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| NET SHARE PURCHASE ACTIVITY |
| Insider Purchases - Last 6 Months | | | Shares | Trans | | Purchases | N/A | 0 | | Sales | N/A | 0 | Net Shares Purchased (Sold) | N/A | 0 | | Total Insider Shares Held | 17.78M |
N/A
| % Net Shares Purchased (Sold) | 0.0% |
N/A
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| Net Institutional Purchases - Prior Qtr to Latest Qtr | | | Shares | | Net Shares Purchased (Sold) | (2,941,930) | | % Change in Institutional Shares Held | (118.7%) |
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| INSIDER TRANSACTIONS REPORTED - LAST TWO YEARS |
| Date | Insider | Shares | Type | Transaction | Value* | | 24-May-06 | ORBIMED ADVISORS LLC Director | 22,500 | Indirect | Sale at $18.14 - $18.14 per share. | $408,0002 |
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* = Where indicated, some values are estimates. 1 = Potential proceeds estimated by the filer. 2 = Estimated based on the average of multiple prices reported. 3 = Multiple dates reported. Most recent date shown. |
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