| INSIDER TRANSACTIONS REPORTED - LAST TWO YEARS |
| Date | Insider | Shares | Type | Transaction | Value* | | 9-Nov-09 | COOPER GLENN L MD Director | 5,000 | Direct | Purchase at $4.98 per share. | $24,900 | | 7-Jul-09 | BVF PARTNERS L P/IL Beneficial Owner (10% or more) | 1,000 | Direct | Sale at $5.50 per share. | $5,500 | | 6-Jul-09 | BVF PARTNERS L P/IL Beneficial Owner (10% or more) | 450,800 | Direct | Sale at $5.52 per share. | $2,488,416 | | 15-May-09 | BVF PARTNERS L P/IL Beneficial Owner (10% or more) | 3,216,850 | Indirect | Statement of Ownership | N/A | | 15-May-09 | BVF PARTNERS L P/IL Beneficial Owner (10% or more) | 1,856,700 | Direct | Statement of Ownership | N/A | | 5-Jan-09 | BENJAMIN HOWARD Other | 10,000 | Direct | Acquisition (Non Open Market) at $0.01 per share. | $100 | | 1-Dec-08 | DAWES KAREN A Director | 2,000 | Direct | Purchase at $3.50 per share. | $7,000 | | 9-Sep-08 | RICH ALEXANDER Director | 5,000 | Direct | Option Exercise at $1.28 per share. | $6,400 | | 9-Sep-08 | RICH ALEXANDER Director | 5,000 | Direct | Sale at $5.05 per share. | $25,250 | | 31-Mar-08 | KELLY WILLIAM J Officer | 5,000 | Direct | Acquisition (Non Open Market) at $0.01 per share. | $50 | | 4-Mar-08 | WITT DANIEL P Officer | 5,000 | Indirect | Sale at $5.28 - $5.52 per share. | $27,0002 | | 20-Feb-08 | WITT DANIEL P Officer | 2,200 | Direct | Sale at $5.80 - $5.81 per share. | $13,0002 | | 20-Feb-08 | WITT DANIEL P Officer | 44,834 | Indirect | Disposition (Non Open Market) at $0 per share. | N/A | | 19-Feb-08 | WITT DANIEL P Officer | 2,035 | Direct | Sale at $6.10 - $6.12 per share. | $12,0002 | | 15-Feb-08 | WITT DANIEL P Officer | 1,600 | Direct | Sale at $6.33 - $6.35 per share. | $10,0002 | | 14-Feb-08 | WITT DANIEL P Officer | 10,000 | Direct | Option Exercise at $1.41 per share. | $14,100 | | 14-Feb-08 | WITT DANIEL P Officer | 10,699 | Direct | Sale at $6.30 - $6.34 per share. | $68,0002 | | 13-Dec-07 | RUSCHE JAMES R Officer | 30,000 | Direct | Option Exercise at $1.41 per share. | $42,300 | | 13-Dec-07 | RUSCHE JAMES R Officer | 20,000 | Direct | Sale at $6.12 - $6.17 per share. | $123,0002 | | 13-Dec-07 | HERLIHY WALTER C Officer | 50,000 | Direct | Disposition (Non Open Market) at $6.10 - $6.15 per share. | $306,0002 |
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* = Where indicated, some values are estimates. 1 = Potential proceeds estimated by the filer. 2 = Estimated based on the average of multiple prices reported. 3 = Multiple dates reported. Most recent date shown. |
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