| INSIDER TRANSACTIONS REPORTED - LAST TWO YEARS |
| Date | Insider | Shares | Type | Transaction | Value* | | 23-Nov-09 | TREMMEL JON T Director | 2,000 | Direct | Purchase at $0.58 per share. | $1,160 | | 5-Oct-09 | HUDSON BAY CAPITAL MANAGEMENT, L.P. Beneficial Owner (10% or more) | 196,774 | Indirect | Sale at $0.92 per share. | $181,032 | | 2-Oct-09 | HUDSON BAY CAPITAL MANAGEMENT, L.P. Beneficial Owner (10% or more) | 2,234,329 | Indirect | Sale at $1.02 per share. | $2,279,015 | | 2-Oct-09 | HUDSON BAY CAPITAL MANAGEMENT, L.P. Beneficial Owner (10% or more) | 6,161,068 | Indirect | Statement of Ownership | N/A | | 24-Feb-09 | ABERDARE VENTURES II, L.P. Beneficial Owner (10% or more) | 1,237,113 | Indirect | Purchase at $1.15 per share. | $1,422,679 | | 24-Feb-09 | KOSKINAS ELLEN E Director | 678,402 | Indirect | Purchase at $1.15 per share. | $780,162 | | 24-Feb-09 | KNUDSON MARK B Officer | 65,979 | Indirect | Purchase at $1.15 per share. | $75,875 | | 24-Feb-09 | LEA GREGORY S Officer | 16,495 | Direct | Purchase at $1.15 per share. | $18,969 | | 24-Feb-09 | KLINGENSTEIN PAUL H Director | 1,237,113 | Indirect | Purchase at $1.15 per share. | $1,422,679 | | 24-Feb-09 | GRIFFIN BOBBY IVAN Director | 206,186 | Direct | Purchase at $1.15 per share. | $237,113 | | 24-Feb-09 | MPM BIOVENTURES III QP LP Beneficial Owner (10% or more) | 1,765,499 | Indirect | Purchase at $1.15 per share. | $2,030,323 | | 24-Feb-09 | EVNIN LUKE Director | 1,765,499 | Indirect | Purchase at $1.15 per share. | $2,030,323 | | 24-Feb-09 | GADICKE ANSBERT Beneficial Owner (10% or more) | 1,765,499 | Indirect | Purchase at $1.15 per share. | $2,030,323 | | 19-Feb-09 | BAY CITY CAPITAL LLC Beneficial Owner (10% or more) | 1,649,485 | Direct | Purchase at $1.15 per share. | $1,896,907 | | 19-Feb-09 | GOLDFISCHER CARL Director | 1,649,485 | Indirect | Purchase at $1.15 per share. | $1,896,907 | | 5-Feb-09 | HARRISON DONALD C Director | 10,600 | Direct | Purchase at $1.24 per share. | $13,144 | | 28-Jan-09 | TREMMEL JON T Director | 6,156 | Direct | Statement of Ownership | N/A | | 17-Nov-08 | KNUDSON MARK B Officer | 848 | Indirect | Purchase at $1.75 per share. | $1,484 | | 14-Nov-08 | KNUDSON MARK B Officer | 152 | Indirect | Purchase at $1.48 per share. | $224 | | 29-Oct-08 | LEA GREGORY S Officer | 1,000 | Direct | Purchase at $1.15 per share. | $1,150 | | 28-Oct-08 | LEA GREGORY S Officer | 300 | Direct | Purchase at $1.50 per share. | $450 | | 27-Oct-08 | LEA GREGORY S Officer | 700 | Direct | Purchase at $1.30 per share. | $910 | | 24-Oct-08 | BAY CITY CAPITAL LLC Beneficial Owner (10% or more) | 49,600 | Direct | Purchase at $1.10 per share. | $54,560 | | 24-Oct-08 | GOLDFISCHER CARL Director | 49,600 | Indirect | Purchase at $1.10 per share. | $54,560 | | 31-Jul-08 | LEA GREGORY S Officer | 500 | Direct | Purchase at $4.08 - $4.1 per share. | $2,0452 | | 30-Jul-08 | LEA GREGORY S Officer | 500 | Direct | Purchase at $3.80 per share. | $1,900 | | 2-Jun-08 | ABERDARE VENTURES II, L.P. Beneficial Owner (10% or more) | 80,000 | Indirect | Purchase at $4.50 per share. | $360,000 | | 2-Jun-08 | KLINGENSTEIN PAUL H Director | 80,000 | Indirect | Purchase at $4.50 per share. | $360,000 | | 29-May-08 | ABERDARE VENTURES II, L.P. Beneficial Owner (10% or more) | 12,200 | Indirect | Purchase at $4.50 per share. | $54,900 | | 29-May-08 | KLINGENSTEIN PAUL H Director | 12,200 | Indirect | Purchase at $4.50 per share. | $54,900 | | 23-May-08 | ABERDARE VENTURES II, L.P. Beneficial Owner (10% or more) | 50,000 | Indirect | Purchase at $4.50 per share. | $225,000 | | 23-May-08 | KLINGENSTEIN PAUL H Director | 50,000 | Indirect | Purchase at $4.50 per share. | $225,000 | | 20-May-08 | ABERDARE VENTURES II, L.P. Beneficial Owner (10% or more) | 30,000 | Indirect | Purchase at $4.75 per share. | $142,500 | | 20-May-08 | KLINGENSTEIN PAUL H Director | 30,000 | Indirect | Purchase at $4.75 per share. | $142,500 | | 19-May-08 | ABERDARE VENTURES II, L.P. Beneficial Owner (10% or more) | 70,000 | Indirect | Purchase at $4.78 per share. | $334,600 | | 19-May-08 | KLINGENSTEIN PAUL H Director | 70,000 | Indirect | Purchase at $4.78 per share. | $334,600 | | 29-Apr-08 | BAY CITY CAPITAL LLC Beneficial Owner (10% or more) | 25,000 | Direct | Purchase at $4.50 per share. | $112,500 | | 29-Apr-08 | GOLDFISCHER CARL Director | 25,000 | Indirect | Purchase at $4.50 per share. | $112,500 | | 24-Apr-08 | BAY CITY CAPITAL LLC Beneficial Owner (10% or more) | 50,000 | Direct | Purchase at $4.50 per share. | $225,000 | | 24-Apr-08 | GOLDFISCHER CARL Director | 50,000 | Indirect | Purchase at $4.50 per share. | $225,000 | | 29-Feb-08 | BAY CITY CAPITAL LLC Beneficial Owner (10% or more) | 21,000 | Direct | Purchase at $8.66 per share. | $181,860 | | 29-Feb-08 | GOLDFISCHER CARL Director | 20,990 | Indirect | Purchase at $8.66 per share. | $181,773 |
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* = Where indicated, some values are estimates. 1 = Potential proceeds estimated by the filer. 2 = Estimated based on the average of multiple prices reported. 3 = Multiple dates reported. Most recent date shown. |
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