| INSIDER TRANSACTIONS REPORTED - LAST TWO YEARS |
| Date | Insider | Shares | Type | Transaction | Value* | | 25-Nov-09 | JACKSON MICHAEL K Officer | 751 | Direct | Disposition (Non Open Market) at $2.23 per share. | $1,674 | | 15-Nov-09 | JACKSON MICHAEL K Officer | 2,854 | Direct | Acquisition (Non Open Market) at $0 per share. | N/A | | 9-Nov-09 | SIMON NICHOLAS J III Director | 152,052 | Indirect | Sale at $8.50 per share. | $1,292,442 | | 9-Nov-09 | MPM BIOVENTURES III LLC Beneficial Owner (10% or more) | 152,052 | Indirect | Sale at $8.50 per share. | $1,292,442 | | 9-Nov-09 | EVNIN LUKE Beneficial Owner (10% or more) | 152,052 | Indirect | Sale at $8.50 per share. | $1,292,442 | | 6-Nov-09 | SIMON NICHOLAS J III Director | 264,648 | Indirect | Sale at $8.06 per share. | $2,133,062 | | 6-Nov-09 | MPM BIOVENTURES III LLC Beneficial Owner (10% or more) | 264,648 | Indirect | Sale at $8.06 per share. | $2,133,062 | | 6-Nov-09 | EVNIN LUKE Beneficial Owner (10% or more) | 264,648 | Indirect | Sale at $8.06 per share. | $2,133,062 | | 5-Nov-09 | SIMON NICHOLAS J III Director | 78,262 | Indirect | Sale at $8 per share. | $626,096 | | 5-Nov-09 | MPM BIOVENTURES III LLC Beneficial Owner (10% or more) | 78,262 | Indirect | Sale at $8 per share. | $626,096 | | 5-Nov-09 | EVNIN LUKE Beneficial Owner (10% or more) | 78,262 | Indirect | Sale at $8 per share. | $626,096 | | 21-Aug-09 | WEAVER GREGORY L Officer | 3,000 | Direct | Purchase at $7.39 - $7.4 per share. | $22,0002 | | 7-Jul-09 | LYONS GARY A Director | N/A | Direct | Statement of Ownership | N/A | | 2-Jun-09 | JACKSON MICHAEL K Officer | 951 | Direct | Acquisition (Non Open Market) at $0 per share. | N/A | | 6-Apr-09 | WEAVER GREGORY L Officer | 2,000 | Direct | Purchase at $2.05 - $2.1 per share. | $4,1502 | | 3-Apr-09 | BASSO ROBERT S Director | 5,000 | Direct | Purchase at $2.05 per share. | $10,250 | | 2-Apr-09 | JACKSON MICHAEL K Officer | 951 | Direct | Acquisition (Non Open Market) at $0 per share. | N/A | | 27-Mar-09 | CRAVES FRED B Director | 5,000 | Direct | Purchase at $2.12 - $2.15 per share. | $11,0002 | | 26-Mar-09 | CRAVES FRED B Director | 15,000 | Direct | Purchase at $2.05 - $2.15 per share. | $31,0002 | | 18-Feb-09 | WEAVER GREGORY L Officer | 5,000 | Direct | Statement of Ownership | N/A | | 9-Jan-09 | STEVENS DAVID R Director | 6,450 | Direct | Purchase at $3.40 - $3.45 per share. | $22,0002 | | 30-Dec-08 | MCMAHON GERALD PHD Officer | 7,500 | Direct | Purchase at $1.27 - $1.3 per share. | $9,6372 | | 29-Dec-08 | MCMAHON GERALD PHD Officer | 7,375 | Direct | Purchase at $1.40 per share. | $10,325 | | 22-Dec-08 | CRAVES FRED B Director | 2,900 | Direct | Purchase at $1.68 - $1.81 per share. | $5,0602 | | 19-Dec-08 | CRAVES FRED B Director | 25,000 | Direct | Purchase at $1.66 - $1.86 per share. | $44,0002 | | 18-Dec-08 | CRAVES FRED B Director | 26,500 | Direct | Purchase at $1.81 - $1.92 per share. | $49,0002 | | 17-Dec-08 | CRAVES FRED B Director | 13,000 | Direct | Purchase at $1.84 - $2.01 per share. | $25,0002 | | 16-Dec-08 | CRAVES FRED B Director | 11,900 | Direct | Purchase at $1.89 - $2 per share. | $23,0002 | | 6-Mar-08 | LOEWY CAROLINE M Officer | 1,600 | Indirect | Purchase at $3.92 - $3.94 per share. | $6,2882 | | 6-Mar-08 | MCMAHON GERALD PHD Officer | 3,900 | Direct | Purchase at $3.93 per share. | $15,327 | | 5-Mar-08 | LOEWY CAROLINE M Officer | 8,800 | Indirect | Purchase at $3.65 - $3.75 per share. | $33,0002 | | 4-Mar-08 | LOEWY CAROLINE M Officer | 19,600 | Indirect | Purchase at $3.58 - $3.63 per share. | $71,0002 | | 1-Feb-08 | DE JAGER ROBERT Officer | N/A | Direct | Statement of Ownership | N/A | | 15-Jan-08 | STEVENS DAVID R Director | 7,618 | Direct | Purchase at $5.25 per share. | $39,994 | | 11-Jan-08 | CRAVES FRED B Director | 12,600 | Direct | Purchase at $3.87 - $4 per share. | $50,0002 | | 9-Jan-08 | CRAVES FRED B Director | 20,000 | Direct | Purchase at $4.17 - $4.25 per share. | $84,0002 | | 4-Jan-08 | CRAVES FRED B Director | 11,300 | Direct | Purchase at $4.13 - $4.25 per share. | $47,0002 | | 3-Jan-08 | CRAVES FRED B Director | 20,000 | Direct | Purchase at $4.21 - $4.36 per share. | $86,0002 |
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* = Where indicated, some values are estimates. 1 = Potential proceeds estimated by the filer. 2 = Estimated based on the average of multiple prices reported. 3 = Multiple dates reported. Most recent date shown. |
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