| Date | Insider | Shares | Type | Transaction | Value* |
| 17-Nov-09 | LYNCH SAMUEL EUGENE Officer | 3,000 | Direct | Sale at $11.64 per share. | $34,920 |
| 16-Nov-09 | LYNCH SAMUEL EUGENE Officer | 3,000 | Direct | Sale at $11.80 per share. | $35,400 |
| 5-Nov-09 | LYNCH SAMUEL EUGENE Officer | 3,000 | Direct | Sale at $11.70 per share. | $35,100 |
| 4-Nov-09 | LYNCH SAMUEL EUGENE Officer | 3,000 | Direct | Sale at $11.63 per share. | $34,890 |
| 21-Oct-09 | LYNCH SAMUEL EUGENE Officer | 4,500 | Direct | Sale at $13.85 per share. | $62,325 |
| 20-Oct-09 | LYNCH SAMUEL EUGENE Officer | 4,500 | Direct | Sale at $14.21 - $14.22 per share. | $64,0002 |
| 6-Oct-09 | LYNCH SAMUEL EUGENE Officer | 4,500 | Direct | Sale at $12.56 - $12.57 per share. | $57,0002 |
| 5-Oct-09 | LYNCH SAMUEL EUGENE Officer | 3,000 | Direct | Sale at $11.50 per share. | $34,500 |
| 24-Sep-09 | LYNCH SAMUEL EUGENE Officer | 4,500 | Direct | Automatic Sale at $12.98 - $12.99 per share. | $58,0002 |
| 23-Sep-09 | LYNCH SAMUEL EUGENE Officer | 4,500 | Direct | Automatic Sale at $13.05 - $13.12 per share. | $59,0002 |
| 10-Sep-09 | LYNCH SAMUEL EUGENE Officer | 3,000 | Direct | Automatic Sale at $11.99 per share. | $35,970 |
| 9-Sep-09 | LYNCH SAMUEL EUGENE Officer | 3,000 | Direct | Automatic Sale at $12.01 per share. | $36,030 |
| 26-Aug-09 | LYNCH SAMUEL EUGENE Officer | 3,000 | Direct | Automatic Sale at $11.47 per share. | $34,410 |
| 25-Aug-09 | LYNCH SAMUEL EUGENE Officer | 3,000 | Direct | Automatic Sale at $11.72 per share. | $35,160 |
| 13-Aug-09 | LYNCH SAMUEL EUGENE Officer | 3,000 | Direct | Automatic Sale at $10.79 per share. | $32,369 |
| 12-Aug-09 | LYNCH SAMUEL EUGENE Officer | 3,000 | Direct | Automatic Sale at $10.85 per share. | $32,550 |
| 30-Jul-09 | LYNCH SAMUEL EUGENE Officer | 3,000 | Direct | Automatic Sale at $9.90 - $10.29 per share. | $30,0002 |
| 29-Jul-09 | LYNCH SAMUEL EUGENE Officer | 3,000 | Direct | Automatic Sale at $9.76 - $9.93 per share. | $30,0002 |
| 28-Jul-09 | BULLOCK LAWRENCE E Officer | 4,000 | Indirect | Acquisition (Non Open Market) at $0 per share. | N/A |
| 28-Jul-09 | BULLOCK LAWRENCE E Officer | 4,000 | Direct | Disposition (Non Open Market) at $0 per share. | N/A |
| 17-Jul-09 | LYNCH SAMUEL EUGENE Officer | 3,000 | Direct | Automatic Sale at $9.59 - $9.95 per share. | $29,0002 |
| 16-Jul-09 | LYNCH SAMUEL EUGENE Officer | 3,000 | Direct | Automatic Sale at $9.74 - $10 per share. | $30,0002 |
| 1-Jul-09 | LYNCH SAMUEL EUGENE Officer | 3,000 | Direct | Automatic Sale at $9.25 - $9.48 per share. | $28,0002 |
| 30-Jun-09 | LYNCH SAMUEL EUGENE Officer | 3,000 | Direct | Automatic Sale at $9.16 - $9.5 per share. | $28,0002 |
| 26-Jun-09 | WATSON DOUGLAS G Director | 19,035 | Direct | Option Exercise at $3.47 - $3.63 per share. | $68,0002 |
| 25-Jun-09 | NOVO A/S Beneficial Owner (10% or more) | 343,406 | Direct | Purchase at $8.50 per share. | $2,918,951 |
| 25-Jun-09 | FRIEDLAENDER GARY E Director | 7,230 | Indirect | Purchase at $8.50 per share. | $61,455 |
| 25-Jun-09 | FRIEDLAENDER GARY E Director | 944 | Direct | Purchase at $8.50 per share. | $8,024 |
| 25-Jun-09 | MURPHY JAMES G Director | 508 | Direct | Purchase at $8.50 per share. | $4,318 |
| 18-Jun-09 | CHRISTENSEN THORKIL K. Director | 2,507 | Direct | Statement of Ownership | N/A |
| 17-Jun-09 | LYNCH SAMUEL EUGENE Officer | 3,000 | Direct | Automatic Sale at $9 - $9.05 per share. | $27,0002 |
| 16-Jun-09 | LYNCH SAMUEL EUGENE Officer | 3,000 | Direct | Automatic Sale at $9 per share. | $27,000 |
| 4-Jun-09 | LYNCH SAMUEL EUGENE Officer | 3,000 | Direct | Automatic Sale at $9 - $9.12 per share. | $27,0002 |
| 3-Jun-09 | LYNCH SAMUEL EUGENE Officer | 3,000 | Direct | Automatic Sale at $9 - $9.07 per share. | $27,0002 |
| 7-Apr-09 | EHRLICH CHRISTOPHER B Director | 941,177 | Indirect | Purchase at $8.50 per share. | $8,000,004 |
| 1-Apr-09 | BULLOCK LAWRENCE E Officer | 6,000 | Direct | Purchase at $6.72 - $6.87 per share. | $41,0002 |
| 17-Mar-09 | DOUGLAS EARL MARTIN Officer | 1,200 | Direct | Sale at $8.45 per share. | $10,140 |
| 29-Jan-09 | NOVO A/S Beneficial Owner (10% or more) | 50,000 | Direct | Purchase at $9.63 per share. | $481,500 |
| 29-Jan-09 | LYNCH SAMUEL EUGENE Officer | 50,000 | Direct | Sale at $9.63 per share. | $481,500 |
| 2-Jan-09 | FRIEDLAENDER GARY E Director | 1,000 | Indirect | Acquisition (Non Open Market) at $0 per share. | N/A |
| 2-Jan-09 | FRIEDLAENDER GARY E Director | 1,000 | Direct | Disposition (Non Open Market) at $0 per share. | N/A |
| 10-Dec-08 | FRIEDLAENDER GARY E Director | 6,500 | Indirect | Acquisition (Non Open Market) at $0 per share. | N/A |
| 10-Dec-08 | FRIEDLAENDER GARY E Director | 6,500 | Direct | Disposition (Non Open Market) at $0 per share. | N/A |
| 11-Nov-08 | NOVO A/S Beneficial Owner (10% or more) | 500 | Direct | Purchase at $8 per share. | $4,000 |
| 27-Oct-08 | FRIEDLAENDER GARY E Director | 7,500 | Direct | Option Exercise at $0.67 per share. | $5,025 |
| 27-Oct-08 | LYNCH SAMUEL EUGENE Officer | 77,250 | Direct | Option Exercise at $3.47 - $3.63 per share. | $274,0002 |
| 9-Sep-08 | NOVO A/S Beneficial Owner (10% or more) | 172 | Direct | Purchase at $10.47 per share. | $1,800 |
| 8-Sep-08 | NOVO A/S Beneficial Owner (10% or more) | 600 | Direct | Purchase at $10.63 - $10.66 per share. | $6,3872 |
| 8-Sep-08 | NOVO A/S Beneficial Owner (10% or more) | 19,400 | Direct | Purchase at $10.26 - $10.6 per share. | $202,0002 |
| 5-Sep-08 | NOVO A/S Beneficial Owner (10% or more) | 24,700 | Direct | Purchase at $10.20 - $10.5 per share. | $256,0002 |
| 4-Sep-08 | NOVO A/S Beneficial Owner (10% or more) | 6,100 | Direct | Purchase at $10.55 - $11 per share. | $66,0002 |
| 4-Sep-08 | NOVO A/S Beneficial Owner (10% or more) | 71,807 | Direct | Purchase at $10.32 - $10.54 per share. | $749,0002 |
| 4-Sep-08 | NOVO A/S Beneficial Owner (10% or more) | 500 | Direct | Purchase at $10.30 - $10.31 per share. | $5,1522 |
| 3-Sep-08 | NOVO A/S Beneficial Owner (10% or more) | 18,100 | Direct | Purchase at $10.57 - $11 per share. | $195,0002 |
| 2-Sep-08 | NOVO A/S Beneficial Owner (10% or more) | 7,052 | Direct | Purchase at $10.75 - $11 per share. | $77,0002 |
| 2-Sep-08 | NOVO A/S Beneficial Owner (10% or more) | 2,948 | Direct | Purchase at $10.62 - $10.74 per share. | $31,0002 |
| 29-Aug-08 | NOVO A/S Beneficial Owner (10% or more) | 10,202 | Direct | Purchase at $10.61 - $11 per share. | $110,0002 |
| 28-Aug-08 | NOVO A/S Beneficial Owner (10% or more) | 1,700 | Direct | Purchase at $10.80 - $11 per share. | $19,0002 |
| 27-Aug-08 | NOVO A/S Beneficial Owner (10% or more) | 7,300 | Direct | Purchase at $10.88 - $11 per share. | $80,0002 |
| 4-Aug-08 | HART CHARLES EDWARD Officer | 47,500 | Direct | Option Exercise at $2.87 per share. | $136,325 |
| 4-Aug-08 | HART CHARLES EDWARD Officer | 10,001 | Direct | Disposition (Non Open Market) at $13.63 per share. | $136,313 |
| 7-Jul-08 | NOVO A/S Beneficial Owner (10% or more) | 5,146 | Direct | Purchase at $11 per share. | $56,606 |
| 24-Jun-08 | NOVO A/S Beneficial Owner (10% or more) | 248,202 | Direct | Purchase at $11 per share. | $2,730,222 |
| 22-May-08 | NOVO A/S Beneficial Owner (10% or more) | 12,931 | Direct | Purchase at $10.87 - $11 per share. | $141,0002 |
| 13-May-08 | NOVO A/S Beneficial Owner (10% or more) | 7,843 | Direct | Purchase at $10.92 - $11 per share. | $86,0002 |
| 9-May-08 | NOVO A/S Beneficial Owner (10% or more) | 25,100 | Direct | Purchase at $10.71 - $11 per share. | $272,0002 |
| 8-May-08 | NOVO A/S Beneficial Owner (10% or more) | 6,843 | Direct | Purchase at $10.09 - $10.46 per share. | $70,0002 |
| 8-May-08 | NOVO A/S Beneficial Owner (10% or more) | 12,596 | Direct | Purchase at $10.29 - $10.59 per share. | $132,0002 |
| 8-May-08 | NOVO A/S Beneficial Owner (10% or more) | 11,300 | Direct | Purchase at $10.30 - $10.43 per share. | $117,0002 |
| 7-May-08 | NOVO A/S Beneficial Owner (10% or more) | 13,769 | Direct | Purchase at $10.11 - $10.4 per share. | $141,0002 |
| 7-May-08 | NOVO A/S Beneficial Owner (10% or more) | 7,792 | Direct | Purchase at $10.47 - $10.6 per share. | $82,0002 |
| 6-May-08 | NOVO A/S Beneficial Owner (10% or more) | 8,309 | Direct | Purchase at $10.44 - $10.61 per share. | $87,0002 |
| 6-May-08 | NOVO A/S Beneficial Owner (10% or more) | 15,191 | Direct | Purchase at $10.20 - $10.3 per share. | $156,0002 |
| 6-May-08 | NOVO A/S Beneficial Owner (10% or more) | 10,600 | Direct | Purchase at $1.17 - $10.2 per share. | N/A |
| 5-May-08 | NOVO A/S Beneficial Owner (10% or more) | 39,182 | Direct | Purchase at $10.50 - $10.75 per share. | $416,0002 |
| 2-May-08 | NOVO A/S Beneficial Owner (10% or more) | 700 | Direct | Purchase at $10.50 per share. | $7,350 |
| 1-May-08 | NOVO A/S Beneficial Owner (10% or more) | 28,118 | Direct | Purchase at $9.90 - $10.5 per share. | $287,0002 |
| 30-Apr-08 | NOVO A/S Beneficial Owner (10% or more) | 20,900 | Direct | Purchase at $9.65 - $10 per share. | $205,0002 |
| 29-Apr-08 | NOVO A/S Beneficial Owner (10% or more) | 253,693 | Direct | Purchase at $9.65 - $10.2 per share. | $2,518,0002 |
| 28-Apr-08 | NOVO A/S Beneficial Owner (10% or more) | 9,200 | Direct | Purchase at $10.11 - $10.15 per share. | $93,0002 |
| 28-Apr-08 | NOVO A/S Beneficial Owner (10% or more) | 35,000 | Direct | Purchase at $9.70 - $10.15 per share. | $347,0002 |
| 25-Apr-08 | NOVO A/S Beneficial Owner (10% or more) | 11,392 | Direct | Purchase at $9.94 - $10.28 per share. | $115,0002 |
| 14-Apr-08 | DOUGLAS EARL MARTIN Officer | 8,500 | Direct | Option Exercise at $3.63 per share. | $30,855 |
| 31-Mar-08 | HART CHARLES EDWARD Officer | 35,000 | Direct | Option Exercise at $2.87 per share. | $100,450 |
| 28-Mar-08 | FRIEDLAENDER GARY E Director | 8,500 | Direct | Purchase at $8.99 per share. | $76,415 |
| 28-Mar-08 | LYNCH SAMUEL EUGENE Officer | 5,400 | Direct | Purchase at $8.86 - $9 per share. | $48,0002 |
| 28-Mar-08 | DOUGLAS EARL MARTIN Officer | 1,000 | Direct | Purchase at $9.05 per share. | $9,050 |
| 28-Mar-08 | MURPHY JAMES G Director | 5,000 | Direct | Purchase at $8.40 per share. | $42,000 |
| 28-Mar-08 | FEDERICO CHARLES Director | 1,075 | Direct | Purchase at $9.24 - $9.25 per share. | $9,9382 |
| 28-Mar-08 | BULLOCK LAWRENCE E Officer | 10,000 | Direct | Purchase at $9 per share. | $90,000 |
| 27-Mar-08 | WATSON DOUGLAS G Director | 21,375 | Direct | Option Exercise at $2.87 - $3.47 per share. | $68,0002 |
| 5-Mar-08 | MONSOR JAMES A. Officer | 46,875 | Direct | Option Exercise at $2.87 - $3.47 per share. | $149,0002 |
| 27-Feb-08 | BULLOCK LAWRENCE E Officer | 2,000 | Direct | Disposition (Non Open Market) at $0 per share. | N/A |
| 27-Feb-08 | BULLOCK LAWRENCE E Officer | 2,000 | Indirect | Acquisition (Non Open Market) at $0 per share. | N/A |
| 23-Jan-08 | DOUGLAS EARL MARTIN Officer | 3,500 | Direct | Purchase at $15.19 - $15.3 per share. | $53,0002 |
| 31-Dec-07 | MONSOR JAMES A. Officer | 14,000 | Direct | Automatic Sale at $16.90 - $17.07 per share. | $238,0002 |
| 31-Dec-07 | BULLOCK LAWRENCE E Officer | 2,000 | Indirect | Acquisition (Non Open Market) at $0 per share. | N/A |
| 31-Dec-07 | BULLOCK LAWRENCE E Officer | 2,000 | Direct | Disposition (Non Open Market) at $0 per share. | N/A |