| INSIDER TRANSACTIONS REPORTED - LAST TWO YEARS |
| Date | Insider | Shares | Type | Transaction | Value* | | 25-Nov-09 | QVT ASSOCIATES GP LLC Beneficial Owner (10% or more) | 300 | Indirect | Purchase at $1 per share. | $300 | | 24-Nov-09 | QVT ASSOCIATES GP LLC Beneficial Owner (10% or more) | 16,292 | Indirect | Purchase at $0.98 per share. | $15,966 | | 23-Nov-09 | QVT ASSOCIATES GP LLC Beneficial Owner (10% or more) | 13,000 | Indirect | Purchase at $0.99 per share. | $12,870 | | 20-Nov-09 | QVT ASSOCIATES GP LLC Beneficial Owner (10% or more) | 11,700 | Indirect | Purchase at $0.99 per share. | $11,583 | | 19-Nov-09 | QVT ASSOCIATES GP LLC Beneficial Owner (10% or more) | 11,000 | Indirect | Purchase at $0.98 per share. | $10,780 | | 18-Nov-09 | QVT ASSOCIATES GP LLC Beneficial Owner (10% or more) | 85,000 | Indirect | Purchase at $0.99 per share. | $84,150 | | 17-Nov-09 | QVT ASSOCIATES GP LLC Beneficial Owner (10% or more) | 9,500 | Indirect | Purchase at $0.98 per share. | $9,310 | | 12-Nov-09 | QVT ASSOCIATES GP LLC Beneficial Owner (10% or more) | 19,000 | Indirect | Purchase at $0.99 per share. | $18,810 | | 11-Nov-09 | QVT ASSOCIATES GP LLC Beneficial Owner (10% or more) | 100,000 | Indirect | Purchase at $1 per share. | $100,000 | | 10-Nov-09 | QVT ASSOCIATES GP LLC Beneficial Owner (10% or more) | 13,000 | Indirect | Purchase at $1 per share. | $13,000 | | 9-Nov-09 | QVT ASSOCIATES GP LLC Beneficial Owner (10% or more) | 71,000 | Indirect | Purchase at $0.99 per share. | $70,290 | | 6-Nov-09 | QVT ASSOCIATES GP LLC Beneficial Owner (10% or more) | 46,000 | Indirect | Purchase at $0.99 per share. | $45,540 | | 5-Nov-09 | QVT ASSOCIATES GP LLC Beneficial Owner (10% or more) | 48,000 | Indirect | Purchase at $0.99 per share. | $47,520 | | 4-Nov-09 | QVT ASSOCIATES GP LLC Beneficial Owner (10% or more) | 79,000 | Indirect | Purchase at $1 per share. | $79,000 | | 3-Nov-09 | QVT ASSOCIATES GP LLC Beneficial Owner (10% or more) | 55,000 | Indirect | Purchase at $0.99 per share. | $54,450 | | 2-Nov-09 | QVT ASSOCIATES GP LLC Beneficial Owner (10% or more) | 17,480 | Indirect | Purchase at $0.97 - $0.99 per share. | $17,0002 | | 30-Oct-09 | QVT ASSOCIATES GP LLC Beneficial Owner (10% or more) | 27,556 | Indirect | Purchase at $0.99 per share. | $27,280 | | 28-Oct-09 | TRAINOR III EUGENE A Beneficial Owner (10% or more) | 2,343,749 | Indirect | Purchase at $1.28 per share. | $2,999,998 | | 28-Oct-09 | SANDELL SCOTT D Beneficial Owner (10% or more) | 2,343,749 | Indirect | Purchase at $1.28 per share. | $2,999,998 | | 28-Oct-09 | NEWHALL CHARLES W III Beneficial Owner (10% or more) | 2,343,749 | Indirect | Purchase at $1.28 per share. | $2,999,998 | | 28-Oct-09 | BARRIS PETER J Beneficial Owner (10% or more) | 2,343,749 | Indirect | Purchase at $1.28 per share. | $2,999,998 | | 28-Oct-09 | PERRY MARK W Beneficial Owner (10% or more) | 2,343,749 | Indirect | Purchase at $1.28 per share. | $2,999,998 | | 28-Oct-09 | BARRETT M JAMES Director | 2,343,749 | Indirect | Purchase at $1.28 per share. | $2,999,998 | | 28-Oct-09 | NEW ENTERPRISE ASSOCIATES 10 L P Beneficial Owner (10% or more) | 1,757,812 | Direct | Purchase at $1.28 per share. | $2,249,999 | | 28-Oct-09 | KRAMLICH C RICHARD Beneficial Owner (10% or more) | 2,343,749 | Indirect | Purchase at $1.28 per share. | $2,999,998 | | 22-Oct-09 | QVT ASSOCIATES GP LLC Beneficial Owner (10% or more) | 8,203,125 | Indirect | Statement of Ownership | N/A | | 6-Jan-09 | PLUMB RUSSELL H Officer | 10,710 | Direct | Disposition (Non Open Market) at $0.30 per share. | $3,213 | | 30-Dec-08 | BVF PARTNERS L P/IL Beneficial Owner (10% or more) | 5,644,723 | Indirect | Statement of Ownership | N/A | | 30-Dec-08 | BVF PARTNERS L P/IL Beneficial Owner (10% or more) | 3,339,064 | Direct | Statement of Ownership | N/A | | 3-Dec-08 | HENSON GEOFFREY W. Officer | 140,000 | Direct | Purchase at $0.25 per share. | $35,000 | | 2-Dec-08 | PLUMB RUSSELL H Officer | 7,400 | Direct | Purchase at $0.24 per share. | $1,776 | | 25-Nov-08 | PLUMB RUSSELL H Officer | 5,600 | Direct | Purchase at $0.25 per share. | $1,400 | | 20-Nov-08 | PLUMB RUSSELL H Officer | 16,600 | Direct | Purchase at $0.21 per share. | $3,486 | | 14-Nov-08 | PATTI JOSEPH M Officer | 20,000 | Direct | Purchase at $0.22 per share. | $4,400 | | 3-Jul-08 | HAMM ROBERT A Director | 14,698 | Direct | Disposition (Non Open Market) at $0.66 per share. | $9,700 | | 3-Jul-08 | PREMINGER MARC L Director | 19,667 | Direct | Disposition (Non Open Market) at $0.66 per share. | $12,980 | | 3-Jul-08 | MEDFORD RUSSELL M Director | 14,698 | Direct | Disposition (Non Open Market) at $0.66 per share. | $9,700 | | 3-Jul-08 | HENOS MICHAEL A Director | 30,796 | Direct | Disposition (Non Open Market) at $0.66 per share. | $20,325 | | 25-Apr-08 | PLUMB RUSSELL H Officer | 17,064 | Direct | Disposition (Non Open Market) at $0.66 per share. | $11,262 | | 25-Apr-08 | PATTI JOSEPH M Officer | 18,254 | Direct | Disposition (Non Open Market) at $0.66 per share. | $12,047 | | 4-Apr-08 | PLUMB RUSSELL H Officer | 49,630 | Direct | Disposition (Non Open Market) at $0.71 per share. | $35,237 | | 17-Mar-08 | CERRONE GABRIEL Director | 435,600 | Indirect | Acquisition (Non Open Market) at $0 per share. | N/A | | 17-Mar-08 | CERRONE GABRIEL Director | 435,600 | Direct | Disposition (Non Open Market) at $0 per share. | N/A | | 31-Dec-07 | HENOS MICHAEL A Director | 163 | Indirect | Disposition (Non Open Market) at $0.78 per share. | $127 | | 31-Dec-07 | HENOS MICHAEL A Director | 163 | Direct | Acquisition (Non Open Market) at $0.78 per share. | $127 |
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* = Where indicated, some values are estimates. 1 = Potential proceeds estimated by the filer. 2 = Estimated based on the average of multiple prices reported. 3 = Multiple dates reported. Most recent date shown. |
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