| Date | Insider | Shares | Type | Transaction | Value* |
| 5-Nov-09 | MITCHELL W THOMAS Director | 900 | Indirect | Purchase at $2.17 per share. | $1,953 |
| 28-Sep-09 | GRIGORIADIS DIMITRI E. Officer | 3,038 | Direct | Automatic Sale at $3.12 per share. | $9,478 |
| 28-Sep-09 | OBRIEN CHRISTOPHER FLINT Officer | 4,859 | Direct | Automatic Sale at $3.11 per share. | $15,111 |
| 28-Sep-09 | BOZIGIAN HAIG P. Officer | 3,642 | Direct | Automatic Sale at $3.11 per share. | $11,326 |
| 30-Mar-09 | BOZIGIAN HAIG P. Officer | 12,774 | Direct | Automatic Sale at $3.43 per share. | $43,814 |
| 30-Mar-09 | GRIGORIADIS DIMITRI E. Officer | 12,606 | Direct | Automatic Sale at $3.43 per share. | $43,238 |
| 30-Mar-09 | COUGHLIN TIMOTHY P Officer | 12,117 | Direct | Automatic Sale at $3.43 per share. | $41,561 |
| 30-Mar-09 | OBRIEN CHRISTOPHER FLINT Officer | 12,151 | Direct | Automatic Sale at $3.43 per share. | $41,677 |
| 30-Mar-09 | VALEUR JENSEN MARGARET E Officer | 12,117 | Direct | Automatic Sale at $3.43 per share. | $41,561 |
| 30-Mar-09 | GORMAN KEVIN CHARLES Officer | 15,146 | Direct | Automatic Sale at $3.43 per share. | $51,950 |
| 23-Jan-09 | BVF PARTNERS L P/IL Beneficial Owner (10% or more) | 9,000 | Indirect | Purchase at $3.10 per share. | $27,900 |
| 22-Jan-09 | BVF PARTNERS L P/IL Beneficial Owner (10% or more) | 6,900 | Indirect | Purchase at $3.10 per share. | $21,390 |
| 21-Jan-09 | BVF PARTNERS L P/IL Beneficial Owner (10% or more) | 25,200 | Indirect | Purchase at $3.06 per share. | $77,112 |
| 20-Jan-09 | BVF PARTNERS L P/IL Beneficial Owner (10% or more) | 75,000 | Indirect | Purchase at $3.08 per share. | $231,000 |
| 15-Jan-09 | BVF PARTNERS L P/IL Beneficial Owner (10% or more) | 7,400 | Indirect | Purchase at $3.05 per share. | $22,570 |
| 13-Jan-09 | COUGHLIN TIMOTHY P Officer | 8,463 | Direct | Automatic Sale at $3.39 per share. | $28,689 |
| 13-Jan-09 | GORMAN KEVIN CHARLES Officer | 9,195 | Direct | Automatic Sale at $3.37 per share. | $30,987 |
| 12-Jan-09 | VALEUR JENSEN MARGARET E Officer | 8,463 | Direct | Automatic Sale at $3.25 per share. | $27,504 |
| 5-Jan-09 | BOZIGIAN HAIG P. Officer | 733 | Direct | Automatic Sale at $3.40 per share. | $2,492 |
| 5-Jan-09 | GRIGORIADIS DIMITRI E. Officer | 1,462 | Direct | Automatic Sale at $3.40 per share. | $4,970 |
| 5-Jan-09 | OBRIEN CHRISTOPHER FLINT Officer | 1,462 | Direct | Automatic Sale at $3.41 per share. | $4,985 |
| 30-Dec-08 | BVF PARTNERS L P/IL Beneficial Owner (10% or more) | 10,600 | Indirect | Purchase at $2.80 per share. | $29,679 |
| 1-Dec-08 | BVF PARTNERS L P/IL Beneficial Owner (10% or more) | 99,400 | Indirect | Purchase at $2.35 per share. | $233,590 |
| 24-Nov-08 | BVF PARTNERS L P/IL Beneficial Owner (10% or more) | 54,400 | Indirect | Purchase at $2.45 per share. | $133,280 |
| 10-Oct-08 | BVF PARTNERS L P/IL Beneficial Owner (10% or more) | 447,047 | Indirect | Purchase at $2.72 per share. | $1,215,967 |
| 29-Sep-08 | BOZIGIAN HAIG P. Officer | 3,618 | Direct | Automatic Sale at $4.70 per share. | $17,004 |
| 29-Sep-08 | GRIGORIADIS DIMITRI E. Officer | 3,017 | Direct | Automatic Sale at $4.71 per share. | $14,210 |
| 29-Sep-08 | OBRIEN CHRISTOPHER FLINT Officer | 4,824 | Direct | Automatic Sale at $4.69 per share. | $22,624 |
| 8-Jul-08 | BVF PARTNERS L P/IL Beneficial Owner (10% or more) | 3,400 | Indirect | Purchase at $4.25 per share. | $14,450 |
| 7-Jul-08 | BVF PARTNERS L P/IL Beneficial Owner (10% or more) | 115,700 | Indirect | Purchase at $4.24 per share. | $490,568 |
| 3-Jul-08 | BVF PARTNERS L P/IL Beneficial Owner (10% or more) | 11,100 | Indirect | Purchase at $4.15 per share. | $46,065 |
| 2-Jul-08 | BVF PARTNERS L P/IL Beneficial Owner (10% or more) | 26,600 | Indirect | Purchase at $4.18 per share. | $111,187 |
| 28-May-08 | BVF PARTNERS L P/IL Beneficial Owner (10% or more) | 22,100 | Indirect | Purchase at $4.72 per share. | $104,312 |
| 27-May-08 | BVF PARTNERS L P/IL Beneficial Owner (10% or more) | 5,000 | Indirect | Purchase at $4.71 per share. | $23,550 |
| 16-May-08 | BVF PARTNERS L P/IL Beneficial Owner (10% or more) | 26,300 | Indirect | Purchase at $4.65 per share. | $122,295 |
| 15-May-08 | BVF PARTNERS L P/IL Beneficial Owner (10% or more) | 126,300 | Indirect | Purchase at $4.63 per share. | $584,769 |
| 13-May-08 | GRIGORIADIS DIMITRI E. Officer | 6,485 | Direct | Sale at $5.05 per share. | $32,749 |
| 20-Mar-08 | BVF PARTNERS L P/IL Beneficial Owner (10% or more) | 43,600 | Indirect | Purchase at $5 per share. | $218,000 |
| 18-Mar-08 | BVF PARTNERS L P/IL Beneficial Owner (10% or more) | 153,000 | Indirect | Purchase at $4.96 per share. | $758,880 |
| 13-Mar-08 | BVF PARTNERS L P/IL Beneficial Owner (10% or more) | 23,900 | Indirect | Purchase at $4.92 per share. | $117,588 |
| 12-Mar-08 | BVF PARTNERS L P/IL Beneficial Owner (10% or more) | 14,800 | Indirect | Purchase at $5 per share. | $74,000 |
| 11-Mar-08 | BVF PARTNERS L P/IL Beneficial Owner (10% or more) | 141,800 | Indirect | Purchase at $4.90 per share. | $694,820 |
| 10-Mar-08 | BVF PARTNERS L P/IL Beneficial Owner (10% or more) | 225,000 | Indirect | Purchase at $4.89 per share. | $1,100,250 |
| 7-Mar-08 | BVF PARTNERS L P/IL Beneficial Owner (10% or more) | 104,600 | Indirect | Purchase at $4.99 per share. | $521,954 |
| 6-Mar-08 | BVF PARTNERS L P/IL Beneficial Owner (10% or more) | 86,700 | Indirect | Purchase at $5 per share. | $433,500 |
| 4-Mar-08 | BVF PARTNERS L P/IL Beneficial Owner (10% or more) | 23,200 | Indirect | Purchase at $4.97 per share. | $115,304 |
| 3-Mar-08 | BVF PARTNERS L P/IL Beneficial Owner (10% or more) | 98,000 | Indirect | Purchase at $4.93 per share. | $483,140 |
| 29-Feb-08 | BVF PARTNERS L P/IL Beneficial Owner (10% or more) | 47,400 | Indirect | Purchase at $4.99 per share. | $236,526 |
| 28-Feb-08 | BVF PARTNERS L P/IL Beneficial Owner (10% or more) | 23,000 | Indirect | Purchase at $5 per share. | $115,000 |
| 26-Feb-08 | BVF PARTNERS L P/IL Beneficial Owner (10% or more) | 20,800 | Indirect | Purchase at $5 per share. | $104,000 |
| 25-Feb-08 | BVF PARTNERS L P/IL Beneficial Owner (10% or more) | 108,000 | Indirect | Purchase at $4.96 per share. | $535,680 |
| 22-Feb-08 | BVF PARTNERS L P/IL Beneficial Owner (10% or more) | 79,000 | Indirect | Purchase at $4.84 per share. | $382,360 |
| 21-Feb-08 | BVF PARTNERS L P/IL Beneficial Owner (10% or more) | 106,000 | Indirect | Purchase at $4.70 per share. | $498,200 |
| 20-Feb-08 | BVF PARTNERS L P/IL Beneficial Owner (10% or more) | 3,576,300 | Indirect | Statement of Ownership | N/A |
| 20-Feb-08 | BVF PARTNERS L P/IL Beneficial Owner (10% or more) | 2,101,000 | Direct | Statement of Ownership | N/A |
| 12-Feb-08 | COUGHLIN TIMOTHY P Officer | 200 | Direct | Automatic Sale at $5.17 per share. | $1,034 |
| 12-Feb-08 | COUGHLIN TIMOTHY P Officer | 7,657 | Direct | Sale at $4.96 - $5.1 per share. | $39,0002 |
| 12-Feb-08 | RANIERI RICHARD J Officer | 300 | Direct | Automatic Sale at $5.17 per share. | $1,551 |
| 12-Feb-08 | RANIERI RICHARD J Officer | 9,366 | Direct | Sale at $4.96 - $5.1 per share. | $47,0002 |
| 12-Feb-08 | VALEUR JENSEN MARGARET E Officer | 300 | Direct | Automatic Sale at $5.17 per share. | $1,551 |
| 12-Feb-08 | VALEUR JENSEN MARGARET E Officer | 7,363 | Direct | Sale at $4.96 - $5.1 per share. | $37,0002 |
| 12-Feb-08 | GORMAN KEVIN CHARLES Officer | 400 | Direct | Automatic Sale at $5.10 per share. | $2,039 |
| 12-Feb-08 | GORMAN KEVIN CHARLES Officer | 7,830 | Direct | Sale at $4.96 - $5.09 per share. | $39,0002 |
| 5-Feb-08 | BOZIGIAN HAIG P. Officer | 722 | Direct | Automatic Sale at $5.31 per share. | $3,833 |
| 5-Feb-08 | GRIGORIADIS DIMITRI E. Officer | 1,206 | Direct | Automatic Sale at $5.31 per share. | $6,403 |
| 10-Jan-08 | BOZIGIAN HAIG P. Officer | 247 | Direct | Statement of Ownership | N/A |
| 10-Jan-08 | GRIGORIADIS DIMITRI E. Officer | 4,358 | Direct | Statement of Ownership | N/A |