| INSIDER TRANSACTIONS REPORTED - LAST TWO YEARS |
| Date | Insider | Shares | Type | Transaction | Value* | | 25-Jan-07 | 14159 CAPITAL (GP), LLC Beneficial Owner (10% or more) | 1,164 | Indirect | Purchase at $6 - $6 per share. | $6,9842 | | 25-Jan-07 | BAKER BROTHERS LIFE SCIENCES CAPITAL (GP), LLC Beneficial Owner (10% or more) | 35,469 | Indirect | Purchase at $6 - $6 per share. | $213,0002 | | 25-Jan-07 | BAKER BIOTECH CAPITAL (GP), LLC Beneficial Owner (10% or more) | 12,701 | Indirect | Purchase at $6 - $6 per share. | $76,0002 | | 24-Jan-07 | 14159 CAPITAL (GP), LLC Beneficial Owner (10% or more) | 388 | Indirect | Purchase at $5.98 - $5.98 per share. | $2,3202 | | 24-Jan-07 | BAKER BROTHERS LIFE SCIENCES CAPITAL (GP), LLC Beneficial Owner (10% or more) | 11,847 | Indirect | Purchase at $5.98 - $5.98 per share. | $71,0002 | | 24-Jan-07 | BAKER BIOTECH CAPITAL (GP), LLC Beneficial Owner (10% or more) | 4,242 | Indirect | Purchase at $5.98 - $5.98 per share. | $25,0002 | | 11-Jan-07 | 14159 CAPITAL (GP), LLC Beneficial Owner (10% or more) | 1,864 | Indirect | Purchase at $5.28 - $5.28 per share. | $9,8412 | | 11-Jan-07 | BAKER BROTHERS LIFE SCIENCES CAPITAL (GP), LLC Beneficial Owner (10% or more) | 56,822 | Indirect | Purchase at $5.28 - $5.28 per share. | $300,0002 | | 11-Jan-07 | BAKER BIOTECH CAPITAL (GP), LLC Beneficial Owner (10% or more) | 20,347 | Indirect | Purchase at $5.28 - $5.28 per share. | $107,0002 | | 10-Jan-07 | 14159 CAPITAL (GP), LLC Beneficial Owner (10% or more) | 581 | Indirect | Purchase at $4.83 - $4.83 per share. | $2,8062 | | 10-Jan-07 | BAKER BROTHERS LIFE SCIENCES CAPITAL (GP), LLC Beneficial Owner (10% or more) | 17,735 | Indirect | Purchase at $4.83 - $4.83 per share. | $86,0002 | | 10-Jan-07 | BAKER BIOTECH CAPITAL (GP), LLC Beneficial Owner (10% or more) | 6,351 | Indirect | Purchase at $4.83 - $4.83 per share. | $31,0002 | | 9-Jan-07 | 14159 CAPITAL (GP), LLC Beneficial Owner (10% or more) | 817 | Indirect | Purchase at $4.77 - $4.77 per share. | $3,8972 | | 9-Jan-07 | BAKER BROTHERS LIFE SCIENCES CAPITAL (GP), LLC Beneficial Owner (10% or more) | 24,899 | Indirect | Purchase at $4.77 - $4.77 per share. | $119,0002 | | 9-Jan-07 | BAKER BIOTECH CAPITAL (GP), LLC Beneficial Owner (10% or more) | 8,917 | Indirect | Purchase at $4.77 - $4.77 per share. | $43,0002 | | 5-Jan-07 | TANG KEVIN C Director | 94,700 | Indirect | Purchase at $4.50 - $4.5 per share. | $426,0002 | | 4-Jan-07 | TANG KEVIN C Director | 28,732 | Indirect | Purchase at $4.33 - $4.33 per share. | $124,0002 | | 3-Jan-07 | TANG KEVIN C Director | 8,300 | Indirect | Purchase at $4.21 - $4.21 per share. | $35,0002 |
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* = Where indicated, some values are estimates. 1 = Potential proceeds estimated by the filer. 2 = Estimated based on the average of multiple prices reported. 3 = Multiple dates reported. Most recent date shown. |
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