| INSIDER TRANSACTIONS REPORTED - LAST TWO YEARS |
| Date | Insider | Shares | Type | Transaction | Value* | | 25-Jul-08 | SIMON JOHN Director | 249,990 | Direct | Acquisition (Non Open Market) | N/A | | 25-Jul-08 | BAKER BROTHERS LIFE SCIENCES CAPITAL (GP), LLC Director | 1,371,162 | Indirect | Acquisition (Non Open Market) | N/A | | 25-Jul-08 | BAKER / TISCH CAPITAL (GP), LLC Director | 125,112 | Indirect | Acquisition (Non Open Market) | N/A | | 25-Jul-08 | BAKER BROS. CAPITAL (GP), LLC Director | 257,504 | Indirect | Acquisition (Non Open Market) | N/A | | 25-Jul-08 | BAKER BIOTECH CAPITAL (GP), LLC Director | 1,304,550 | Indirect | Acquisition (Non Open Market) | N/A | | 25-Jul-08 | HEN STEWART Director | 4,999,982 | Indirect | Acquisition (Non Open Market) | N/A | | 25-Jul-08 | LEFF JONATHAN S Director | 4,999,982 | Indirect | Acquisition (Non Open Market) | N/A | | 25-Jul-08 | WARBURG PINCUS PRIVATE EQUITY VIII L P Director | 4,999,982 | Direct | Acquisition (Non Open Market) | N/A | | 17-Apr-08 | PITLER THOMAS A. Officer | 17,189 | Indirect | Statement of Ownership | N/A | | 14-Feb-08 | LAMATTINA JOHN L Director | N/A | Direct | Statement of Ownership | N/A |
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* = Where indicated, some values are estimates. 1 = Potential proceeds estimated by the filer. 2 = Estimated based on the average of multiple prices reported. 3 = Multiple dates reported. Most recent date shown. |
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