| INSIDER TRANSACTIONS REPORTED - LAST TWO YEARS |
| Date | Insider | Shares | Type | Transaction | Value* | | 9-Nov-09 | QUART BARRY D Officer | 10,000 | Direct | Option Exercise at $3.90 per share. | $39,000 | | 28-Oct-09 | MANHARD KIMBERLY Officer | 2,500 | Direct | Option Exercise at $3.90 per share. | $9,750 | | 28-Oct-09 | MANHARD KIMBERLY Officer | 2,500 | Direct | Automatic Sale at $14.20 per share. | $35,500 | | 23-Oct-09 | KRUEGER CHRISTOPHER W Officer | 3,000 | Direct | Option Exercise at $5.20 per share. | $15,600 | | 23-Oct-09 | KRUEGER CHRISTOPHER W Officer | 3,000 | Direct | Automatic Sale at $15.25 per share. | $45,750 | | 12-Oct-09 | FUCHS HENRY J Director | 2,000 | Direct | Option Exercise at $2.76 per share. | $5,520 | | 12-Oct-09 | FUCHS HENRY J Director | 2,000 | Direct | Automatic Sale at $17.08 per share. | $34,160 | | 28-Sep-09 | MANHARD KIMBERLY Officer | 2,500 | Direct | Option Exercise at $3.90 per share. | $9,750 | | 28-Sep-09 | MANHARD KIMBERLY Officer | 2,500 | Direct | Automatic Sale at $19.10 per share. | $47,750 | | 23-Sep-09 | KRUEGER CHRISTOPHER W Officer | 3,000 | Direct | Option Exercise at $5.20 per share. | $15,600 | | 23-Sep-09 | KRUEGER CHRISTOPHER W Officer | 3,000 | Direct | Automatic Sale at $18.67 - $19.49 per share. | $57,0002 | | 10-Sep-09 | FUCHS HENRY J Director | 2,000 | Direct | Option Exercise at $2.76 per share. | $5,520 | | 10-Sep-09 | FUCHS HENRY J Director | 2,000 | Direct | Automatic Sale at $19.31 per share. | $38,620 | | 28-Aug-09 | MANHARD KIMBERLY Officer | 2,500 | Direct | Option Exercise at $3.90 per share. | $9,750 | | 28-Aug-09 | MANHARD KIMBERLY Officer | 2,500 | Direct | Automatic Sale at $18.39 per share. | $45,975 | | 24-Aug-09 | KRUEGER CHRISTOPHER W Officer | 3,000 | Direct | Option Exercise at $5.20 per share. | $15,600 | | 24-Aug-09 | KRUEGER CHRISTOPHER W Officer | 5,061 | Direct | Automatic Sale at $19 per share. | $96,159 | | 14-Aug-09 | BECK JOHN W Officer | 2,500 | Direct | Option Exercise at $5.85 per share. | $14,625 | | 14-Aug-09 | BECK JOHN W Officer | 2,500 | Direct | Automatic Sale at $20.15 per share. | $50,375 | | 13-Aug-09 | QUART BARRY D Officer | 10,000 | Direct | Option Exercise at $3.90 per share. | $39,000 | | 11-Aug-09 | QUART BARRY D Officer | 25,000 | Direct | Option Exercise at $3.90 per share. | $97,500 | | 11-Aug-09 | QUART BARRY D Officer | 25,000 | Direct | Automatic Sale at $19.33 per share. | $483,249 | | 10-Aug-09 | FUCHS HENRY J Director | 2,000 | Direct | Option Exercise at $2.76 per share. | $5,520 | | 10-Aug-09 | FUCHS HENRY J Director | 2,000 | Direct | Automatic Sale at $19.85 per share. | $39,700 | | 27-May-09 | QUART BARRY D Officer | 10,000 | Direct | Disposition (Non Open Market) at $0 per share. | N/A | | 27-May-09 | QUART BARRY D Officer | 2,500 | Indirect | Acquisition (Non Open Market) at $0 per share. | N/A | | 20-May-09 | KRUEGER CHRISTOPHER W Officer | 22,498 | Direct | Option Exercise at $5.20 per share. | $116,989 | | 20-May-09 | KRUEGER CHRISTOPHER W Officer | 24,998 | Direct | Sale at $14.81 - $15.27 per share. | $376,0002 | | 20-May-09 | POYHONEN JOHN Director | 3,000 | Direct | Option Exercise at $5.85 per share. | $17,550 | | 20-May-09 | POYHONEN JOHN Director | 3,000 | Direct | Sale at $15 per share. | $45,000 | | 20-May-09 | BECK JOHN W Officer | 5,000 | Direct | Option Exercise at $5.85 per share. | $29,250 | | 20-May-09 | BECK JOHN W Officer | 5,000 | Direct | Sale at $14.97 per share. | $74,850 | | 20-May-09 | REMINGTON JACK Director | 27,500 | Direct | Option Exercise at $4.08 - $5.85 per share. | N/A | | 20-May-09 | REMINGTON JACK Director | 27,500 | Direct | Sale at $14.95 per share. | $411,125 | | 19-May-09 | KRUEGER CHRISTOPHER W Officer | 2,502 | Direct | Option Exercise at $5.20 per share. | $13,010 | | 19-May-09 | KRUEGER CHRISTOPHER W Officer | 2,502 | Direct | Sale at $15.27 per share. | $38,205 | | 19-May-09 | QUART BARRY D Officer | 30,000 | Direct | Option Exercise at $3.90 per share. | $117,000 | | 19-May-09 | QUART BARRY D Officer | 25,000 | Direct | Sale at $14.90 - $16.3 per share. | $390,0002 | | 19-May-09 | MANHARD KIMBERLY Officer | 25,000 | Direct | Option Exercise at $3.90 per share. | $97,500 | | 19-May-09 | MANHARD KIMBERLY Officer | 21,300 | Direct | Sale at $15.05 per share. | $320,565 | | 19-May-09 | POYHONEN JOHN Director | 5,000 | Direct | Option Exercise at $5.85 per share. | $29,250 | | 19-May-09 | POYHONEN JOHN Director | 5,000 | Direct | Sale at $15.34 per share. | $76,700 | | 23-Jan-09 | BAKER BROS. CAPITAL (GP), LLC Beneficial Owner (10% or more) | 28,066 | Indirect | Disposition (Non Open Market) at $0 per share. | N/A | | 19-Dec-08 | BAKER / TISCH CAPITAL (GP), LLC Beneficial Owner (10% or more) | 3,990 | Indirect | Purchase at $11.14 per share. | $44,448 | | 19-Dec-08 | BAKER BIOTECH CAPITAL (GP), LLC Beneficial Owner (10% or more) | 184,780 | Indirect | Purchase at $11.14 per share. | $2,058,449 | | 19-Dec-08 | BAKER BIOTECH CAPITAL (GP), LLC Beneficial Owner (10% or more) | 184,780 | Indirect | Purchase at $11.14 per share. | $2,058,449 | | 19-Dec-08 | 14159 CAPITAL (GP), LLC Beneficial Owner (10% or more) | 16,093 | Indirect | Purchase at $11.14 per share. | $179,276 | | 19-Dec-08 | BAKER BROTHERS LIFE SCIENCES CAPITAL (GP), LLC Beneficial Owner (10% or more) | 589,169 | Indirect | Purchase at $11.14 per share. | $6,563,342 | | 19-Dec-08 | BAKER BROS. CAPITAL (GP), LLC Beneficial Owner (10% or more) | 820 | Indirect | Purchase at $11.14 per share. | $9,134 | | 17-Dec-08 | TANG KEVIN C Director | 156,652 | Indirect | Purchase at $11.14 per share. | $1,745,103 | | 22-Sep-08 | QUART BARRY D Officer | 5,000 | Direct | Option Exercise at $3.90 per share. | $19,500 | | 17-Sep-08 | TANG KEVIN C Director | 5,700 | Indirect | Option Exercise at $0 per share. | N/A | | 3-Sep-08 | QUART BARRY D Officer | 15,000 | Direct | Option Exercise at $3.90 per share. | $58,500 | | 29-May-08 | BAKER BROS. CAPITAL (GP), LLC Beneficial Owner (10% or more) | 1,218 | Indirect | Disposition (Non Open Market) at $0 per share. | N/A | | 28-May-08 | BAKER BROS. CAPITAL (GP), LLC Beneficial Owner (10% or more) | 30,288 | Indirect | Disposition (Non Open Market) at $0 per share. | N/A | | 7-May-08 | BAKER BROTHERS LIFE SCIENCES CAPITAL (GP), LLC Beneficial Owner (10% or more) | 331,452 | Indirect | Acquisition (Non Open Market) | N/A | | 7-May-08 | BAKER / TISCH CAPITAL (GP), LLC Beneficial Owner (10% or more) | 42,089 | Indirect | Acquisition (Non Open Market) | N/A | | 7-May-08 | BAKER BROS. CAPITAL (GP), LLC Beneficial Owner (10% or more) | 57,873 | Indirect | Acquisition (Non Open Market) | N/A | | 7-May-08 | BAKER BIOTECH CAPITAL (GP), LLC Beneficial Owner (10% or more) | 294,624 | Indirect | Acquisition (Non Open Market) | N/A | | 7-May-08 | TANG KEVIN C Director | 852,308 | Indirect | Acquisition (Non Open Market) | N/A | | 17-Apr-08 | 14159 CAPITAL (GP), LLC Beneficial Owner (10% or more) | 898 | Indirect | Purchase at $13.28 per share. | $11,925 | | 17-Apr-08 | BAKER BROTHERS LIFE SCIENCES CAPITAL (GP), LLC Beneficial Owner (10% or more) | 27,982 | Indirect | Purchase at $13.28 per share. | $371,600 | | 17-Apr-08 | BAKER BROS. CAPITAL (GP), LLC Beneficial Owner (10% or more) | 76 | Indirect | Purchase at $13.28 per share. | $1,009 | | 17-Apr-08 | BAKER BIOTECH CAPITAL (GP), LLC Beneficial Owner (10% or more) | 11,044 | Indirect | Purchase at $13.28 per share. | $146,664 | | 8-Apr-08 | BAKER BROS. CAPITAL (GP), LLC Beneficial Owner (10% or more) | 753 | Indirect | Purchase at $13.28 per share. | $9,999 | | 4-Apr-08 | 14159 CAPITAL (GP), LLC Beneficial Owner (10% or more) | 9,937 | Indirect | Purchase at $13.28 per share. | $131,963 | | 4-Apr-08 | BAKER BROTHERS LIFE SCIENCES CAPITAL (GP), LLC Beneficial Owner (10% or more) | 313,169 | Indirect | Purchase at $13.28 per share. | $4,158,884 | | 4-Apr-08 | BAKER BIOTECH CAPITAL (GP), LLC Beneficial Owner (10% or more) | 76,141 | Indirect | Purchase at $13.28 per share. | $1,011,152 | | 9-Jan-08 | ANDREEFF DANE Beneficial Owner (10% or more) | 277 | Indirect | Purchase at $15.94 per share. | $4,415 | | 31-Dec-07 | ANDREEFF DANE Beneficial Owner (10% or more) | 4,200 | Indirect | Purchase at $15.16 - $15.19 per share. | $64,0002 | | 26-Dec-07 | ANDREEFF DANE Beneficial Owner (10% or more) | 8,100 | Indirect | Purchase at $15.18 per share. | $122,958 | | 19-Dec-07 | 14159 CAPITAL (GP), LLC Beneficial Owner (10% or more) | 23,968 | Indirect | Purchase at $13.25 per share. | $317,576 | | 19-Dec-07 | BAKER BROTHERS LIFE SCIENCES CAPITAL (GP), LLC Beneficial Owner (10% or more) | 754,519 | Indirect | Purchase at $13.25 per share. | $9,997,376 | | 19-Dec-07 | BAKER / TISCH CAPITAL (GP), LLC Beneficial Owner (10% or more) | 15,754 | Indirect | Purchase at $13.25 per share. | $208,740 | | 19-Dec-07 | BAKER BROS. CAPITAL (GP), LLC Beneficial Owner (10% or more) | 2,059 | Indirect | Purchase at $13.25 per share. | $27,281 | | 19-Dec-07 | BAKER BIOTECH CAPITAL (GP), LLC Beneficial Owner (10% or more) | 298,040 | Indirect | Purchase at $13.25 per share. | $3,949,030 | | 19-Dec-07 | TANG KEVIN C Director | 37,731 | Indirect | Purchase at $13.25 per share. | $499,935 | | 13-Dec-07 | HICKEY DENIS Officer | 4,200 | Direct | Sale at $12.75 - $13 per share. | $54,0002 | | 6-Dec-07 | TANG KEVIN C Director | 14,000 | Indirect | Purchase at $12.75 per share. | $178,500 | | 5-Dec-07 | REMINGTON JACK Director | 15,834 | Direct | Option Exercise at $2.76 - $3.5 per share. | N/A | | 5-Dec-07 | REMINGTON JACK Director | 15,834 | Direct | Sale at $11.30 - $11.49 per share. | $180,0002 | | 5-Dec-07 | FUCHS HENRY J Director | 2,899 | Direct | Option Exercise at $2.76 per share. | $8,001 | | 5-Dec-07 | TANG KEVIN C Director | 39,000 | Indirect | Purchase at $11.78 - $11.78 per share. | $459,0002 | | 4-Dec-07 | FUCHS HENRY J Director | 80,208 | Direct | Option Exercise at $2.76 - $2.76 per share. | $221,0002 | | 4-Dec-07 | FUCHS HENRY J Director | 83,107 | Direct | Sale at $10.78 - $10.78 per share. | $896,0002 | | 4-Dec-07 | TANG KEVIN C Director | 55,850 | Indirect | Purchase at $10.76 - $10.81 per share. | $602,0002 |
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* = Where indicated, some values are estimates. 1 = Potential proceeds estimated by the filer. 2 = Estimated based on the average of multiple prices reported. 3 = Multiple dates reported. Most recent date shown. |
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