| INSIDER TRANSACTIONS REPORTED - LAST TWO YEARS |
| Date | Insider | Shares | Type | Transaction | Value* | | 2-Mar-09 | NGUYEN TRAN Officer | N/A | Direct | Statement of Ownership | N/A | | 19-Nov-08 | LAIKIND PAUL K Officer | 4,700 | Direct | Purchase at $0.49 - $0.75 per share. | N/A | | 18-Nov-08 | LAIKIND PAUL K Officer | 1,300 | Direct | Purchase at $0.49 - $0.59 per share. | $7022 | | 12-Nov-08 | GUMBINER BARRY Officer | 6,891 | Direct | Statement of Ownership | N/A | | 9-May-08 | MILLICAN TRISHA Officer | 1,151 | Direct | Statement of Ownership | N/A | | 23-Apr-08 | STONER ELIZABETH Director | N/A | Direct | Statement of Ownership | N/A | | 16-Apr-08 | MPM BIOVENTURES II QP LP Beneficial Owner (10% or more) | 244,881 | Indirect | Option Exercise at $2.34 per share. | $573,021 | | 16-Apr-08 | MPM BIOVENTURES II QP LP Beneficial Owner (10% or more) | 71,866 | Indirect | Purchase at $2.34 per share. | $168,166 | | 16-Apr-08 | ORONSKY ARNOLD L Director | 273,763 | Indirect | Option Exercise at $2.34 per share. | $640,605 | | 16-Apr-08 | ORONSKY ARNOLD L Director | 990,816 | Indirect | Purchase at $2.34 per share. | $2,318,509 | | 16-Apr-08 | EVNIN LUKE Director | 244,881 | Indirect | Option Exercise at $2.34 per share. | $573,021 | | 16-Apr-08 | EVNIN LUKE Director | 71,866 | Indirect | Purchase at $2.34 per share. | $168,166 | | 16-Apr-08 | INTERWEST PARTNERS VII L P Beneficial Owner (10% or more) | 12,511 | Indirect | Option Exercise at $2.34 per share. | $29,275 | | 16-Apr-08 | INTERWEST PARTNERS VII L P Beneficial Owner (10% or more) | 261,252 | Direct | Option Exercise at $2.34 per share. | $611,329 | | 16-Apr-08 | INTERWEST PARTNERS VII L P Beneficial Owner (10% or more) | 45,239 | Indirect | Purchase at $2.34 per share. | $105,859 | | 16-Apr-08 | INTERWEST PARTNERS VII L P Beneficial Owner (10% or more) | 945,577 | Direct | Purchase at $2.34 per share. | $2,212,650 | | 16-Apr-08 | HALE DAVID F Director | 3,111 | Indirect | Option Exercise at $2.34 per share. | $7,279 | | 16-Apr-08 | HALE DAVID F Director | 10,000 | Indirect | Purchase at $2.34 per share. | $23,400 | | 16-Apr-08 | CREDIT SUISSE AG/ Beneficial Owner (10% or more) | 196,633 | Indirect | Purchase at $2.34 per share. | $460,121 |
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* = Where indicated, some values are estimates. 1 = Potential proceeds estimated by the filer. 2 = Estimated based on the average of multiple prices reported. 3 = Multiple dates reported. Most recent date shown. |
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