| INSIDER TRANSACTIONS REPORTED - LAST TWO YEARS |
| Date | Insider | Shares | Type | Transaction | Value* | | 18-Nov-09 | HENSON MICHAEL R Director | 4,707 | Indirect | Sale at $13.46 - $13.68 per share. | $64,0002 | | 17-Nov-09 | HENSON MICHAEL R Director | 4,197 | Indirect | Sale at $13.40 - $13.55 per share. | $57,0002 | | 16-Nov-09 | HENSON MICHAEL R Director | 5,989 | Indirect | Sale at $13.32 - $13.66 per share. | $81,0002 | | 13-Nov-09 | ROBBINS JIM B Officer | 1,111 | Direct | Sale at $13.50 per share. | $14,998 | | 9-Nov-09 | HOPKINS LEO NELSON Director | 1,500 | Indirect | Sale at $12.99 - $13 per share. | $19,0002 | | 27-Aug-09 | HENSON MICHAEL R Director | 1,600 | Indirect | Sale at $12.01 - $12.04 per share. | $19,0002 | | 26-Aug-09 | HENSON MICHAEL R Director | 12,323 | Indirect | Sale at $11.93 - $12.05 per share. | $148,0002 | | 26-Aug-09 | HENSON MICHAEL R Director | 600 | Indirect | Sale at $11.92 per share. | $7,152 | | 25-Aug-09 | HENSON MICHAEL R Director | 17,500 | Indirect | Sale at $11.73 - $12.01 per share. | $208,0002 | | 13-Aug-09 | HBM BIOVENTURES CAYMAN LTD Beneficial Owner (10% or more) | 25,000 | Direct | Sale at $11 - $11.1 per share. | $276,0002 | | 12-Aug-09 | HBM BIOVENTURES CAYMAN LTD Beneficial Owner (10% or more) | 50,000 | Direct | Sale at $11 - $11.21 per share. | $555,0002 | | 11-Aug-09 | HBM BIOVENTURES CAYMAN LTD Beneficial Owner (10% or more) | 43,900 | Direct | Sale at $10.88 - $11.06 per share. | $482,0002 | | 10-Aug-09 | HBM BIOVENTURES CAYMAN LTD Beneficial Owner (10% or more) | 2,200 | Direct | Sale at $11.18 - $11.26 per share. | $25,0002 | | 10-Aug-09 | HBM BIOVENTURES CAYMAN LTD Beneficial Owner (10% or more) | 21,100 | Direct | Sale at $11 - $11.18 per share. | $234,0002 | | 7-Aug-09 | HBM BIOVENTURES CAYMAN LTD Beneficial Owner (10% or more) | 25,000 | Direct | Sale at $10.80 - $11.1 per share. | $274,0002 | | 30-Jun-09 | ROBBINS JIM B Officer | 3,333 | Direct | Option Exercise | N/A | | 30-Jun-09 | ROBBINS JIM B Officer | 1,191 | Direct | Disposition (Non Open Market) at $9.04 per share. | $10,766 | | 7-Jun-09 | ROBBINS JIM B Officer | 25 | Direct | Acquisition (Non Open Market) at $8.88 per share. | $222 | | 26-Feb-09 | HENSON MICHAEL R Director | 8,047 | Indirect | Purchase at $5.90 - $6.1 per share. | $48,0002 | | 25-Feb-09 | HENSON MICHAEL R Director | 3,300 | Indirect | Purchase at $6.21 - $6.4 per share. | $21,0002 | | 24-Feb-09 | HENSON MICHAEL R Director | 2,000 | Indirect | Purchase at $6.64 - $6.66 per share. | $13,0002 | | 23-Feb-09 | HENSON MICHAEL R Director | 2,128 | Indirect | Purchase at $6.29 - $6.35 per share. | $13,0002 | | 19-Feb-09 | HENSON MICHAEL R Director | 5,022 | Indirect | Purchase at $6.83 - $7 per share. | $35,0002 | | 17-Feb-09 | HENSON MICHAEL R Director | 3,272 | Indirect | Purchase at $7.08 - $7.18 per share. | $23,0002 | | 11-Feb-09 | HENSON MICHAEL R Director | 5,000 | Indirect | Purchase at $7.38 - $7.48 per share. | $37,0002 | | 10-Feb-09 | HENSON MICHAEL R Director | 2,000 | Indirect | Purchase at $7.73 per share. | $15,460 | | 9-Feb-09 | HENSON MICHAEL R Director | 4,000 | Indirect | Purchase at $7.94 - $7.99 per share. | $32,0002 | | 9-Feb-09 | HOPKINS LEO NELSON Director | 1,500 | Indirect | Purchase at $8.22 per share. | $12,330 | | 12-Jan-09 | STERN ROBERT A Officer | 25 | Direct | Acquisition (Non Open Market) at $0.01 per share. | $N/A | | 21-Nov-08 | HENSON MICHAEL R Director | 2,000 | Indirect | Purchase at $9.04 per share. | $18,080 | | 20-Nov-08 | HENSON MICHAEL R Director | 14,100 | Indirect | Purchase at $9.70 - $9.73 per share. | $137,0002 | | 30-Jun-08 | ROBBINS JIM B Officer | 3,333 | Direct | Option Exercise | N/A | | 30-Jun-08 | ROBBINS JIM B Officer | 1,191 | Direct | Disposition (Non Open Market) at $14.02 per share. | $16,697 | | 20-Jun-08 | HBM BIOVENTURES CAYMAN LTD Beneficial Owner (10% or more) | 17,741 | Direct | Purchase at $13.61 - $13.9 per share. | $244,0002 | | 19-Jun-08 | HBM BIOVENTURES CAYMAN LTD Beneficial Owner (10% or more) | 3,459 | Direct | Purchase at $13.55 - $13.6 per share. | $47,0002 | | 17-Jun-08 | HBM BIOVENTURES CAYMAN LTD Beneficial Owner (10% or more) | 3,800 | Direct | Purchase at $13.49 - $13.6 per share. | $51,0002 | | 6-Jun-08 | HBM BIOVENTURES CAYMAN LTD Beneficial Owner (10% or more) | 15,000 | Direct | Purchase at $12.24 - $12.25 per share. | $184,0002 | | 5-Jun-08 | HBM BIOVENTURES CAYMAN LTD Beneficial Owner (10% or more) | 30,000 | Direct | Purchase at $12 - $12.6 per share. | $369,0002 | | 3-Jun-08 | RUPPEL EDWARD F JR Officer | 25 | Direct | Acquisition (Non Open Market) at $0.01 per share. | $N/A | | 28-May-08 | HENSON MICHAEL R Director | 1,000 | Indirect | Purchase at $10.73 per share. | $10,730 | | 23-May-08 | HENSON MICHAEL R Director | 1,000 | Indirect | Purchase at $10.53 per share. | $10,530 | | 20-May-08 | HENSON MICHAEL R Director | 1,000 | Indirect | Purchase at $10.73 per share. | $10,730 | | 19-May-08 | HENSON MICHAEL R Director | 3,000 | Indirect | Purchase at $10.83 - $10.93 per share. | $33,0002 | | 16-May-08 | HENSON MICHAEL R Director | 3,000 | Indirect | Purchase at $10.96 - $11.03 per share. | $33,0002 | | 15-May-08 | HENSON MICHAEL R Director | 1,000 | Indirect | Purchase at $11.30 per share. | $11,300 | | 14-May-08 | HENSON MICHAEL R Director | 1,000 | Indirect | Purchase at $11.33 per share. | $11,330 | | 29-Feb-08 | HENSON MICHAEL R Director | 2,000 | Indirect | Purchase at $14.04 - $14.19 per share. | $28,0002 | | 28-Feb-08 | HENSON MICHAEL R Director | 1,500 | Indirect | Purchase at $14.11 - $14.27 per share. | $21,0002 | | 15-Feb-08 | RUPPEL EDWARD F JR Officer | 3,555 | Direct | Option Exercise at $0.77 per share. | $2,737 | | 15-Feb-08 | RUPPEL EDWARD F JR Officer | 3,555 | Direct | Sale at $13.98 per share. | $49,698 | | 15-Feb-08 | HBM BIOVENTURES CAYMAN LTD Beneficial Owner (10% or more) | 7,700 | Direct | Purchase at $13.82 - $14 per share. | $107,0002 | | 14-Feb-08 | HBM BIOVENTURES CAYMAN LTD Beneficial Owner (10% or more) | 22,800 | Direct | Purchase at $14.22 - $14.41 per share. | $326,0002 | | 14-Feb-08 | HBM BIOVENTURES CAYMAN LTD Beneficial Owner (10% or more) | 23,600 | Direct | Purchase at $14.05 - $14.21 per share. | $333,0002 | | 13-Feb-08 | HBM BIOVENTURES CAYMAN LTD Beneficial Owner (10% or more) | 2,200 | Direct | Purchase at $14.67 - $14.93 per share. | $33,0002 | | 13-Feb-08 | HBM BIOVENTURES CAYMAN LTD Beneficial Owner (10% or more) | 50,100 | Direct | Purchase at $14.43 - $14.66 per share. | $729,0002 | | 13-Feb-08 | HBM BIOVENTURES CAYMAN LTD Beneficial Owner (10% or more) | 7,700 | Direct | Purchase at $14.37 - $14.42 per share. | $111,0002 | | 12-Feb-08 | HBM BIOVENTURES CAYMAN LTD Beneficial Owner (10% or more) | 29,900 | Direct | Purchase at $14.41 - $14.7 per share. | $435,0002 | | 12-Feb-08 | HBM BIOVENTURES CAYMAN LTD Beneficial Owner (10% or more) | 32,500 | Direct | Purchase at $14.71 - $14.92 per share. | $481,0002 | | 3-Dec-07 | AURAN MITCH Officer | 18,800 | Direct | Acquisition (Non Open Market) at $0 per share. | N/A | | 3-Dec-07 | AURAN MITCH Officer | 156,666 | Indirect | Disposition (Non Open Market) at $0 per share. | N/A |
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* = Where indicated, some values are estimates. 1 = Potential proceeds estimated by the filer. 2 = Estimated based on the average of multiple prices reported. 3 = Multiple dates reported. Most recent date shown. |
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