| INSIDER TRANSACTIONS REPORTED - LAST TWO YEARS |
| Date | Insider | Shares | Type | Transaction | Value* | | 27-Jan-09 | DOVEY BRIAN H Director | 2,869 | Direct | Option Exercise | N/A | | 27-Jan-09 | PARKER H STEWART Director | 2,869 | Direct | Option Exercise at $0 per share. | N/A | | 27-Jan-09 | HAMILTON WILLIAM F PHD Director | 5,738 | Direct | Option Exercise at $0 per share. | N/A | | 27-Jan-09 | MACMASTER JR DOUGLAS J Director | 8,197 | Direct | Option Exercise at $0 per share. | N/A | | 27-Jan-09 | GAGE L PATRICK Director | 8,197 | Direct | Option Exercise at $0 per share. | N/A | | 30-Sep-08 | TANG KEVIN C Beneficial Owner (10% or more) | 5,664 | Indirect | Purchase at $0.32 per share. | $1,812 | | 29-Sep-08 | TANG KEVIN C Beneficial Owner (10% or more) | 2,800 | Indirect | Purchase at $0.33 per share. | $924 | | 26-Sep-08 | TANG KEVIN C Beneficial Owner (10% or more) | 25,763 | Indirect | Purchase at $0.33 per share. | $8,501 | | 25-Sep-08 | TANG KEVIN C Beneficial Owner (10% or more) | 56,096 | Indirect | Purchase at $0.33 per share. | $18,511 | | 24-Sep-08 | TANG KEVIN C Beneficial Owner (10% or more) | 56,819 | Indirect | Purchase at $0.32 per share. | $18,182 | | 23-Sep-08 | TANG KEVIN C Beneficial Owner (10% or more) | 13,250 | Indirect | Purchase at $0.30 per share. | $3,975 | | 22-Sep-08 | BARCLAYS PLC Beneficial Owner (10% or more) | 5,657,407 | Indirect | Statement of Ownership | N/A | | 22-Sep-08 | TANG KEVIN C Beneficial Owner (10% or more) | 100,200 | Indirect | Purchase at $0.32 per share. | $32,064 | | 19-Sep-08 | TANG KEVIN C Beneficial Owner (10% or more) | 401,600 | Indirect | Purchase at $0.30 per share. | $120,480 | | 18-Sep-08 | TANG KEVIN C Beneficial Owner (10% or more) | 1,251,900 | Indirect | Purchase at $0.27 per share. | $338,013 | | 17-Sep-08 | TANG KEVIN C Beneficial Owner (10% or more) | 1,025,800 | Indirect | Purchase at $0.24 - $0.3 per share. | N/A | | 15-Sep-08 | TANG KEVIN C Beneficial Owner (10% or more) | 7,472,414 | Indirect | Disposition (Non Open Market) at $0 per share. | N/A | | 2-Jul-08 | TANG KEVIN C Beneficial Owner (10% or more) | 7,472,414 | Indirect | Statement of Ownership | N/A | | 4-Feb-08 | DEFREES SHAWN A Officer | 18,328 | Direct | Statement of Ownership | N/A | | 30-Jul-07 | DAVIS A BRIAN Officer | 4,695 | Direct | Disposition (Non Open Market) at $2 - $2 per share. | $9,3902 | | 30-Jul-07 | DAVIS A BRIAN Officer | 16,155 | Direct | Acquisition (Non Open Market) at $0 per share. | N/A | | 30-Jul-07 | POUL DEBRA J Officer | 4,695 | Direct | Disposition (Non Open Market) at $2 - $2 per share. | $9,3902 | | 30-Jul-07 | POUL DEBRA J Officer | 16,155 | Direct | Acquisition (Non Open Market) at $0 per share. | N/A | | 30-Jul-07 | ZOPF DAVID A MD Officer | 4,695 | Direct | Disposition (Non Open Market) at $2 - $2 per share. | $9,3902 | | 30-Jul-07 | ZOPF DAVID A MD Officer | 16,155 | Direct | Acquisition (Non Open Market) at $0 per share. | N/A | | 30-Jul-07 | VERGIS GEORGE J Officer | 4,695 | Direct | Disposition (Non Open Market) at $2 - $2 per share. | $9,3902 | | 30-Jul-07 | VERGIS GEORGE J Officer | 16,155 | Direct | Acquisition (Non Open Market) at $0 per share. | N/A | | 11-Jun-07 | GAGE L PATRICK Director | 10,550 | Direct | Purchase at $2.60 per share. | $27,430 | | 8-Jun-07 | GAGE L PATRICK Director | 15,050 | Direct | Purchase at $2.60 - $2.6 per share. | $39,0002 | | 7-Jun-07 | GAGE L PATRICK Director | 13,900 | Direct | Purchase at $2.59 - $2.59 per share. | $36,0002 | | 30-Mar-07 | RACHESKY MARK H MD Director | 430,564 | Indirect | Disposition (Non Open Market) | N/A | | 26-Mar-07 | GAGE L PATRICK Director | 15,000 | Direct | Purchase at $2 - $2.07 per share. | $31,0002 | | 13-Mar-07 | RACHESKY MARK H MD Director | 2,475,247 | Indirect | Purchase | N/A | | 9-Mar-07 | DOVEY BRIAN H Director | 2,475,248 | Indirect | Purchase | N/A |
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* = Where indicated, some values are estimates. 1 = Potential proceeds estimated by the filer. 2 = Estimated based on the average of multiple prices reported. 3 = Multiple dates reported. Most recent date shown. |
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