| INSIDER TRANSACTIONS REPORTED - LAST TWO YEARS |
| Date | Insider | Shares | Type | Transaction | Value* | | 18-Nov-08 | MATRICARIA RONALD A Director | 11,700 | Direct | Purchase at $24.69 per share. | $288,873 | | 17-Nov-08 | MATRICARIA RONALD A Director | 18,300 | Direct | Purchase at $24.50 - $25 per share. | $453,0002 | | 14-Nov-08 | BRUST BERND Officer | 2,000 | Direct | Option Exercise at $0 per share. | N/A | | 14-Nov-08 | BRUST BERND Officer | 715 | Direct | Disposition (Non Open Market) at $25.05 per share. | $17,910 | | 14-Nov-08 | LEDDY PETER MICHAEL Officer | 2,000 | Direct | Option Exercise at $0 per share. | N/A | | 14-Nov-08 | LEDDY PETER MICHAEL Officer | 949 | Direct | Disposition (Non Open Market) at $25.05 per share. | $23,772 | | 14-Nov-08 | HOFFMEISTER DAVID F Officer | 9,000 | Direct | Option Exercise at $0 per share. | N/A | | 14-Nov-08 | HOFFMEISTER DAVID F Officer | 3,218 | Direct | Disposition (Non Open Market) at $25.05 per share. | $80,610 | | 14-Nov-08 | LUCIER GREGORY T Officer | 12,000 | Indirect | Option Exercise at $0 per share. | N/A | | 14-Nov-08 | LUCIER GREGORY T Officer | 5,490 | Indirect | Disposition (Non Open Market) at $25.05 per share. | $137,524 | | 14-Nov-08 | LUCIER GREGORY T Officer | 37,800 | Indirect | Purchase at $26.42 per share. | $998,676 | | 14-Nov-08 | BARTHELEMY NICOLAS Officer | 5,000 | Direct | Option Exercise at $0 per share. | N/A | | 14-Nov-08 | COTTINGHAM JOHN A Officer | 3,000 | Direct | Option Exercise at $0 per share. | N/A | | 14-Nov-08 | COTTINGHAM JOHN A Officer | 1,073 | Direct | Disposition (Non Open Market) at $25.05 per share. | $26,878 | | 14-Nov-08 | BENCHIMOL CLAUDE Officer | 6,000 | Direct | Option Exercise at $0 per share. | N/A | | 14-Nov-08 | BENCHIMOL CLAUDE Officer | 2,145 | Direct | Disposition (Non Open Market) at $25.05 per share. | $53,732 | | 14-Nov-08 | MATRICARIA RONALD A Director | 10,000 | Direct | Purchase at $26.24 per share. | $262,400 | | 5-Jul-08 | LEDDY PETER MICHAEL Officer | 40,000 | Direct | Option Exercise at $0 per share. | N/A | | 5-Jul-08 | LEDDY PETER MICHAEL Officer | 16,233 | Direct | Disposition (Non Open Market) at $38.41 per share. | $623,509 | | 15-May-08 | BRUST BERND Officer | 200 | Direct | Option Exercise at $92.83 per share. | $18,566 | | 15-May-08 | BRUST BERND Officer | 7,000 | Direct | Option Exercise at $71.74 per share. | $502,179 | | 15-May-08 | BRUST BERND Officer | 2,075 | Direct | Sale at $92.86 - $93.04 per share. | $193,0002 | | 15-May-08 | BRUST BERND Officer | 4,725 | Direct | Sale at $92.34 - $92.83 per share. | $437,0002 | | 13-May-08 | BRUST BERND Officer | 500 | Direct | Option Exercise at $0 per share. | N/A | | 13-May-08 | BRUST BERND Officer | 179 | Direct | Disposition (Non Open Market) at $92.26 per share. | $16,514 | | 13-May-08 | HOFFMEISTER DAVID F Officer | 4,500 | Direct | Option Exercise at $0 per share. | N/A | | 13-May-08 | HOFFMEISTER DAVID F Officer | 1,609 | Direct | Disposition (Non Open Market) at $92.26 per share. | $148,446 | | 13-May-08 | LUCIER GREGORY T Officer | 6,000 | Indirect | Option Exercise at $0 per share. | N/A | | 13-May-08 | LUCIER GREGORY T Officer | 2,145 | Indirect | Disposition (Non Open Market) at $92.26 per share. | $197,897 | | 13-May-08 | BARTHELEMY NICOLAS Officer | 3,000 | Direct | Option Exercise at $0 per share. | N/A | | 13-May-08 | BARTHELEMY NICOLAS Officer | 1,073 | Direct | Disposition (Non Open Market) at $92.26 per share. | $98,994 | | 13-May-08 | COTTINGHAM JOHN A Officer | 1,500 | Direct | Option Exercise at $0 per share. | N/A | | 13-May-08 | COTTINGHAM JOHN A Officer | 537 | Direct | Disposition (Non Open Market) at $92.26 per share. | $49,543 | | 13-May-08 | BENCHIMOL CLAUDE Officer | 3,000 | Direct | Option Exercise at $0 per share. | N/A | | 13-May-08 | BENCHIMOL CLAUDE Officer | 1,073 | Direct | Disposition (Non Open Market) at $92.26 per share. | $98,994 | | 12-May-08 | BRUST BERND Officer | 3,750 | Direct | Option Exercise at $65.87 per share. | $247,012 | | 12-May-08 | BRUST BERND Officer | 3,750 | Direct | Sale at $92.79 - $93.27 per share. | $349,0002 | | 1-May-08 | SHORT JAY M PHD Director | 2,500 | Direct | Option Exercise at $12 - $30.08 per share. | N/A | | 1-May-08 | SHORT JAY M PHD Director | 2,500 | Direct | Sale at $94.44 - $94.75 per share. | $236,0002 | | 25-Apr-08 | GIBSON KAREN Officer | 6,383 | Direct | Option Exercise at $0 per share. | N/A | | 25-Apr-08 | GIBSON KAREN Officer | 6,950 | Direct | Sale at $91.01 - $91.25 per share. | $633,0002 | | 23-Apr-08 | BARTHELEMY NICOLAS Officer | 2,500 | Direct | Option Exercise at $0 per share. | N/A | | 23-Apr-08 | BARTHELEMY NICOLAS Officer | 2,500 | Direct | Sale at $93 per share. | $232,500 | | 27-Mar-08 | BARTHELEMY NICOLAS Officer | 2,500 | Direct | Option Exercise at $0 per share. | N/A | | 27-Mar-08 | BARTHELEMY NICOLAS Officer | 2,500 | Direct | Sale at $85.62 per share. | $214,050 | | 27-Feb-08 | GIBSON KAREN Officer | 14,250 | Direct | Option Exercise at $62.51 - $64.51 per share. | $905,0002 | | 27-Feb-08 | GIBSON KAREN Officer | 14,250 | Direct | Sale at $87 per share. | $1,239,750 | | 25-Feb-08 | GIBSON KAREN Officer | 1,221 | Direct | Sale at $85.20 per share. | $104,029 | | 19-Feb-08 | UPRICHARD DAVID C Director | 200 | Direct | Sale at $86.69 per share. | $17,338 | | 13-Feb-08 | UPRICHARD DAVID C Director | 300 | Direct | Sale at $86.34 per share. | $25,902 | | 8-Feb-08 | SHORT JAY M PHD Director | 27,846 | Direct | Option Exercise at $12 - $72.36 per share. | N/A | | 8-Feb-08 | SHORT JAY M PHD Director | 14,046 | Direct | Disposition (Non Open Market) at $0 per share. | N/A | | 8-Feb-08 | SHORT JAY M PHD Director | 13,800 | Direct | Sale at $88.12 per share. | $1,216,056 | | 2-Jan-08 | BRUST BERND Officer | 5,875 | Direct | Option Exercise at $56.59 per share. | $332,466 | | 2-Jan-08 | BRUST BERND Officer | 5,875 | Direct | Sale at $91.71 - $93.2 per share. | $543,0002 | | 17-Dec-07 | HOFFMEISTER DAVID F Officer | 27,909 | Direct | Sale at $94.78 - $94.98 per share. | $2,648,0002 | | 13-Dec-07 | UPRICHARD DAVID C Director | 2,100 | Direct | Option Exercise at $72.36 per share. | $151,956 | | 13-Dec-07 | UPRICHARD DAVID C Director | 2,100 | Direct | Sale at $94.67 - $94.69 per share. | $199,0002 | | 11-Dec-07 | LUCIER GREGORY T Officer | 65,676 | Indirect | Option Exercise at $38.01 per share. | $2,496,344 | | 11-Dec-07 | LUCIER GREGORY T Officer | 13,089 | Indirect | Sale at $95.10 - $95.89 per share. | $1,250,0002 | | 11-Dec-07 | LUCIER GREGORY T Officer | 15,647 | Indirect | Sale at $94.56 - $95.07 per share. | $1,484,0002 | | 11-Dec-07 | LUCIER GREGORY T Officer | 18,240 | Indirect | Sale at $94.19 - $94.55 per share. | $1,721,0002 | | 11-Dec-07 | LUCIER GREGORY T Officer | 18,700 | Indirect | Sale at $93.45 - $94.18 per share. | $1,754,0002 | | 11-Dec-07 | BENCHIMOL CLAUDE Officer | 6,804 | Direct | Option Exercise at $58.76 per share. | $399,803 | | 10-Dec-07 | LUCIER GREGORY T Officer | 105,648 | Indirect | Option Exercise at $38.01 per share. | $4,015,680 | | 10-Dec-07 | LUCIER GREGORY T Officer | 13,540 | Indirect | Sale at $98.72 - $99.15 per share. | $1,340,0002 | | 10-Dec-07 | LUCIER GREGORY T Officer | 22,360 | Indirect | Sale at $98.26 - $98.71 per share. | $2,202,0002 | | 10-Dec-07 | LUCIER GREGORY T Officer | 35,100 | Indirect | Sale at $97.83 - $98.23 per share. | $3,441,0002 | | 10-Dec-07 | LUCIER GREGORY T Officer | 12,048 | Indirect | Sale at $97.31 - $97.8 per share. | $1,175,0002 | | 10-Dec-07 | LUCIER GREGORY T Officer | 13,500 | Indirect | Sale at $96.77 - $97.3 per share. | $1,310,0002 | | 10-Dec-07 | LUCIER GREGORY T Officer | 8,900 | Indirect | Sale at $96.30 - $96.76 per share. | $859,0002 | | 7-Dec-07 | BRUST BERND Officer | 14,063 | Direct | Option Exercise at $76.24 per share. | $1,072,163 | | 7-Dec-07 | BRUST BERND Officer | 14,063 | Direct | Sale at $98.03 - $98.24 per share. | $1,380,0002 | | 6-Dec-07 | BENCHIMOL CLAUDE Officer | 93,196 | Direct | Option Exercise at $58.76 per share. | $5,476,196 | | 6-Dec-07 | BENCHIMOL CLAUDE Officer | 108,186 | Direct | Sale at $97.40 - $97.5 per share. | $10,543,0002 | | 5-Dec-07 | BENCHIMOL CLAUDE Officer | 500 | Direct | Disposition (Non Open Market) at $92.62 per share. | $46,310 | | 5-Dec-07 | COTTINGHAM JOHN A Officer | 15,000 | Direct | Option Exercise at $45.64 - $45.64 per share. | $685,0002 | | 5-Dec-07 | COTTINGHAM JOHN A Officer | 15,000 | Direct | Sale at $96.37 per share. | $1,445,550 | | 30-Nov-07 | BRUST BERND Officer | 5,625 | Direct | Option Exercise at $55.02 - $76.86 per share. | N/A | | 30-Nov-07 | BRUST BERND Officer | 5,625 | Direct | Sale at $96.09 - $97 per share. | $543,0002 |
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* = Where indicated, some values are estimates. 1 = Potential proceeds estimated by the filer. 2 = Estimated based on the average of multiple prices reported. 3 = Multiple dates reported. Most recent date shown. |
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