| INSIDER TRANSACTIONS REPORTED - LAST TWO YEARS |
| Date | Insider | Shares | Type | Transaction | Value* | | 16-Jul-08 | VENTURI I, LLC Beneficial Owner (10% or more) | 1,560,141 | Direct | Disposition (Non Open Market) | N/A | | 16-Jul-08 | MPM BIOVENTURES II QP LP Beneficial Owner (10% or more) | 3,979,078 | Indirect | Disposition (Non Open Market) | N/A | | 16-Jul-08 | EVNIN LUKE Director | 3,979,078 | Indirect | Disposition (Non Open Market) | N/A | | 16-Jul-08 | RADICHEL PHILIP E Officer | 7,700 | Direct | Disposition (Non Open Market) | N/A | | 16-Jul-08 | KNUDSON MARK B Director | 810,141 | Indirect | Disposition (Non Open Market) | N/A | | 16-Jul-08 | KNUDSON MARK B Director | 2,011 | Direct | Disposition (Non Open Market) | N/A | | 16-Jul-08 | LISZT HOWARD P Director | 5,000 | Direct | Disposition (Non Open Market) | N/A | | 16-Jul-08 | PAULSON J ROBERT JR Officer | 35,770 | Direct | Disposition (Non Open Market) | N/A |
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* = Where indicated, some values are estimates. 1 = Potential proceeds estimated by the filer. 2 = Estimated based on the average of multiple prices reported. 3 = Multiple dates reported. Most recent date shown. |
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