| INSIDER TRANSACTIONS REPORTED - LAST TWO YEARS |
| Date | Insider | Shares | Type | Transaction | Value* | | 6-Aug-09 | ESSEX WOODLANDS HEALTH VENTURES FUND VII LP Beneficial Owner (10% or more) | 437,593 | Direct | Sale at $0.18 per share. | $78,766 | | 6-Aug-09 | ESSEX WOODLANDS HEALTH VENTURES FUND VI L P Beneficial Owner (10% or more) | 368,872 | Direct | Sale at $0.18 per share. | $66,396 | | 6-Aug-09 | SLOAN GAIL A Officer | 1,810 | Direct | Sale at $0.19 per share. | $343 | | 6-Aug-09 | SUTTER MARTIN P Director | 824,465 | Indirect | Sale at $0.18 per share. | $148,403 | | 5-Aug-09 | ESSEX WOODLANDS HEALTH VENTURES FUND VII LP Beneficial Owner (10% or more) | 623,026 | Direct | Sale at $0.19 per share. | $118,374 | | 5-Aug-09 | ESSEX WOODLANDS HEALTH VENTURES FUND VI L P Beneficial Owner (10% or more) | 792,942 | Direct | Sale at $0.19 per share. | $150,658 | | 5-Aug-09 | SUTTER MARTIN P Director | 1,415,968 | Indirect | Sale at $0.19 per share. | $269,033 | | 29-Jul-09 | SUTTER MARTIN P Director | 112,880 | Direct | Sale at $0.18 - $0.19 per share. | $21,0002 | | 25-Jun-09 | SLOAN GAIL A Officer | 2,230 | Indirect | Sale at $0.18 per share. | $401 | | 19-Jun-09 | BIOMARIN PHARMACEUTICAL INC Beneficial Owner (10% or more) | 2,546,958 | Direct | Sale at $0.21 per share. | $534,861 | | 18-Jun-09 | SLOAN GAIL A Officer | 4,914 | Direct | Sale at $0.20 per share. | $982 | | 18-Jun-09 | BIOMARIN PHARMACEUTICAL INC Beneficial Owner (10% or more) | 2,198,825 | Direct | Sale at $0.21 per share. | $461,753 | | 17-Jun-09 | BIOMARIN PHARMACEUTICAL INC Beneficial Owner (10% or more) | 960,950 | Direct | Sale at $0.22 per share. | $211,409 | | 27-Mar-09 | BIOMARIN PHARMACEUTICAL INC Beneficial Owner (10% or more) | 10,173,120 | Direct | Acquisition (Non Open Market) | N/A | | 26-Feb-09 | FILDES ROBERT PHD Director | 16,612 | Direct | Sale at $0.05 per share. | $830 | | 26-Feb-09 | SMITH CRAIG R Director | 27,200 | Direct | Sale at $0.06 per share. | $1,632 | | 26-Feb-09 | ESSEX WOODLANDS HEALTH VENTURES FUND VII LP Beneficial Owner (10% or more) | 3,328,747 | Direct | Sale at $0.05 per share. | $166,437 | | 26-Feb-09 | TOPPER JAMES N Director | 2,756,711 | Indirect | Sale at $0.06 per share. | $165,402 | | 26-Feb-09 | ESSEX WOODLANDS HEALTH VENTURES FUND VI L P Beneficial Owner (10% or more) | 4,236,586 | Direct | Sale at $0.05 per share. | $211,829 | | 25-Feb-09 | ESSEX WOODLANDS HEALTH VENTURES FUND VII LP Beneficial Owner (10% or more) | 1,717,737 | Direct | Sale at $0.06 per share. | $103,064 | | 25-Feb-09 | TOPPER JAMES N Director | 1,454,000 | Indirect | Sale at $0.06 per share. | $87,240 | | 25-Feb-09 | ESSEX WOODLANDS HEALTH VENTURES FUND VI L P Beneficial Owner (10% or more) | 2,186,211 | Direct | Sale at $0.06 per share. | $131,172 | | 24-Feb-09 | ELCHICO JOSEFINA T Officer | 25,759 | Direct | Sale at $0.10 per share. | $2,575 | | 24-Feb-09 | ESSEX WOODLANDS HEALTH VENTURES FUND VII LP Beneficial Owner (10% or more) | 1,700,312 | Direct | Sale at $0.07 per share. | $119,021 | | 24-Feb-09 | TOPPER JAMES N Director | 1,662,000 | Indirect | Sale at $0.07 per share. | $116,340 | | 24-Feb-09 | ESSEX WOODLANDS HEALTH VENTURES FUND VI L P Beneficial Owner (10% or more) | 2,164,033 | Direct | Sale at $0.07 per share. | $151,482 | | 24-Feb-09 | FRAZIER HEALTHCARE V, LP Beneficial Owner (10% or more) | 1,662,000 | Direct | Sale at $0.07 per share. | $116,340 | | 12-Feb-09 | GONZALEZ ALEJANDRO Beneficial Owner (10% or more) | 8,205,692 | Direct | Sale at $0.20 per share. | $1,641,138 | | 23-Jan-09 | SUTTER MARTIN P Director | 31,091 | Direct | Purchase at $1.46 - $1.5 per share. | $46,0002 | | 22-Jan-09 | SUTTER MARTIN P Director | 68,909 | Direct | Purchase at $1.33 - $1.4 per share. | $94,0002 | | 12-May-08 | ESSEX WOODLANDS HEALTH VENTURES FUND VII LP Beneficial Owner (10% or more) | 7,807,415 | Direct | Purchase at $1.89 per share. | $14,756,014 | | 12-May-08 | GONZALEZ ALEJANDRO Beneficial Owner (10% or more) | 1,619,256 | Direct | Purchase at $1.89 per share. | $3,060,393 | | 12-May-08 | ESSEX WOODLANDS HEALTH VENTURES FUND VI L P Beneficial Owner (10% or more) | 2,081,977 | Direct | Purchase at $1.89 per share. | $3,934,936 | | 12-May-08 | SUTTER MARTIN P Director | 7,807,415 | Indirect | Purchase at $1.89 per share. | $14,756,014 | | 12-May-08 | SUTTER MARTIN P Director | 2,081,977 | Indirect | Purchase at $1.89 per share. | $3,934,936 | | 12-May-08 | FRAZIER HEALTHCARE V, LP Beneficial Owner (10% or more) | 1,039,378 | Direct | Purchase at $1.89 per share. | $1,964,424 | | 10-Mar-08 | GONZALEZ ALEJANDRO Beneficial Owner (10% or more) | 551,100 | Direct | Purchase at $2.12 per share. | $1,168,332 | | 20-Dec-07 | ELCHICO JOSEFINA T Officer | 400 | Direct | Sale at $3.90 per share. | $1,560 | | 18-Dec-07 | GONZALEZ ALEJANDRO Beneficial Owner (10% or more) | 50,000 | Direct | Purchase at $3.93 per share. | $196,500 | | 14-Dec-07 | GONZALEZ ALEJANDRO Beneficial Owner (10% or more) | 57,508 | Direct | Purchase at $3.65 per share. | $209,904 |
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* = Where indicated, some values are estimates. 1 = Potential proceeds estimated by the filer. 2 = Estimated based on the average of multiple prices reported. 3 = Multiple dates reported. Most recent date shown. |
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