Owner (10% or more) | 20,989 | Indirect | Purchase at $1.53 per share. | $32,113 | | 19-Oct-09 | SOUTHPAW CREDIT OPPORTUNITY MASTER FUND, L.P. Beneficial Owner (10% or more) | 38,039 | Indirect | Purchase at $1.51 per share. | $57,438 | | 14-Oct-09 | SOUTHPAW CREDIT OPPORTUNITY MASTER FUND, L.P. Beneficial Owner (10% or more) | 14,888 | Indirect | Purchase at $1.51 - $1.52 per share. | $23,0002 | | 13-Oct-09 | SOUTHPAW CREDIT OPPORTUNITY MASTER FUND, L.P. Beneficial Owner (10% or more) | 9,150 | Indirect | Purchase at $1.51 per share. | $13,816 | | 9-Oct-09 | SOUTHPAW CREDIT OPPORTUNITY MASTER FUND, L.P. Beneficial Owner (10% or more) | 882,221 | Indirect | Purchase at $1.53 per share. | $1,349,798 | | 5-Oct-09 | SOUTHPAW CREDIT OPPORTUNITY MASTER FUND, L.P. Beneficial Owner (10% or more) | 9,057 | Indirect | Purchase at $1.51 per share. | $13,676 | | 2-Oct-09 | SOUTHPAW CREDIT OPPORTUNITY MASTER FUND, L.P. Beneficial Owner (10% or more) | 19,299 | Indirect | Purchase at $1.52 per share. | $29,334 | | 1-Oct-09 | SOUTHPAW CREDIT OPPORTUNITY MASTER FUND, L.P. Beneficial Owner (10% or more) | 22,131 | Indirect | Purchase at $1.51 per share. | $33,417 | | 1-Oct-09 | SOUTHPAW CREDIT OPPORTUNITY MASTER FUND, L.P. Beneficial Owner (10% or more) | 3,386,344 | Indirect | Statement of Ownership | N/A | | 17-Sep-09 | BURLINGAME ASSET MANAGEMENT, LLC Beneficial Owner (10% or more) | 632 | Direct | Purchase at $1.45 per share. | $916 | | 14-Sep-09 | BURLINGAME ASSET MANAGEMENT, LLC Beneficial Owner (10% or more) | 682,698 | Direct | Purchase at $1.54 per share. | $1,051,354 | | 11-Sep-09 | BURLINGAME ASSET MANAGEMENT, LLC Beneficial Owner (10% or more) | 43,670 | Direct | Purchase at $1.51 per share. | $65,941 | | 10-Sep-09 | BURLINGAME ASSET MANAGEMENT, LLC Beneficial Owner (10% or more) | 2,254,724 | Direct | Statement of Ownership | N/A | | 23-Jan-09 | BVF ACQUISITION LLC Other | N/A | Direct | Statement of Ownership | N/A | | 9-Jan-09 | PERRY MATTHEW D Other | N/A | Direct | Statement of Ownership | N/A | | 9-Jan-09 | NODELMAN OLEG Other | N/A | Direct | Statement of Ownership | N/A | | 9-Jan-09 | COPPEDGE ROBERT M Other | N/A | Direct | Statement of Ownership | N/A | | 9-Jan-09 | LAMPERT MARK N Beneficial Owner (10% or more) | 4,969,764 | Indirect | Statement of Ownership | N/A | | 19-Nov-08 | BVF PARTNERS L P/IL Beneficial Owner (10% or more) | 30,300 | Indirect | Purchase at $0.75 per share. | $22,725 | | 18-Nov-08 | BVF PARTNERS L P/IL Beneficial Owner (10% or more) | 128,000 | Indirect | Purchase at $0.74 per share. | $94,720 | | 13-Nov-08 | BVF PARTNERS L P/IL Beneficial Owner (10% or more) | 26,500 | Indirect | Purchase at $0.75 per share. | $19,875 | | 12-Nov-08 | BVF PARTNERS L P/IL Beneficial Owner (10% or more) | 82,000 | Indirect | Purchase at $0.75 per share. | $61,500 | | 12-Nov-08 | BVF PARTNERS L P/IL Beneficial Owner (10% or more) | 82,000 | Indirect | Purchase at $0.75 per share. | $61,500 | | 11-Nov-08 | BVF PARTNERS L P/IL Beneficial Owner (10% or more) | 75,200 | Indirect | Purchase at $0.74 per share. | $55,648 | | 11-Nov-08 | BVF PARTNERS L P/IL Beneficial Owner (10% or more) | 75,200 | Indirect | Purchase at $0.74 per share. | $55,648 | | 10-Nov-08 | BVF PARTNERS L P/IL Beneficial Owner (10% or more) | 145,400 | Indirect | Purchase at $0.73 per share. | $106,142 | | 10-Nov-08 | BVF PARTNERS L P/IL Beneficial Owner (10% or more) | 145,400 | Indirect | Purchase at $0.73 per share. | $106,142 | | 7-Nov-08 | BVF PARTNERS L P/IL Beneficial Owner (10% or more) | 40,400 | Indirect | Purchase at $0.72 per share. | $29,088 | | 6-Nov-08 | BVF PARTNERS L P/IL Beneficial Owner (10% or more) | 87,100 | Indirect | Purchase at $0.71 per share. | $61,841 | | 4-Nov-08 | BVF PARTNERS L P/IL Beneficial Owner (10% or more) | 53,300 | Indirect | Purchase at $0.74 per share. | $39,442 | | 21-Oct-08 | BVF PARTNERS L P/IL Beneficial Owner (10% or more) | 7,729,115 | Indirect | Statement of Ownership | N/A | | 21-Oct-08 | BVF PARTNERS L P/IL Beneficial Owner (10% or more) | 4,622,764 | Direct | Statement of Ownership | N/A | | 14-Aug-08 | PRENDERGAST JOHN K A Director | 337 | Direct | Sale at $3.47 per share. | $1,169 | | 13-Aug-08 | PRENDERGAST JOHN K A Director | 7,163 | Direct | Sale at $3.38 - $3.43 per share. | $24,0002 | | 5-May-08 | IWAKI YUICHI Director | 5,643 | Indirect | Sale at $3.16 - $3.38 per share. | $18,0002 |
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* = Where indicated, some values are estimates. 1 = Potential proceeds estimated by the filer. 2 = Estimated based on the average of multiple prices reported. 3 = Multiple dates reported. Most recent date shown. |
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