| INSIDER TRANSACTIONS REPORTED - LAST TWO YEARS |
| Date | Insider | Shares | Type | Transaction | Value* | | 24-Nov-09 | MUELLER HANS Director | 4,000 | Direct | Purchase at $5.10 per share. | $20,400 | | 12-Nov-09 | MUELLER HANS Director | 2,000 | Direct | Purchase at $5.17 per share. | $10,340 | | 4-Aug-09 | MUELLER HANS Director | 1,500 | Direct | Purchase at $6.82 per share. | $10,230 | | 25-Jun-09 | AGRAWAL SUDHIR Officer | 6,615 | Direct | Disposition (Non Open Market) at $6.18 per share. | $40,880 | | 29-May-09 | ZEIN YOUSSEF EL Director | 1,000 | Direct | Option Exercise at $4 per share. | $4,000 | | 8-May-09 | MUELLER HANS Director | 2,500 | Direct | Purchase at $6.09 per share. | $15,225 | | 24-Apr-09 | ZEIN YOUSSEF EL Director | 125 | Direct | Option Exercise at $4 per share. | $500 | | 1-Apr-09 | REARDON WILLIAM S Director | 1,070 | Direct | Acquisition (Non Open Market) at $6.25 per share. | $6,687 | | 16-Mar-09 | ZEIN YOUSSEF EL Director | 44,483 | Direct | Sale at $5.62 per share. | $249,994 | | 14-Jan-09 | ZEIN YOUSSEF EL Director | 22,300 | Direct | Automatic Sale at $8.48 per share. | $189,104 | | 13-Jan-09 | ZEIN YOUSSEF EL Director | 5,500 | Direct | Automatic Sale at $8.34 per share. | $45,870 | | 12-Jan-09 | ZEIN YOUSSEF EL Director | 6,300 | Direct | Automatic Sale at $8.27 per share. | $52,101 | | 24-Dec-08 | AGRAWAL SUDHIR Officer | 4,285 | Direct | Automatic Sale at $7.48 per share. | $32,051 | | 23-Dec-08 | AGRAWAL SUDHIR Officer | 1,500 | Direct | Automatic Sale at $7.57 per share. | $11,355 | | 22-Dec-08 | ZEIN YOUSSEF EL Director | 8,400 | Direct | Automatic Sale at $8.25 per share. | $69,300 | | 22-Dec-08 | AGRAWAL SUDHIR Officer | 2,800 | Direct | Automatic Sale at $7.41 - $8.38 per share. | $22,0002 | | 19-Dec-08 | AGRAWAL SUDHIR Officer | 9,887 | Direct | Automatic Sale at $8.51 per share. | $84,138 | | 18-Dec-08 | AGRAWAL SUDHIR Officer | 28,069 | Direct | Option Exercise at $4 per share. | $112,276 | | 18-Dec-08 | AGRAWAL SUDHIR Officer | 13,418 | Direct | Automatic Sale at $8.55 per share. | $114,723 | | 17-Dec-08 | AGRAWAL SUDHIR Officer | 14,377 | Direct | Option Exercise at $4 per share. | $57,508 | | 17-Dec-08 | AGRAWAL SUDHIR Officer | 6,715 | Direct | Automatic Sale at $8.64 per share. | $58,017 | | 5-Sep-08 | ZEIN YOUSSEF EL Director | 70,684 | Direct | Option Exercise at $7.12 per share. | $503,270 | | 29-Jul-08 | BAKER BROS. CAPITAL (GP), LLC Beneficial Owner (10% or more) | 1,885 | Indirect | Sale at $14.93 per share. | $28,143 | | 29-Jul-08 | 14159 CAPITAL (GP), LLC Beneficial Owner (10% or more) | 606 | Indirect | Sale at $14.93 per share. | $9,047 | | 29-Jul-08 | BAKER BROTHERS LIFE SCIENCES CAPITAL (GP), LLC Beneficial Owner (10% or more) | 19,670 | Indirect | Sale at $14.93 per share. | $293,673 | | 29-Jul-08 | BAKER BROTHERS LIFE SCIENCES CAPITAL (GP), LLC Beneficial Owner (10% or more) | 19,670 | Indirect | Sale at $14.93 per share. | $293,673 | | 29-Jul-08 | BAKER BIOTECH CAPITAL (GP), LLC Beneficial Owner (10% or more) | 9,839 | Indirect | Sale at $14.93 per share. | $146,896 | | 28-Jul-08 | BAKER BROTHERS LIFE SCIENCES CAPITAL (GP), LLC Beneficial Owner (10% or more) | 5,901 | Indirect | Sale at $14.87 per share. | $87,747 | | 28-Jul-08 | BAKER BROTHERS LIFE SCIENCES CAPITAL (GP), LLC Beneficial Owner (10% or more) | 5,901 | Indirect | Sale at $14.87 per share. | $87,747 | | 28-Jul-08 | BAKER BROS. CAPITAL (GP), LLC Beneficial Owner (10% or more) | 565 | Indirect | Sale at $14.87 per share. | $8,401 | | 28-Jul-08 | 14159 CAPITAL (GP), LLC Beneficial Owner (10% or more) | 182 | Indirect | Sale at $14.87 per share. | $2,706 | | 28-Jul-08 | BAKER BIOTECH CAPITAL (GP), LLC Beneficial Owner (10% or more) | 2,952 | Indirect | Sale at $14.87 per share. | $43,896 | | 25-Jul-08 | BAKER BROS. CAPITAL (GP), LLC Beneficial Owner (10% or more) | 1,768 | Indirect | Sale at $15.01 per share. | $26,537 | | 25-Jul-08 | BAKER BIOTECH CAPITAL (GP), LLC Beneficial Owner (10% or more) | 9,224 | Indirect | Sale at $15.01 per share. | $138,452 | | 25-Jul-08 | 14159 CAPITAL (GP), LLC Beneficial Owner (10% or more) | 568 | Indirect | Sale at $15.01 per share. | $8,525 | | 25-Jul-08 | BAKER BROTHERS LIFE SCIENCES CAPITAL (GP), LLC Beneficial Owner (10% or more) | 18,440 | Indirect | Sale at $15.01 per share. | $276,784 | | 24-Jul-08 | BAKER BROS. CAPITAL (GP), LLC Beneficial Owner (10% or more) | 2,947 | Indirect | Sale at $15.02 per share. | $44,263 | | 24-Jul-08 | BAKER BIOTECH CAPITAL (GP), LLC Beneficial Owner (10% or more) | 15,374 | Indirect | Sale at $15.02 per share. | $230,917 | | 24-Jul-08 | 14159 CAPITAL (GP), LLC Beneficial Owner (10% or more) | 945 | Indirect | Sale at $15.02 per share. | $14,193 | | 24-Jul-08 | BAKER BROTHERS LIFE SCIENCES CAPITAL (GP), LLC Beneficial Owner (10% or more) | 30,734 | Indirect | Sale at $15.02 per share. | $461,624 | | 23-Jul-08 | BAKER BROS. CAPITAL (GP), LLC Beneficial Owner (10% or more) | 1,886 | Indirect | Sale at $14.86 per share. | $28,025 | | 23-Jul-08 | BAKER BIOTECH CAPITAL (GP), LLC Beneficial Owner (10% or more) | 9,839 | Indirect | Sale at $14.86 per share. | $146,207 | | 23-Jul-08 | 14159 CAPITAL (GP), LLC Beneficial Owner (10% or more) | 605 | Indirect | Sale at $14.86 per share. | $8,990 | | 23-Jul-08 | BAKER BROTHERS LIFE SCIENCES CAPITAL (GP), LLC Beneficial Owner (10% or more) | 19,670 | Indirect | Sale at $14.86 per share. | $292,296 | | 17-Jul-08 | 14159 CAPITAL (GP), LLC Beneficial Owner (10% or more) | 1,136 | Indirect | Sale at $14.80 per share. | $16,812 | | 17-Jul-08 | BAKER BROTHERS LIFE SCIENCES CAPITAL (GP), LLC Beneficial Owner (10% or more) | 36,880 | Indirect | Sale at $14.80 per share. | $545,824 | | 17-Jul-08 | BAKER BROS. CAPITAL (GP), LLC Beneficial Owner (10% or more) | 3,535 | Indirect | Sale at $14.80 per share. | $52,318 | | 17-Jul-08 | BAKER BIOTECH CAPITAL (GP), LLC Beneficial Owner (10% or more) | 18,449 | Indirect | Sale at $14.80 per share. | $273,045 | | 14-Jul-08 | 14159 CAPITAL (GP), LLC Beneficial Owner (10% or more) | 527 | Indirect | Sale at $15.24 per share. | $8,031 | | 14-Jul-08 | BAKER BROTHERS LIFE SCIENCES CAPITAL (GP), LLC Beneficial Owner (10% or more) | 17,149 | Indirect | Sale at $15.24 per share. | $261,350 | | 14-Jul-08 | BAKER BROS. CAPITAL (GP), LLC Beneficial Owner (10% or more) | 1,645 | Indirect | Sale at $15.24 per share. | $25,069 | | 14-Jul-08 | BAKER BIOTECH CAPITAL (GP), LLC Beneficial Owner (10% or more) | 8,579 | Indirect | Sale at $15.24 per share. | $130,743 | | 8-Jul-08 | AGRAWAL SUDHIR Officer | 18,769 | Direct | Option Exercise at $4 per share. | $75,076 | | 8-Jul-08 | AGRAWAL SUDHIR Officer | 7,986 | Direct | Automatic Sale at $13.34 - $14 per share. | $109,0002 | | 7-Jul-08 | AGRAWAL SUDHIR Officer | 63,784 | Direct | Option Exercise at $4 per share. | $255,136 | | 7-Jul-08 | AGRAWAL SUDHIR Officer | 27,600 | Direct | Automatic Sale at $13.11 per share. | $361,836 | | 1-Jul-08 | 14159 CAPITAL (GP), LLC Beneficial Owner (10% or more) | 302 | Indirect | Sale at $14.51 per share. | $4,382 | | 1-Jul-08 | BAKER BROTHERS LIFE SCIENCES CAPITAL (GP), LLC Beneficial Owner (10% or more) | 9,835 | Indirect | Sale at $14.51 per share. | $142,705 | | 1-Jul-08 | BAKER BROS. CAPITAL (GP), LLC Beneficial Owner (10% or more) | 943 | Indirect | Sale at $14.51 per share. | $13,682 | | 1-Jul-08 | BAKER BIOTECH CAPITAL (GP), LLC Beneficial Owner (10% or more) | 4,920 | Indirect | Sale at $14.51 per share. | $71,389 | | 30-Jun-08 | 14159 CAPITAL (GP), LLC Beneficial Owner (10% or more) | 776 | Indirect | Sale at $14.99 per share. | $11,632 | | 30-Jun-08 | BAKER BROTHERS LIFE SCIENCES CAPITAL (GP), LLC Beneficial Owner (10% or more) | 25,202 | Indirect | Sale at $14.99 per share. | $377,777 | | 30-Jun-08 | BAKER BROS. CAPITAL (GP), LLC Beneficial Owner (10% or more) | 2,416 | Indirect | Sale at $14.99 per share. | $36,215 | | 30-Jun-08 | BAKER BIOTECH CAPITAL (GP), LLC Beneficial Owner (10% or more) | 12,606 | Indirect | Sale at $14.99 per share. | $188,963 | | 27-Jun-08 | 14159 CAPITAL (GP), LLC Beneficial Owner (10% or more) | 10,207 | Indirect | Sale at $15.41 per share. | $157,289 | | 27-Jun-08 | BAKER BROTHERS LIFE SCIENCES CAPITAL (GP), LLC Beneficial Owner (10% or more) | 331,598 | Indirect | Sale at $15.41 per share. | $5,109,925 | | 27-Jun-08 | BAKER BROS. CAPITAL (GP), LLC Beneficial Owner (10% or more) | 31,791 | Indirect | Sale at $15.41 per share. | $489,899 | | 27-Jun-08 | BAKER BIOTECH CAPITAL (GP), LLC Beneficial Owner (10% or more) | 165,874 | Indirect | Sale at $15.41 per share. | $2,556,118 | | 25-Jun-08 | AGRAWAL SUDHIR Officer | 6,594 | Direct | Disposition (Non Open Market) at $14.44 per share. | $95,217 | | 16-Jun-08 | ZEIN YOUSSEF EL Director | 168,463 | Indirect | Acquisition (Non Open Market) at $0 per share. | N/A | | 16-Jun-08 | ZEIN YOUSSEF EL Director | 800,431 | Indirect | Disposition (Non Open Market) at $0 per share. | N/A | | 12-Jun-08 | WYNGAARDEN JAMES B Director | 1,284 | Direct | Sale at $14.50 per share. | $18,618 | | 10-Jun-08 | WYNGAARDEN JAMES B Director | 1,284 | Direct | Option Exercise at $8 per share. | $10,272 | | 29-May-08 | ZEIN YOUSSEF EL Director | 206,264 | Indirect | Option Exercise at $8 per share. | $1,650,112 | | 29-May-08 | ZEIN YOUSSEF EL Director | 73,464 | Direct | Option Exercise at $8 per share. | $587,712 | | 29-May-08 | ZEIN YOUSSEF EL Director | 111,148 | Indirect | Disposition (Non Open Market) at $14.85 per share. | $1,650,547 | | 29-May-08 | ZEIN YOUSSEF EL Director | 39,587 | Direct | Disposition (Non Open Market) at $14.85 per share. | $587,866 | | 16-May-08 | WYNGAARDEN JAMES B Director | 5,990 | Direct | Option Exercise at $4 per share. | $23,960 | | 16-May-08 | WYNGAARDEN JAMES B Director | 5,990 | Direct | Sale at $14.79 per share. | $88,592 | | 15-May-08 | SULLIVAN TIMOTHY M Officer | 4,200 | Direct | Sale at $14.95 per share. | $62,790 | | 4-Apr-08 | ZEIN YOUSSEF EL Director | 24,066 | Indirect | Acquisition (Non Open Market) at $0 per share. | N/A | | 4-Apr-08 | ZEIN YOUSSEF EL Director | 283,397 | Indirect | Disposition (Non Open Market) at $0 per share. | N/A | | 28-Mar-08 | ZEIN YOUSSEF EL Director | 69,202 | Indirect | Option Exercise at $5.36 per share. | $370,922 | | 14-Mar-08 | BEXON ALICE Officer | 27,499 | Direct | Option Exercise at $7.55 per share. | $207,617 | | 14-Mar-08 | BEXON ALICE Officer | 27,499 | Direct | Sale at $9.48 per share. | $260,690 | | 14-Mar-08 | ZEIN YOUSSEF EL Director | 54,065 | Indirect | Option Exercise at $5.36 per share. | $289,788 | | 14-Mar-08 | ZEIN YOUSSEF EL Director | 54,065 | Direct | Acquisition (Non Open Market) at $0 per share. | N/A | | 14-Mar-08 | ZEIN YOUSSEF EL Director | 54,065 | Indirect | Disposition (Non Open Market) at $0 per share. | N/A | | 14-Mar-08 | WYNGAARDEN JAMES B Director | 10,306 | Direct | Option Exercise at $4 per share. | $41,224 | | 14-Mar-08 | WYNGAARDEN JAMES B Director | 10,306 | Direct | Sale at $10.04 per share. | $103,472 | | 13-Mar-08 | WYNGAARDEN JAMES B Director | 9,704 | Direct | Option Exercise at $4 per share. | $38,816 | | 13-Mar-08 | WYNGAARDEN JAMES B Director | 9,704 | Direct | Sale at $10 per share. | $97,040 | | 25-Jan-08 | ZEIN YOUSSEF EL Director | 17,828 | Indirect | Acquisition (Non Open Market) at $0 per share. | N/A | | 25-Jan-08 | ZEIN YOUSSEF EL Director | 217,120 | Indirect | Disposition (Non Open Market) at $0 per share. | N/A | | 10-Jan-08 | 14159 CAPITAL (GP), LLC Beneficial Owner (10% or more) | 13 | Indirect | Sale at $13 per share. | $169 | | 10-Jan-08 | BAKER BROTHERS LIFE SCIENCES CAPITAL (GP), LLC Beneficial Owner (10% or more) | 430 | Indirect | Sale at $13 per share. | $5,590 | | 10-Jan-08 | BAKER BROS. CAPITAL (GP), LLC Beneficial Owner (10% or more) | 42 | Indirect | Sale at $13 per share. | $546 | | 10-Jan-08 | BAKER BIOTECH CAPITAL (GP), LLC Beneficial Owner (10% or more) | 215 | Indirect | Sale at $13 per share. | $2,795 | | 9-Jan-08 | 14159 CAPITAL (GP), LLC Beneficial Owner (10% or more) | 68 | Indirect | Sale at $13 per share. | $884 | | 9-Jan-08 | BAKER BROTHERS LIFE SCIENCES CAPITAL (GP), LLC Beneficial Owner (10% or more) | 2,213 | Indirect | Sale at $13 per share. | $28,769 | | 9-Jan-08 | BAKER BROS. CAPITAL (GP), LLC Beneficial Owner (10% or more) | 212 | Indirect | Sale at $13 per share. | $2,756 | | 9-Jan-08 | BAKER BIOTECH CAPITAL (GP), LLC Beneficial Owner (10% or more) | 1,107 | Indirect | Sale at $13 per share. | $14,391 | | 8-Jan-08 | 14159 CAPITAL (GP), LLC Beneficial Owner (10% or more) | 3 | Indirect | Sale at $13 per share. | $39 | | 8-Jan-08 | BAKER BROTHERS LIFE SCIENCES CAPITAL (GP), LLC Beneficial Owner (10% or more) | 61 | Indirect | Sale at $13 per share. | $793 | | 8-Jan-08 | BAKER BROS. CAPITAL (GP), LLC Beneficial Owner (10% or more) | 5 | Indirect | Sale at $13 per share. | $65 | | 8-Jan-08 | BAKER BIOTECH CAPITAL (GP), LLC Beneficial Owner (10% or more) | 31 | Indirect | Sale at $13 per share. | $403 | | 7-Jan-08 | 14159 CAPITAL (GP), LLC Beneficial Owner (10% or more) | 3 | Indirect | Sale at $13 per share. | $39 | | 7-Jan-08 | BAKER BROTHERS LIFE SCIENCES CAPITAL (GP), LLC Beneficial Owner (10% or more) | 61 | Indirect | Sale at $13 per share. | $793 | | 7-Jan-08 | BAKER BROS. CAPITAL (GP), LLC Beneficial Owner (10% or more) | 5 | Indirect | Sale at $13 per share. | $65 | | 7-Jan-08 | BAKER BIOTECH CAPITAL (GP), LLC Beneficial Owner (10% or more) | 31 | Indirect | Sale at $13 per share. | $403 | | 4-Jan-08 | 14159 CAPITAL (GP), LLC Beneficial Owner (10% or more) | 332 | Indirect | Sale at $13.14 per share. | $4,362 | | 4-Jan-08 | BAKER BROTHERS LIFE SCIENCES CAPITAL (GP), LLC Beneficial Owner (10% or more) | 10,757 | Indirect | Sale at $13.14 per share. | $141,346 | | 4-Jan-08 | BAKER BROS. CAPITAL (GP), LLC Beneficial Owner (10% or more) | 1,031 | Indirect | Sale at $13.14 per share. | $13,547 | | 4-Jan-08 | BAKER BIOTECH CAPITAL (GP), LLC Beneficial Owner (10% or more) | 5,380 | Indirect | Sale at $13.14 per share. | $70,693 | | 3-Jan-08 | 14159 CAPITAL (GP), LLC Beneficial Owner (10% or more) | 317 | Indirect | Sale at $13.29 per share. | $4,212 | | 3-Jan-08 | BAKER BROTHERS LIFE SCIENCES CAPITAL (GP), LLC Beneficial Owner (10% or more) | 10,327 | Indirect | Sale at $13.29 per share. | $137,245 | | 3-Jan-08 | BAKER BROS. CAPITAL (GP), LLC Beneficial Owner (10% or more) | 990 | Indirect | Sale at $13.29 per share. | $13,157 | | 3-Jan-08 | BAKER BIOTECH CAPITAL (GP), LLC Beneficial Owner (10% or more) | 5,166 | Indirect | Sale at $13.29 per share. | $68,656 | | 2-Jan-08 | 14159 CAPITAL (GP), LLC Beneficial Owner (10% or more) | 945 | Indirect | Sale at $12.94 per share. | $12,228 | | 2-Jan-08 | BAKER BROTHERS LIFE SCIENCES CAPITAL (GP), LLC Beneficial Owner (10% or more) | 30,734 | Indirect | Sale at $12.94 per share. | $397,697 | | 2-Jan-08 | BAKER BROS. CAPITAL (GP), LLC Beneficial Owner (10% or more) | 2,947 | Indirect | Sale at $12.94 per share. | $38,134 | | 2-Jan-08 | BAKER BIOTECH CAPITAL (GP), LLC Beneficial Owner (10% or more) | 15,374 | Indirect | Sale at $12.94 per share. | $198,939 | | 2-Jan-08 | REARDON WILLIAM S Director | 155 | Direct | Purchase at $11.29 per share. | $1,749 | | 2-Jan-08 | ZAMECNIK PAUL C Other | 443 | Direct | Purchase at $11.29 per share. | $5,001 | | 2-Jan-08 | WYNGAARDEN JAMES B Director | 465 | Direct | Purchase at $11.29 per share. | $5,249 |
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* = Where indicated, some values are estimates. 1 = Potential proceeds estimated by the filer. 2 = Estimated based on the average of multiple prices reported. 3 = Multiple dates reported. Most recent date shown. |
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