| Date | Insider | Shares | Type | Transaction | Value* |
| 24-Apr-09 | RHO INVESTMENT PARTNERS H LP Beneficial Owner (10% or more) | 4,974,674 | Indirect | Disposition (Non Open Market) at $0.86 per share. | $4,278,219 |
| 24-Apr-09 | RHO VENTURES IV QP LP Beneficial Owner (10% or more) | 4,974,674 | Indirect | Disposition (Non Open Market) at $0.86 per share. | $4,278,219 |
| 24-Apr-09 | INVUS PUBLIC EQUITIES ADVISORS, LLC Beneficial Owner (10% or more) | 4,989,024 | Direct | Disposition (Non Open Market) at $0.86 per share. | $4,290,560 |
| 24-Apr-09 | SARNEY KEVIN G Officer | 7,856 | Direct | Disposition (Non Open Market) | N/A |
| 24-Apr-09 | SOBECKI CHRISTOPHER J Director | 4,989,024 | Indirect | Disposition (Non Open Market) | N/A |
| 24-Apr-09 | FLYNN JAMES E Beneficial Owner (10% or more) | 46,085,133 | Indirect | Purchase at $0.86 per share. | $39,633,214 |
| 24-Apr-09 | FLYNN JAMES E Beneficial Owner (10% or more) | 5,064,516 | Indirect | Disposition (Non Open Market) at $0.86 per share. | $4,355,483 |
| 24-Apr-09 | LOSCALZO JOSEPH Director | 3,449 | Direct | Disposition (Non Open Market) | N/A |
| 24-Apr-09 | KARABELAS ARGERIS N Director | 1,332,856 | Indirect | Disposition (Non Open Market) | N/A |
| 24-Apr-09 | KARABELAS ARGERIS N Director | 11,179 | Direct | Disposition (Non Open Market) | N/A |
| 24-Apr-09 | COHEN ROBERT S Director | 17,500 | Direct | Disposition (Non Open Market) | N/A |
| 24-Apr-09 | LITTLECHILD JOHN W Director | 66,762 | Direct | Disposition (Non Open Market) at $0.86 per share. | $57,415 |
| 24-Apr-09 | LITTLECHILD JOHN W Director | 3,239,598 | Indirect | Disposition (Non Open Market) at $0.86 per share. | $2,786,054 |
| 24-Apr-09 | LESCHLY MARK Director | 4,848,258 | Indirect | Disposition (Non Open Market) | N/A |
| 24-Apr-09 | LESCHLY MARK Director | 23,744 | Direct | Disposition (Non Open Market) | N/A |
| 24-Apr-09 | HOROVITZ ZOLA P Director | 17,500 | Direct | Disposition (Non Open Market) | N/A |
| 1-Apr-09 | SARNEY KEVIN G Officer | 355 | Direct | Disposition (Non Open Market) at $0.75 per share. | $266 |
| 16-Mar-09 | SARNEY KEVIN G Officer | 2,263 | Direct | Disposition (Non Open Market) at $0.73 per share. | $1,651 |
| 16-Mar-09 | COHEN ROBERT S Director | 5,000 | Direct | Option Exercise at $0.72 per share. | $3,600 |
| 16-Mar-09 | HOROVITZ ZOLA P Director | 5,000 | Direct | Option Exercise at $0.72 per share. | $3,600 |
| 27-Jan-09 | DEERFIELD PRIVATE DESIGN FUND L P Beneficial Owner (10% or more) | N/A | Direct | Statement of Ownership | N/A |
| 23-Dec-08 | FLYNN JAMES E Beneficial Owner (10% or more) | 460,831 | Indirect | Sale at $0.52 - $0.56 per share. | $249,0002 |
| 4-Aug-08 | FLYNN JAMES E Beneficial Owner (10% or more) | 2,035 | Indirect | Purchase at $1.01 per share. | $2,055 |
| 31-Jul-08 | FLYNN JAMES E Beneficial Owner (10% or more) | 3,688 | Indirect | Purchase at $1.01 per share. | $3,724 |
| 30-Jul-08 | FLYNN JAMES E Beneficial Owner (10% or more) | 11,000 | Indirect | Purchase at $1.01 per share. | $11,110 |
| 29-Jul-08 | FLYNN JAMES E Beneficial Owner (10% or more) | 980 | Indirect | Purchase at $1.01 per share. | $989 |
| 29-Jul-08 | FLYNN JAMES E Beneficial Owner (10% or more) | 6,762 | Indirect | Purchase at $1.01 per share. | $6,829 |
| 28-Jul-08 | FLYNN JAMES E Beneficial Owner (10% or more) | 50,140 | Indirect | Purchase at $1 per share. | $50,140 |
| 25-Jul-08 | FLYNN JAMES E Beneficial Owner (10% or more) | 8,950 | Indirect | Purchase at $1.03 per share. | $9,218 |
| 24-Jul-08 | FLYNN JAMES E Beneficial Owner (10% or more) | 19,900 | Indirect | Purchase at $1 per share. | $19,900 |
| 23-Jul-08 | FLYNN JAMES E Beneficial Owner (10% or more) | 11,952 | Indirect | Purchase at $1.02 per share. | $12,191 |
| 21-Jul-08 | FLYNN JAMES E Beneficial Owner (10% or more) | 59,117 | Indirect | Purchase at $1.01 per share. | $59,708 |
| 18-Jul-08 | FLYNN JAMES E Beneficial Owner (10% or more) | 43,619 | Indirect | Purchase at $1.02 per share. | $44,491 |
| 16-Jul-08 | FLYNN JAMES E Beneficial Owner (10% or more) | 1,190 | Indirect | Purchase at $0.99 per share. | $1,178 |
| 15-Jul-08 | FLYNN JAMES E Beneficial Owner (10% or more) | 420 | Indirect | Purchase at $1.01 per share. | $424 |
| 14-Jul-08 | FLYNN JAMES E Beneficial Owner (10% or more) | 24,940 | Indirect | Purchase at $1.02 per share. | $25,438 |
| 11-Jul-08 | FLYNN JAMES E Beneficial Owner (10% or more) | 24,188 | Indirect | Purchase at $0.97 per share. | $23,462 |
| 10-Jul-08 | FLYNN JAMES E Beneficial Owner (10% or more) | 19,134 | Indirect | Purchase at $0.98 per share. | $18,751 |
| 9-Jul-08 | FLYNN JAMES E Beneficial Owner (10% or more) | 34,096 | Indirect | Purchase at $0.95 per share. | $32,391 |
| 8-Jul-08 | FLYNN JAMES E Beneficial Owner (10% or more) | 8,970 | Indirect | Purchase at $1 per share. | $8,970 |
| 7-Jul-08 | FLYNN JAMES E Beneficial Owner (10% or more) | 36,520 | Indirect | Purchase at $0.98 per share. | $35,789 |
| 1-Jul-08 | FLYNN JAMES E Beneficial Owner (10% or more) | 300 | Indirect | Purchase at $1.01 per share. | $303 |
| 30-Jun-08 | FLYNN JAMES E Beneficial Owner (10% or more) | 39,475 | Indirect | Purchase at $0.98 per share. | $38,685 |
| 27-Jun-08 | FLYNN JAMES E Beneficial Owner (10% or more) | 41,895 | Indirect | Purchase at $1.03 per share. | $43,151 |
| 26-Jun-08 | FLYNN JAMES E Beneficial Owner (10% or more) | 3,318 | Indirect | Purchase at $1.03 per share. | $3,417 |
| 19-May-08 | FLYNN JAMES E Beneficial Owner (10% or more) | 18,182 | Indirect | Purchase at $1.15 per share. | $20,909 |
| 16-May-08 | FLYNN JAMES E Beneficial Owner (10% or more) | 66,479 | Indirect | Purchase at $1.15 per share. | $76,450 |
| 15-May-08 | FLYNN JAMES E Beneficial Owner (10% or more) | 22,880 | Indirect | Purchase at $1.15 per share. | $26,311 |
| 14-May-08 | FLYNN JAMES E Beneficial Owner (10% or more) | 25,282 | Indirect | Purchase at $1.16 per share. | $29,327 |
| 13-May-08 | FLYNN JAMES E Beneficial Owner (10% or more) | 13,699 | Indirect | Purchase at $1.12 per share. | $15,342 |
| 12-May-08 | FLYNN JAMES E Beneficial Owner (10% or more) | 17,465 | Indirect | Purchase at $1.14 per share. | $19,910 |
| 9-May-08 | FLYNN JAMES E Beneficial Owner (10% or more) | 53,009 | Indirect | Purchase at $1.12 per share. | $59,370 |
| 8-May-08 | FLYNN JAMES E Beneficial Owner (10% or more) | 26,300 | Indirect | Purchase at $1.17 per share. | $30,770 |
| 7-May-08 | FLYNN JAMES E Beneficial Owner (10% or more) | 45,149 | Indirect | Purchase at $1.21 per share. | $54,630 |
| 6-May-08 | FLYNN JAMES E Beneficial Owner (10% or more) | 75,507 | Indirect | Purchase at $1.26 per share. | $95,138 |
| 5-May-08 | FLYNN JAMES E Beneficial Owner (10% or more) | 69,964 | Indirect | Purchase at $1.27 per share. | $88,854 |
| 2-May-08 | FLYNN JAMES E Beneficial Owner (10% or more) | 16,600 | Indirect | Purchase at $1.26 per share. | $20,916 |
| 1-May-08 | FLYNN JAMES E Beneficial Owner (10% or more) | 2,995,224 | Indirect | Statement of Ownership | N/A |
| 15-Apr-08 | KRAMER JANE Officer | 6,175 | Direct | Disposition (Non Open Market) at $1.22 per share. | $7,533 |
| 2-Apr-08 | SARNEY KEVIN G Officer | 265 | Direct | Automatic Sale at $1.07 per share. | $283 |
| 1-Apr-08 | SARNEY KEVIN G Officer | 266 | Direct | Automatic Sale at $1.05 per share. | $279 |
| 1-Apr-08 | SARNEY KEVIN G Officer | 177 | Direct | Disposition (Non Open Market) at $1.10 per share. | $194 |
| 28-Mar-08 | SARNEY KEVIN G Officer | 11,182 | Direct | Statement of Ownership | N/A |
| 16-Mar-08 | KRAMER JANE Officer | 3,087 | Direct | Disposition (Non Open Market) at $1.17 per share. | $3,611 |
| 16-Mar-08 | HAM JAMES G III Officer | 3,383 | Direct | Disposition (Non Open Market) at $1.17 per share. | $3,958 |
| 15-Mar-08 | BRUCE GERALD W Officer | 11,518 | Direct | Disposition (Non Open Market) at $1.17 per share. | $13,476 |
| 16-Jan-08 | WORCEL MANUEL Officer | 102,000 | Direct | Option Exercise at $0.72 per share. | $73,440 |