| INSIDER TRANSACTIONS REPORTED - LAST TWO YEARS |
| Date | Insider | Shares | Type | Transaction | Value* | | 9-Nov-09 | SOCKS DAVID A Officer | 12,500 | Direct | Automatic Sale at $10 per share. | $125,000 | | 5-Nov-09 | BREITMEYER JAMES B Officer | 1,000 | Direct | Option Exercise at $3.20 per share. | $3,200 | | 5-Nov-09 | BREITMEYER JAMES B Officer | 1,000 | Direct | Automatic Sale at $10 per share. | $10,000 | | 20-Oct-09 | CRAIG WILLIAM S Officer | 5,000 | Direct | Option Exercise at $0.40 per share. | $2,000 | | 20-Oct-09 | CRAIG WILLIAM S Officer | 5,000 | Direct | Automatic Sale at $10.47 per share. | $52,350 | | 16-Oct-09 | SCHROEDER THEODORE R Officer | 20,000 | Indirect | Automatic Sale at $10.72 per share. | $214,400 | | 12-Oct-09 | SOCKS DAVID A Officer | 12,500 | Direct | Automatic Sale at $11.60 per share. | $145,000 | | 1-Oct-09 | BREITMEYER JAMES B Officer | 1,000 | Direct | Option Exercise at $3.20 per share. | $3,200 | | 1-Oct-09 | BREITMEYER JAMES B Officer | 1,000 | Direct | Automatic Sale at $10.96 per share. | $10,960 | | 14-Sep-09 | SOCKS DAVID A Officer | 12,500 | Direct | Automatic Sale at $10.57 - $10.72 per share. | $133,0002 | | 10-Sep-09 | GARNER CAM L Director | 35,000 | Indirect | Sale at $11 per share. | $385,000 | | 1-Sep-09 | BREITMEYER JAMES B Officer | 1,000 | Direct | Option Exercise at $3.20 per share. | $3,200 | | 1-Sep-09 | BREITMEYER JAMES B Officer | 1,000 | Direct | Automatic Sale at $10.81 per share. | $10,810 | | 25-Aug-09 | CRAIG WILLIAM S Officer | 2,500 | Direct | Option Exercise at $0.40 per share. | $1,000 | | 25-Aug-09 | CRAIG WILLIAM S Officer | 2,500 | Direct | Automatic Sale at $11 per share. | $27,500 | | 20-Aug-09 | CRAIG WILLIAM S Officer | 5,000 | Direct | Option Exercise at $0.40 per share. | $2,000 | | 20-Aug-09 | CRAIG WILLIAM S Officer | 5,000 | Direct | Automatic Sale at $10.19 per share. | $50,950 | | 18-Aug-09 | BERMAN MICHAEL A Director | 1,000 | Direct | Acquisition (Non Open Market) at $9.94 per share. | $9,940 | | 17-Aug-09 | BERMAN MICHAEL A Director | 1,000 | Direct | Acquisition (Non Open Market) at $10.12 per share. | $10,120 | | 14-Aug-09 | BERMAN MICHAEL A Director | 2,500 | Direct | Acquisition (Non Open Market) at $10.58 per share. | $26,450 | | 12-Aug-09 | BERMAN MICHAEL A Director | 400 | Direct | Acquisition (Non Open Market) at $10.75 per share. | $4,300 | | 10-Aug-09 | SOCKS DAVID A Officer | 12,500 | Direct | Automatic Sale at $10.98 - $11 per share. | $137,0002 | | 10-Aug-09 | BERMAN MICHAEL A Director | 1,200 | Indirect | Acquisition (Non Open Market) at $10.90 per share. | $13,080 | | 10-Aug-09 | BERMAN MICHAEL A Director | 1,300 | Direct | Acquisition (Non Open Market) at $10.90 per share. | $14,170 | | 3-Aug-09 | BREITMEYER JAMES B Officer | 1,000 | Direct | Option Exercise at $3.20 per share. | $3,200 | | 3-Aug-09 | BREITMEYER JAMES B Officer | 1,000 | Direct | Automatic Sale at $12.11 per share. | $12,110 | | 20-Jul-09 | CRAIG WILLIAM S Officer | 7,500 | Direct | Option Exercise at $0.40 per share. | $3,000 | | 20-Jul-09 | CRAIG WILLIAM S Officer | 7,500 | Direct | Automatic Sale at $11 per share. | $82,500 | | 15-Jul-09 | CRAIG WILLIAM S Officer | 2,500 | Direct | Option Exercise at $0.40 per share. | $1,000 | | 15-Jul-09 | CRAIG WILLIAM S Officer | 2,500 | Direct | Automatic Sale at $11 per share. | $27,500 | | 13-Jul-09 | SOCKS DAVID A Officer | 12,500 | Direct | Automatic Sale at $10.33 per share. | $129,125 | | 24-Jun-09 | BYRD SCOTT A. Officer | N/A | Direct | Statement of Ownership | N/A | | 23-Jun-09 | CRAIG WILLIAM S Officer | 5,000 | Direct | Option Exercise at $0.40 per share. | $2,000 | | 23-Jun-09 | CRAIG WILLIAM S Officer | 5,000 | Direct | Automatic Sale at $8.72 per share. | $43,600 | | 20-May-09 | BERMAN MICHAEL A Director | 575 | Indirect | Acquisition (Non Open Market) at $9.57 - $9.59 per share. | $5,5082 | | 18-May-09 | BERMAN MICHAEL A Director | 8,200 | Direct | Acquisition (Non Open Market) at $9.58 per share. | $78,556 | | 18-Feb-09 | FRAZIER HEALTHCARE VI, L.P. Beneficial Owner (10% or more) | 3,128,258 | Direct | Statement of Ownership | N/A | | 18-Feb-09 | FRAZIER HEALTHCARE VI, L.P. Beneficial Owner (10% or more) | 3,128,258 | Indirect | Statement of Ownership | N/A | | 18-Feb-09 | DOMAIN PARTERS VII L P Beneficial Owner (10% or more) | 2,734,040 | Direct | Statement of Ownership | N/A | | 18-Feb-09 | DP VII ASSOCIATES LP Beneficial Owner (10% or more) | 46,634 | Direct | Statement of Ownership | N/A | | 18-Feb-09 | HALAK BRIAN K Beneficial Owner (10% or more) | 2,780,674 | Indirect | Purchase at $7.13 per share. | $19,826,205 | | 18-Feb-09 | SCHOEMAKER KATHLEEN K Beneficial Owner (10% or more) | 2,780,674 | Indirect | Purchase at $7.13 per share. | $19,826,205 | | 18-Feb-09 | BLAIR JAMES C Director | 2,780,674 | Indirect | Purchase at $7.13 per share. | $19,826,205 | | 18-Feb-09 | ATWOOD BRIAN G Director | 1,390,336 | Indirect | Acquisition (Non Open Market) at $7.13 per share. | $9,913,095 | | 18-Feb-09 | FRAZIER ALAN D Director | 3,475,842 | Indirect | Acquisition (Non Open Market) at $7.13 per share. | $24,782,753 | | 18-Feb-09 | TREU JESSE I Beneficial Owner (10% or more) | 2,780,674 | Indirect | Purchase at $7.13 per share. | $19,826,205 | | 18-Feb-09 | DOVEY BRIAN H Beneficial Owner (10% or more) | 2,780,674 | Indirect | Purchase at $7.13 per share. | $19,826,205 | | 18-Feb-09 | VITULLO NICOLE Beneficial Owner (10% or more) | 2,780,674 | Indirect | Purchase at $7.13 per share. | $19,826,205 | | 18-Feb-09 | FRAZIER HEALTHCARE V, LP Beneficial Owner (10% or more) | 3,475,842 | Direct | Purchase at $7.13 per share. | $24,782,753 | | 18-Feb-09 | FRAZIER HEALTHCARE V, LP Beneficial Owner (10% or more) | 6,951,684 | Indirect | Purchase at $7.13 per share. | $49,565,506 | | 26-Aug-08 | RICH TODD W Director | N/A | Direct | Statement of Ownership | N/A | | 16-May-08 | BERMAN MICHAEL A Director | 5,200 | Indirect | Purchase at $6.24 - $6.33 per share. | $33,0002 | | 16-May-08 | BERMAN MICHAEL A Director | 3,800 | Direct | Purchase at $6.33 per share. | $24,054 | | 15-May-08 | BERMAN MICHAEL A Director | 100 | Indirect | Purchase at $6.22 per share. | $622 | | 15-May-08 | BERMAN MICHAEL A Director | 1,000 | Direct | Purchase at $6.10 per share. | $6,100 | | 17-Mar-08 | BERMAN MICHAEL A Director | 10,000 | Direct | Purchase at $4.90 - $5.76 per share. | $53,0002 | | 17-Mar-08 | BARKER SAM L Director | 10,000 | Indirect | Purchase at $5.16 - $5.35 per share. | $53,0002 | | 17-Mar-08 | BARKER SAM L Director | 1,000 | Direct | Purchase at $5.37 per share. | $5,370 | | 20-Feb-08 | SCHROEDER THEODORE R Officer | 11,000 | Indirect | Acquisition (Non Open Market) at $5.34 per share. | $58,740 | | 20-Feb-08 | SOCKS DAVID A Officer | 3,745 | Direct | Acquisition (Non Open Market) at $5.34 per share. | $19,998 | | 20-Feb-08 | ROYAL MIKE A Officer | 2,000 | Direct | Acquisition (Non Open Market) at $5.34 per share. | $10,680 | | 20-Feb-08 | CRAIG WILLIAM S Officer | 2,000 | Direct | Acquisition (Non Open Market) at $5.34 per share. | $10,680 | | 20-Feb-08 | TWOMEY CHRISTOPHER J Director | 35,000 | Indirect | Acquisition (Non Open Market) at $5.34 per share. | $186,900 | | 20-Feb-08 | ATWOOD BRIAN G Director | 1,310,861 | Indirect | Acquisition (Non Open Market) at $5.34 per share. | $6,999,997 | | 20-Feb-08 | LARUE WILLIAM R Officer | 5,000 | Direct | Acquisition (Non Open Market) at $5.34 per share. | $26,700 | | 20-Feb-08 | AKER HAZEL M Officer | 3,745 | Direct | Acquisition (Non Open Market) at $5.34 per share. | $19,998 | | 20-Feb-08 | FRAZIER ALAN D Director | 1,872,659 | Indirect | Acquisition (Non Open Market) at $5.34 per share. | $9,999,999 | | 20-Feb-08 | FRAZIER HEALTHCARE V, LP Beneficial Owner (10% or more) | 4,372,659 | Indirect | Statement of Ownership | N/A | | 20-Feb-08 | BREITMEYER JAMES B Officer | 10,000 | Direct | Acquisition (Non Open Market) at $5.34 per share. | $53,400 | | 20-Feb-08 | GARNER CAM L Director | 37,453 | Indirect | Acquisition (Non Open Market) at $5.34 per share. | $199,999 | | 20-Feb-08 | DOMAIN PARTNERS VI, L.P. Beneficial Owner (10% or more) | 2,779,203 | Direct | Acquisition (Non Open Market) at $5.34 per share. | $14,840,944 | | 20-Feb-08 | DP VI ASSOCIATES, L.P. Beneficial Owner (10% or more) | 29,785 | Direct | Acquisition (Non Open Market) at $5.34 per share. | $159,051 | | 20-Feb-08 | MORE ROBERT J Beneficial Owner (10% or more) | 2,808,988 | Indirect | Acquisition (Non Open Market) at $5.34 per share. | $14,999,995 | | 20-Feb-08 | SCHOEMAKER KATHLEEN K Beneficial Owner (10% or more) | 2,808,988 | Indirect | Acquisition (Non Open Market) at $5.34 per share. | $14,999,995 | | 20-Feb-08 | BLAIR JAMES C Director | 2,808,988 | Indirect | Acquisition (Non Open Market) at $5.34 per share. | $14,999,995 | | 20-Feb-08 | TREU JESSE I Beneficial Owner (10% or more) | 2,808,988 | Indirect | Acquisition (Non Open Market) at $5.34 per share. | $14,999,995 | | 20-Feb-08 | DOVEY BRIAN H Beneficial Owner (10% or more) | 2,808,988 | Indirect | Acquisition (Non Open Market) at $5.34 per share. | $14,999,995 | | 20-Feb-08 | VITULLO NICOLE Beneficial Owner (10% or more) | 2,808,988 | Indirect | Acquisition (Non Open Market) at $5.34 per share. | $14,999,995 |
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* = Where indicated, some values are estimates. 1 = Potential proceeds estimated by the filer. 2 = Estimated based on the average of multiple prices reported. 3 = Multiple dates reported. Most recent date shown. |
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