| INSIDER TRANSACTIONS REPORTED - LAST TWO YEARS |
| Date | Insider | Shares | Type | Transaction | Value* | | 7-Dec-09 | FLYNN JAMES E Beneficial Owner (10% or more) | 29,163 | Indirect | Sale at $7.37 per share. | $214,931 | | 4-Dec-09 | FLYNN JAMES E Beneficial Owner (10% or more) | 20,665 | Indirect | Sale at $7.37 per share. | $152,301 | | 3-Dec-09 | FLYNN JAMES E Beneficial Owner (10% or more) | 156,400 | Indirect | Sale at $7.44 per share. | $1,163,616 | | 9-Oct-09 | FLYNN JAMES E Beneficial Owner (10% or more) | 11,602 | Indirect | Sale at $6.72 - $6.75 per share. | $78,0002 | | 30-Sep-09 | GIANNINI DANIEL A Director | 1,606 | Direct | Acquisition (Non Open Market) at $0 per share. | N/A | | 30-Sep-09 | CHAMBON PHILIPPE Director | 1,532 | Direct | Acquisition (Non Open Market) at $0 per share. | N/A | | 30-Sep-09 | MOORE CRAIG W Director | 1,756 | Direct | Acquisition (Non Open Market) at $0 per share. | N/A | | 30-Sep-09 | REID PERPER Director | 1,457 | Direct | Acquisition (Non Open Market) at $0 per share. | N/A | | 29-Sep-09 | FLYNN JAMES E Beneficial Owner (10% or more) | 3,669 | Indirect | Sale at $7.07 per share. | $25,939 | | 23-Sep-09 | FLYNN JAMES E Beneficial Owner (10% or more) | 33,168 | Indirect | Sale at $6.72 - $6.76 per share. | $224,0002 | | 21-Sep-09 | FLYNN JAMES E Beneficial Owner (10% or more) | 993 | Indirect | Sale at $6.72 per share. | $6,672 | | 18-Sep-09 | FLYNN JAMES E Beneficial Owner (10% or more) | 37,591 | Indirect | Sale at $6.73 per share. | $252,987 | | 17-Sep-09 | FLYNN JAMES E Beneficial Owner (10% or more) | 30,869 | Indirect | Sale at $6.74 per share. | $208,057 | | 16-Sep-09 | FLYNN JAMES E Beneficial Owner (10% or more) | 28,625 | Indirect | Sale at $6.72 per share. | $192,360 | | 15-Sep-09 | FLYNN JAMES E Beneficial Owner (10% or more) | 30,805 | Indirect | Sale at $6.72 per share. | $207,009 | | 14-Sep-09 | FLYNN JAMES E Beneficial Owner (10% or more) | 64,060 | Indirect | Sale at $6.71 - $6.77 per share. | $432,0002 | | 11-Sep-09 | FLYNN JAMES E Beneficial Owner (10% or more) | 103,148 | Indirect | Sale at $6.97 - $6.98 per share. | $719,0002 | | 30-Jun-09 | GIANNINI DANIEL A Director | 2,584 | Direct | Acquisition (Non Open Market) at $0 per share. | N/A | | 30-Jun-09 | CHAMBON PHILIPPE Director | 2,161 | Direct | Acquisition (Non Open Market) at $0 per share. | N/A | | 30-Jun-09 | MOORE CRAIG W Director | 2,584 | Direct | Acquisition (Non Open Market) at $0 per share. | N/A | | 30-Jun-09 | REID PERPER Director | 2,245 | Direct | Acquisition (Non Open Market) at $0 per share. | N/A | | 12-Jun-09 | FLYNN JAMES E Beneficial Owner (10% or more) | 27,078 | Indirect | Sale at $5.96 per share. | $161,384 | | 31-Mar-09 | GIANNINI DANIEL A Director | 5,717 | Direct | Acquisition (Non Open Market) at $0 per share. | N/A | | 31-Mar-09 | CHAMBON PHILIPPE Director | 6,298 | Direct | Acquisition (Non Open Market) at $0 per share. | N/A | | 31-Mar-09 | MOORE CRAIG W Director | 6,298 | Direct | Acquisition (Non Open Market) at $0 per share. | N/A | | 31-Mar-09 | REID PERPER Director | 4,941 | Direct | Acquisition (Non Open Market) at $0 per share. | N/A | | 24-Mar-09 | FLYNN JAMES E Beneficial Owner (10% or more) | 1,789,317 | Indirect | Statement of Ownership | N/A | | 31-Dec-08 | CHAMBON PHILIPPE Director | 93 | Direct | Acquisition (Non Open Market) at $0 per share. | N/A | | 31-Dec-08 | REID PERPER Director | 1,591 | Direct | Acquisition (Non Open Market) at $0 per share. | N/A | | 16-Dec-08 | BURBANK JEFFREY H Officer | 14,146 | Direct | Option Exercise at $0.34 per share. | $4,809 | | 27-Oct-08 | LEWIS EARL R Director | N/A | Direct | Statement of Ownership | N/A | | 30-Sep-08 | GIANNINI DANIEL A Director | 2,843 | Direct | Acquisition (Non Open Market) at $0 per share. | N/A | | 30-Sep-08 | CHAMBON PHILIPPE Director | 3,376 | Direct | Acquisition (Non Open Market) at $0 per share. | N/A | | 30-Sep-08 | MOORE CRAIG W Director | 2,132 | Direct | Acquisition (Non Open Market) at $0 per share. | N/A | | 30-Sep-08 | REID PERPER Director | 3,021 | Direct | Acquisition (Non Open Market) at $0 per share. | N/A | | 26-Aug-08 | ORBIMED ADVISORS LLC Director | 27,700 | Indirect | Purchase at $3.50 per share. | $96,950 | | 25-Aug-08 | ORBIMED ADVISORS LLC Director | 108,900 | Indirect | Purchase at $3.37 per share. | $366,993 | | 21-Aug-08 | PHILDIUS PETER P Director | 13,570 | Direct | Sale at $3.28 per share. | $44,509 | | 21-Aug-08 | ORBIMED ADVISORS LLC Director | 26,100 | Indirect | Purchase at $3.25 per share. | $84,825 | | 13-Aug-08 | PHILDIUS PETER P Director | 6,500 | Direct | Sale at $4.03 per share. | $26,195 | | 12-Aug-08 | MOORE CRAIG W Director | 10,000 | Direct | Purchase at $4 per share. | $40,000 | | 11-Aug-08 | PHILDIUS PETER P Director | 32,170 | Direct | Option Exercise at $0.37 per share. | $11,902 | | 11-Aug-08 | PHILDIUS PETER P Director | 12,100 | Direct | Sale at $4.21 per share. | $50,941 | | 1-Aug-08 | CREDIT SUISSE AG/ Beneficial Owner (10% or more) | 1,022,222 | Indirect | Purchase at $4.50 per share. | $4,599,999 | | 23-Jul-08 | SILVERSTEIN JONATHAN Director | 5,555,556 | Indirect | Statement of Ownership | N/A | | 30-Jun-08 | UTTERBERG DAVID S Director | 2,343 | Direct | Acquisition (Non Open Market) at $0 per share. | N/A | | 30-Jun-08 | GIANNINI DANIEL A Director | 5,533 | Direct | Acquisition (Non Open Market) at $0 per share. | N/A | | 30-Jun-08 | CHAMBON PHILIPPE Director | 5,013 | Direct | Acquisition (Non Open Market) at $0 per share. | N/A | | 30-Jun-08 | MOORE CRAIG W Director | 5,794 | Direct | Acquisition (Non Open Market) at $0 per share. | N/A | | 30-Jun-08 | REID PERPER Director | 4,752 | Direct | Acquisition (Non Open Market) at $0 per share. | N/A | | 23-May-08 | ORBIMED ADVISORS LLC Director | 5,555,556 | Indirect | Purchase at $4.50 per share. | $25,000,002 | | 23-May-08 | ORBIMED ADVISORS LLC Beneficial Owner (10% or more) | 5,555,556 | Indirect | Statement of Ownership | N/A | | 31-Mar-08 | UTTERBERG DAVID S Director | 2,604 | Direct | Acquisition (Non Open Market) at $0 per share. | N/A | | 31-Mar-08 | GIANNINI DANIEL A Director | 3,877 | Direct | Acquisition (Non Open Market) at $0 per share. | N/A | | 31-Mar-08 | SHEA THOMAS Officer | N/A | Direct | Statement of Ownership | N/A | | 31-Mar-08 | CHAMBON PHILIPPE Director | 3,761 | Direct | Acquisition (Non Open Market) at $0 per share. | N/A | | 31-Mar-08 | MOORE CRAIG W Director | 4,340 | Direct | Acquisition (Non Open Market) at $0 per share. | N/A | | 31-Mar-08 | REID PERPER Director | 3,414 | Direct | Acquisition (Non Open Market) at $0 per share. | N/A | | 31-Dec-07 | UTTERBERG DAVID S Director | 543 | Direct | Acquisition (Non Open Market) at $0 per share. | N/A | | 31-Dec-07 | GIANNINI DANIEL A Director | 247 | Direct | Acquisition (Non Open Market) at $0 per share. | N/A | | 31-Dec-07 | CHAMBON PHILIPPE Director | 873 | Direct | Acquisition (Non Open Market) at $0 per share. | N/A | | 31-Dec-07 | MOORE CRAIG W Director | 313 | Direct | Acquisition (Non Open Market) at $0 per share. | N/A | | 31-Dec-07 | REID PERPER Director | 774 | Direct | Acquisition (Non Open Market) at $0 per share. | N/A |
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* = Where indicated, some values are estimates. 1 = Potential proceeds estimated by the filer. 2 = Estimated based on the average of multiple prices reported. 3 = Multiple dates reported. Most recent date shown. |
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