| Insider Transactions Reported - Last Two Years |
|---|
| Date | Insider | Shares | Type | Transaction | Value* |
|---|
| Jun 13, 2013 | AKKARAJU SRINIVASDirector | 5,000 | Direct | Sale at $32.75 per share. | 163,750 | | Jun 13, 2013 | AKKARAJU SRINIVASDirector | 5,000 | Direct | Option Exercise at $8.38 per share. | 41,900 | | Jun 12, 2013 | HIMES VAUGHN BOfficer | 10,000 | Direct | Option Exercise at $9.23 per share. | 92,299 | | Jun 12, 2013 | HIMES VAUGHN BOfficer | 10,000 | Direct | Sale at $32.11 per share. | 321,100 | | Jun 2, 2013 | SIEGALL CLAY BOfficer | 2,000 | Direct | Option Exercise at $10.33 per share. | 20,660 | | Jun 2, 2013 | SIEGALL CLAY BOfficer | 2,000 | Direct | Automatic Sale at $33.88 per share. | 67,760 | | May 16, 2013 | LIPPMAN MARC EDirector | 3,500 | Direct | Acquisition (Non Open Market) at $0 per share. | N/A | | May 16, 2013 | AKKARAJU SRINIVASDirector | 3,500 | Direct | Acquisition (Non Open Market) at $0 per share. | N/A | | May 16, 2013 | WELCH DANIEL GDirector | 3,500 | Direct | Acquisition (Non Open Market) at $0 per share. | N/A | | May 16, 2013 | 667, L.P.Director | 3,868,576 | Direct | Statement of Ownership | N/A | | May 16, 2013 | BAKER BROTHERS LIFE SCIENCES LPDirector | 15,131,223 | Direct | Statement of Ownership | N/A | | May 16, 2013 | SIMONIAN NANCY ADirector | 3,500 | Direct | Acquisition (Non Open Market) at $0 per share. | N/A | | May 16, 2013 | BERGER FRANKLIN MDirector | 3,500 | Direct | Acquisition (Non Open Market) at $0 per share. | N/A | | May 16, 2013 | MCLAUGHLIN JOHN PETERDirector | 3,500 | Direct | Acquisition (Non Open Market) at $0 per share. | N/A | | May 16, 2013 | GRYSKA DAVID WDirector | 3,500 | Direct | Acquisition (Non Open Market) at $0 per share. | N/A | | May 16, 2013 | 14159, L.P.Director | 323,148 | Direct | Statement of Ownership | N/A | | May 16, 2013 | BAKER FELIXDirector | 10,500 | Indirect | Acquisition (Non Open Market) at $0 per share. | N/A | | May 9, 2013 | AKKARAJU SRINIVASDirector | 17,500 | Direct | Option Exercise at $12.76 per share. | 223,300 | | May 9, 2013 | AKKARAJU SRINIVASDirector | 17,500 | Direct | Sale at $37.17 per share. | 650,474 | | Apr 30, 2013 | SIEGALL CLAY BOfficer | 2,000 | Direct | Option Exercise at $10.33 per share. | 20,660 | | Apr 30, 2013 | SIEGALL CLAY BOfficer | 2,000 | Direct | Automatic Sale at $36.58 per share. | 73,160 | | Mar 31, 2013 | SIEGALL CLAY BOfficer | 2,000 | Direct | Option Exercise at $10.33 per share. | 20,660 | | Mar 31, 2013 | SIEGALL CLAY BOfficer | 2,000 | Direct | Automatic Sale at $35.53 per share. | 71,060 | | Mar 14, 2013 | BOERNER CHRISTOPHER S.Officer | 8,500 | Direct | Option Exercise at $15.10 per share. | 128,350 | | Mar 14, 2013 | BOERNER CHRISTOPHER S.Officer | 8,500 | Direct | Sale at $33.61 per share. | 285,685 | | Mar 10, 2013 | DOBMEIER ERICOfficer | 60,000 | Direct | Sale at $31.15 - $31.16 per share. | 1,869,0002 | | Mar 10, 2013 | DOBMEIER ERICOfficer | 50,000 | Direct | Option Exercise at $12 - $12.16 per share. | 604,0002 | | Mar 6, 2013 | SIMPSON TODD EOfficer | 20,176 | Direct | Option Exercise at $11.09 - $12.16 per share. | 235,0002 | | Mar 6, 2013 | SIMPSON TODD EOfficer | 49,718 | Direct | Sale at $30.70 - $30.78 per share. | 1,528,0002 | | Mar 5, 2013 | DOBMEIER ERICOfficer | 50,000 | Direct | Sale at $30.42 per share. | 1,521,000 | | Mar 5, 2013 | DOBMEIER ERICOfficer | 50,000 | Direct | Option Exercise at $12 per share. | 600,000 | | Mar 4, 2013 | SIEGALL CLAY BOfficer | 68,750 | Direct | Sale at $28.87 per share. | 1,984,812 | | Mar 4, 2013 | DOBMEIER ERICOfficer | 12,567 | Direct | Sale at $28.95 per share. | 363,814 | | Mar 4, 2013 | DOBMEIER ERICOfficer | 12,567 | Direct | Option Exercise at $12.16 per share. | 152,814 | | Mar 3, 2013 | DOBMEIER ERICOfficer | 37,433 | Direct | Sale at $28.95 per share. | 1,083,685 | | Mar 3, 2013 | DOBMEIER ERICOfficer | 37,433 | Direct | Option Exercise at $12.16 per share. | 455,185 | | Feb 28, 2013 | SIEGALL CLAY BOfficer | 25,000 | Direct | Sale at $28.31 per share. | 707,750 | | Feb 28, 2013 | SIEGALL CLAY BOfficer | 2,000 | Direct | Automatic Sale at $28.12 per share. | 56,240 | | Feb 28, 2013 | SIEGALL CLAY BOfficer | 2,000 | Direct | Option Exercise at $10.33 per share. | 20,660 | | Feb 25, 2013 | GRYSKA DAVID WDirector | 10,000 | Direct | Option Exercise at $5 - $8.38 per share. | N/A | | Feb 24, 2013 | GRYSKA DAVID WDirector | 10,000 | Direct | Sale at $27.17 per share. | 271,700 | | Jan 31, 2013 | SIEGALL CLAY BOfficer | 2,000 | Direct | Automatic Sale at $29.61 per share. | 59,220 | | Jan 31, 2013 | SIEGALL CLAY BOfficer | 2,000 | Direct | Option Exercise at $10.33 per share. | 20,660 | | Jan 27, 2013 | REYNOLDS THOMAS COfficer | 5,207 | Direct | Automatic Sale at $30.19 per share. | 157,199 | | Jan 27, 2013 | REYNOLDS THOMAS COfficer | 5,207 | Direct | Option Exercise at $12 - $12.16 per share. | 63,0002 | | Jan 24, 2013 | REYNOLDS THOMAS COfficer | 2,083 | Direct | Option Exercise at $15.46 per share. | 32,203 | | Jan 24, 2013 | REYNOLDS THOMAS COfficer | 2,083 | Direct | Automatic Sale at $29.84 per share. | 62,156 | | Jan 14, 2013 | REYNOLDS THOMAS COfficer | 125,079 | Direct | Option Exercise at $11.09 - $15.46 per share. | N/A | | Jan 14, 2013 | REYNOLDS THOMAS COfficer | 125,079 | Direct | Automatic Sale at $28 - $28.01 per share. | 3,503,0002 | | Jan 3, 2013 | SIEGALL CLAY BOfficer | 2,000 | Direct | Option Exercise at $10.33 per share. | 20,660 | | Jan 3, 2013 | DOBMEIER ERICOfficer | 50,983 | Direct | Automatic Sale at $24.95 per share. | 1,272,025 | | Jan 3, 2013 | SIEGALL CLAY BOfficer | 2,000 | Direct | Automatic Sale at $25.05 per share. | 50,100 | | Jan 3, 2013 | DOBMEIER ERICOfficer | 60,000 | Direct | Option Exercise at $11.09 per share. | 665,400 | | Jan 1, 2013 | SIEGALL CLAY BOfficer | 6,249 | Direct | Automatic Sale at $23.83 per share. | 148,913 | | Jan 1, 2013 | SIEGALL CLAY BOfficer | 6,249 | Direct | Option Exercise at $3.30 per share. | 20,621 | | Dec 16, 2012 | DOBMEIER ERICOfficer | 50,000 | Direct | Automatic Sale at $23.70 per share. | 1,185,000 | | Dec 16, 2012 | DOBMEIER ERICOfficer | 62,418 | Direct | Option Exercise at $10.20 - $11.09 per share. | 664,0002 | | Dec 9, 2012 | REYNOLDS THOMAS COfficer | 6,588 | Direct | Option Exercise at $10.29 - $11.09 per share. | 70,0002 | | Dec 9, 2012 | REYNOLDS THOMAS COfficer | 6,588 | Direct | Sale at $25.75 per share. | 169,641 | | Dec 6, 2012 | REYNOLDS THOMAS COfficer | 30,000 | Direct | Option Exercise at $10.29 per share. | 308,700 | | Dec 6, 2012 | REYNOLDS THOMAS COfficer | 30,000 | Direct | Sale at $25.77 per share. | 773,100 | | Dec 5, 2012 | REYNOLDS THOMAS COfficer | 30,000 | Direct | Option Exercise at $12.16 per share. | 364,800 | | Dec 5, 2012 | REYNOLDS THOMAS COfficer | 30,000 | Direct | Sale at $25.77 per share. | 773,100 | | Dec 4, 2012 | LIPPMAN MARC EDirector | 67,500 | Direct | Option Exercise at $3.50 - $10.2 per share. | N/A | | Dec 4, 2012 | REYNOLDS THOMAS COfficer | 10,000 | Direct | Sale at $25.60 per share. | 256,000 | | Dec 4, 2012 | REYNOLDS THOMAS COfficer | 10,000 | Direct | Option Exercise at $12.16 per share. | 121,600 | | Dec 4, 2012 | LIPPMAN MARC EDirector | 67,500 | Direct | Sale at $25.54 per share. | 1,723,950 | | Dec 3, 2012 | REYNOLDS THOMAS COfficer | 30,000 | Direct | Sale at $25.45 - $25.75 per share. | 768,0002 | | Dec 3, 2012 | REYNOLDS THOMAS COfficer | 30,000 | Direct | Option Exercise at $12 - $12.16 per share. | 362,0002 | | Dec 2, 2012 | SIEGALL CLAY BOfficer | 8,250 | Direct | Automatic Sale at $25.19 per share. | 207,817 | | Dec 2, 2012 | SIEGALL CLAY BOfficer | 8,250 | Direct | Option Exercise at $3.30 per share. | 27,225 | | Dec 2, 2012 | REYNOLDS THOMAS COfficer | 10,000 | Direct | Option Exercise at $12.16 per share. | 121,600 | | Dec 2, 2012 | WELCH DANIEL GDirector | 3,119 | Direct | Option Exercise at $8.38 per share. | 26,137 | | Dec 2, 2012 | REYNOLDS THOMAS COfficer | 10,000 | Direct | Sale at $25.45 per share. | 254,500 | | Nov 29, 2012 | REYNOLDS THOMAS COfficer | 10,000 | Direct | Option Exercise at $12 - $12.16 per share. | 121,0002 | | Nov 29, 2012 | REYNOLDS THOMAS COfficer | 10,000 | Direct | Sale at $25.50 per share. | 255,000 | | Nov 28, 2012 | REYNOLDS THOMAS COfficer | 20,000 | Direct | Sale at $25.25 - $25.5 per share. | 508,0002 | | Nov 28, 2012 | REYNOLDS THOMAS COfficer | 20,000 | Direct | Option Exercise at $12 per share. | 240,000 | | Nov 25, 2012 | REYNOLDS THOMAS COfficer | 3,000 | Direct | Sale at $25.50 per share. | 76,500 | | Nov 25, 2012 | REYNOLDS THOMAS COfficer | 3,000 | Direct | Option Exercise at $12 per share. | 36,000 | | Nov 22, 2012 | REYNOLDS THOMAS COfficer | 17,000 | Direct | Sale at $25.26 - $25.5 per share. | 431,0002 | | Nov 22, 2012 | REYNOLDS THOMAS COfficer | 17,000 | Direct | Option Exercise at $12 per share. | 204,000 | | Nov 20, 2012 | REYNOLDS THOMAS COfficer | 10,000 | Direct | Sale at $25.25 per share. | 252,500 | | Nov 20, 2012 | REYNOLDS THOMAS COfficer | 10,000 | Direct | Option Exercise at $15.46 per share. | 154,600 | | Nov 19, 2012 | REYNOLDS THOMAS COfficer | 10,000 | Direct | Option Exercise at $12 - $15.46 per share. | N/A | | Nov 19, 2012 | REYNOLDS THOMAS COfficer | 10,000 | Direct | Sale at $25 per share. | 250,000 | | Nov 18, 2012 | REYNOLDS THOMAS COfficer | 10,000 | Direct | Sale at $24.90 per share. | 249,000 | | Nov 18, 2012 | REYNOLDS THOMAS COfficer | 10,000 | Direct | Option Exercise at $15.46 per share. | 154,600 | | Nov 12, 2012 | DOBMEIER ERICOfficer | 24,811 | Direct | Option Exercise at $10.29 per share. | 255,305 | | Nov 12, 2012 | DOBMEIER ERICOfficer | 27,327 | Direct | Sale at $23.59 - $23.6 per share. | 645,0002 | | Nov 7, 2012 | DOBMEIER ERICOfficer | 34,575 | Direct | Option Exercise at $4.45 - $10.33 per share. | N/A | | Nov 7, 2012 | SIMPSON TODD EOfficer | 72,737 | Direct | Option Exercise at $5.20 - $5.63 per share. | 394,0002 | | Oct 31, 2012 | SIEGALL CLAY BOfficer | 8,250 | Direct | Option Exercise at $3.30 - $10.33 per share. | N/A | | Oct 31, 2012 | SIEGALL CLAY BOfficer | 8,250 | Direct | Automatic Sale at $25.51 per share. | 210,457 | | Oct 14, 2012 | DOBMEIER ERICOfficer | 25,000 | Direct | Option Exercise at $10.29 per share. | 257,250 | | Oct 14, 2012 | DOBMEIER ERICOfficer | 25,000 | Direct | Automatic Sale at $25.01 per share. | 625,250 | | Sep 30, 2012 | SIEGALL CLAY BOfficer | 8,250 | Direct | Option Exercise at $3.30 - $10.33 per share. | N/A | | Sep 30, 2012 | SIEGALL CLAY BOfficer | 8,250 | Direct | Automatic Sale at $26.59 per share. | 219,367 | | Sep 9, 2012 | HIMES VAUGHN BOfficer | 10,000 | Direct | Sale at $28.79 per share. | 287,900 | | Sep 9, 2012 | HIMES VAUGHN BOfficer | 10,000 | Direct | Option Exercise at $9.23 per share. | 92,299 | | Sep 5, 2012 | REYNOLDS THOMAS COfficer | 48,540 | Direct | Automatic Sale at $29.75 per share. | 1,444,065 | | Sep 5, 2012 | REYNOLDS THOMAS COfficer | 48,540 | Direct | Option Exercise at $8.24 per share. | 399,969 | | Sep 5, 2012 | SIMPSON TODD EOfficer | 50,000 | Direct | Automatic Sale at $28.97 per share. | 1,448,500 | | Sep 5, 2012 | SIMPSON TODD EOfficer | 50,000 | Direct | Option Exercise at $12.16 per share. | 608,000 | | Sep 4, 2012 | SIMPSON TODD EOfficer | 45,000 | Direct | Automatic Sale at $27.97 per share. | 1,258,650 | | Sep 4, 2012 | SIMPSON TODD EOfficer | 45,000 | Direct | Option Exercise at $11.09 - $12.16 per share. | 523,0002 | | Sep 3, 2012 | SIEGALL CLAY BOfficer | 8,250 | Direct | Option Exercise at $3.30 - $10.33 per share. | N/A | | Sep 3, 2012 | SIEGALL CLAY BOfficer | 8,250 | Direct | Automatic Sale at $26.54 per share. | 218,955 | | Aug 26, 2012 | SIMPSON TODD EOfficer | 31,000 | Direct | Option Exercise at $10.29 - $11.09 per share. | 331,0002 | | Aug 26, 2012 | SIMPSON TODD EOfficer | 31,000 | Direct | Automatic Sale at $26.97 per share. | 836,070 | | Aug 23, 2012 | SIMPSON TODD EOfficer | 14,000 | Direct | Option Exercise at $10.29 per share. | 144,060 | | Aug 23, 2012 | SIMPSON TODD EOfficer | 14,000 | Direct | Automatic Sale at $26.97 per share. | 377,580 | | Aug 22, 2012 | BERGER FRANKLIN MDirector | 20,000 | Direct | Option Exercise at $10.08 - $10.2 per share. | 203,0002 | | Aug 19, 2012 | BOERNER CHRISTOPHER S.Officer | 12,000 | Direct | Acquisition (Non Open Market) at $0 per share. | N/A | | Aug 19, 2012 | HIMES VAUGHN BOfficer | 16,000 | Direct | Acquisition (Non Open Market) at $0 per share. | N/A | | Aug 19, 2012 | REYNOLDS THOMAS COfficer | 26,000 | Direct | Acquisition (Non Open Market) at $0 per share. | N/A | | Aug 19, 2012 | SIMPSON TODD EOfficer | 20,000 | Direct | Acquisition (Non Open Market) at $0 per share. | N/A | | Aug 19, 2012 | DOBMEIER ERICOfficer | 26,000 | Direct | Acquisition (Non Open Market) at $0 per share. | N/A | | Aug 19, 2012 | SIEGALL CLAY BOfficer | 74,250 | Direct | Acquisition (Non Open Market) at $0 per share. | N/A | | Aug 15, 2012 | SIMPSON TODD EOfficer | 40,000 | Direct | Option Exercise at $10.29 per share. | 411,600 | | Aug 15, 2012 | SIMPSON TODD EOfficer | 40,000 | Direct | Automatic Sale at $25.97 per share. | 1,038,800 | | Aug 12, 2012 | DOBMEIER ERICOfficer | 25,000 | Direct | Automatic Sale at $24.01 per share. | 600,250 | | Aug 9, 2012 | GRYSKA DAVID WDirector | 7,500 | Direct | Option Exercise at $5 per share. | 37,500 | | Aug 1, 2012 | SIEGALL CLAY BOfficer | 458 | Direct | Automatic Sale at $25.22 per share. | 11,550 | | Aug 1, 2012 | SIEGALL CLAY BOfficer | 458 | Direct | Option Exercise at $3.30 per share. | 1,511 | | Jul 31, 2012 | SIEGALL CLAY BOfficer | 7,792 | Direct | Option Exercise at $3.30 - $10.33 per share. | N/A | | Jul 31, 2012 | SIEGALL CLAY BOfficer | 7,792 | Direct | Automatic Sale at $26.04 per share. | 202,903 | | Jul 26, 2012 | WELCH DANIEL GDirector | 3,000 | Direct | Option Exercise at $19.02 per share. | 57,060 | | Jul 1, 2012 | SIEGALL CLAY BOfficer | 8,250 | Direct | Option Exercise at $3.30 - $10.33 per share. | N/A | | Jul 1, 2012 | SIEGALL CLAY BOfficer | 8,250 | Direct | Automatic Sale at $25.36 per share. | 209,220 | | Jun 17, 2012 | DOBMEIER ERICOfficer | 25,000 | Direct | Option Exercise at $10.29 per share. | 257,250 | | Jun 17, 2012 | DOBMEIER ERICOfficer | 25,000 | Direct | Automatic Sale at $25.36 per share. | 634,000 | | Jun 14, 2012 | FBB2 LLCDirector | 18,243 | Direct | Statement of Ownership | N/A | | Jun 13, 2012 | SIMPSON TODD EOfficer | 50,000 | Direct | Option Exercise at $5.20 - $5.63 per share. | 271,0002 | | Jun 13, 2012 | SIMPSON TODD EOfficer | 50,000 | Direct | Automatic Sale at $24.97 per share. | 1,248,500 | | Jun 11, 2012 | ROSENBERG MORRISOfficer | 10,000 | Direct | Automatic Sale at $24 per share. | 240,000 | | Jun 11, 2012 | SIMPSON TODD EOfficer | 45,000 | Direct | Automatic Sale at $23.97 per share. | 1,078,650 | | Jun 11, 2012 | ROSENBERG MORRISOfficer | 10,000 | Direct | Option Exercise at $10.29 per share. | 102,900 | | Jun 11, 2012 | SIMPSON TODD EOfficer | 45,000 | Direct | Option Exercise at $5.20 per share. | 233,999 | | Jun 7, 2012 | SIMPSON TODD EOfficer | 35,000 | Direct | Option Exercise at $5.20 per share. | 182,000 | | Jun 7, 2012 | SIMPSON TODD EOfficer | 35,000 | Direct | Automatic Sale at $22.97 per share. | 803,950 | | Jun 6, 2012 | ROSENBERG MORRISOfficer | 13,566 | Direct | Option Exercise at $10.29 per share. | 139,594 | | Jun 6, 2012 | ROSENBERG MORRISOfficer | 13,566 | Direct | Automatic Sale at $22.50 per share. | 305,235 | | Jun 4, 2012 | GRYSKA DAVID WDirector | 8,000 | Direct | Sale at $19.75 per share. | 158,000 | | May 17, 2012 | ROSENBERG MORRISOfficer | 64,800 | Direct | Option Exercise at $4.45 per share. | 288,360 | | May 17, 2012 | ROSENBERG MORRISOfficer | 64,800 | Direct | Automatic Sale at $20.80 - $21.8 per share. | 1,380,0002 | | May 15, 2012 | ROSENBERG MORRISOfficer | 200 | Direct | Option Exercise at $4.45 per share. | 889 | | May 15, 2012 | ROSENBERG MORRISOfficer | 200 | Direct | Automatic Sale at $20.80 per share. | 4,160 | | May 14, 2012 | REYNOLDS THOMAS COfficer | 949 | Direct | Automatic Sale at $19.75 per share. | 18,742 | | May 14, 2012 | REYNOLDS THOMAS COfficer | 949 | Direct | Option Exercise at $8.24 per share. | 7,819 | | Apr 24, 2012 | DOBMEIER ERICOfficer | 25,000 | Direct | Option Exercise at $10.20 - $10.29 per share. | 256,0002 | | Apr 24, 2012 | REYNOLDS THOMAS COfficer | 40,000 | Direct | Automatic Sale at $19.75 per share. | 790,000 | | Apr 24, 2012 | REYNOLDS THOMAS COfficer | 40,000 | Direct | Option Exercise at $8.24 per share. | 329,600 | | Apr 24, 2012 | DOBMEIER ERICOfficer | 25,000 | Direct | Automatic Sale at $19.95 per share. | 498,750 | | Apr 19, 2012 | ROSENBERG MORRISOfficer | 38,281 | Direct | Automatic Sale at $19.51 per share. | 746,862 | | Apr 19, 2012 | ROSENBERG MORRISOfficer | 38,281 | Direct | Option Exercise at $5.63 per share. | 215,522 | | Apr 16, 2012 | ROSENBERG MORRISOfficer | 44,219 | Direct | Option Exercise at $5.63 - $5.92 per share. | 255,0002 | | Apr 16, 2012 | ROSENBERG MORRISOfficer | 30,000 | Direct | Sale at $18.88 per share. | 566,400 | | Apr 16, 2012 | ROSENBERG MORRISOfficer | 14,219 | Direct | Automatic Sale at $18.88 per share. | 268,454 | | Apr 11, 2012 | BAKER BROS ADVISORS LLCDirector | N/A | Indirect | Statement of Ownership | N/A | | Mar 21, 2012 | REYNOLDS THOMAS COfficer | 40,000 | Direct | Option Exercise at $8.24 per share. | 329,600 | | Mar 21, 2012 | REYNOLDS THOMAS COfficer | 40,000 | Direct | Automatic Sale at $19.78 per share. | 791,200 | | Mar 18, 2012 | SIEGALL CLAY BOfficer | 5,000 | Direct | Disposition (Non Open Market) at $0 per share. | N/A | | Mar 18, 2012 | LIPPMAN MARC EDirector | 7,500 | Direct | Option Exercise at $4.97 per share. | 37,275 | | Mar 18, 2012 | REYNOLDS THOMAS COfficer | 37,700 | Direct | Automatic Sale at $19.75 per share. | 744,575 | | Mar 18, 2012 | REYNOLDS THOMAS COfficer | 37,700 | Direct | Option Exercise at $8.24 per share. | 310,648 | | Mar 15, 2012 | REYNOLDS THOMAS COfficer | 2,300 | Direct | Automatic Sale at $19.75 per share. | 45,425 | | Mar 15, 2012 | REYNOLDS THOMAS COfficer | 2,300 | Direct | Option Exercise at $8.24 per share. | 18,952 | | Mar 12, 2012 | ROSENBERG MORRISOfficer | 69,626 | Direct | Sale at $18.59 per share. | 1,294,347 | | Mar 12, 2012 | ROSENBERG MORRISOfficer | 69,626 | Direct | Option Exercise at $3.30 - $10.33 per share. | N/A | | Feb 28, 2012 | BOERNER CHRISTOPHER S.Officer | 14,000 | Direct | Acquisition (Non Open Market) at $0 per share. | N/A | | Feb 27, 2012 | DOBMEIER ERICOfficer | 46,000 | Direct | Sale at $18.52 per share. | 851,920 | | Feb 27, 2012 | DOBMEIER ERICOfficer | 46,000 | Direct | Option Exercise at $10.20 - $10.33 per share. | 472,0002 | | Feb 21, 2012 | BOERNER CHRISTOPHER S.Officer | 7,348 | Direct | Statement of Ownership | N/A | | Jan 26, 2012 | REYNOLDS THOMAS COfficer | 40,000 | Direct | Automatic Sale at $19.75 per share. | 790,000 | | Jan 26, 2012 | REYNOLDS THOMAS COfficer | 40,000 | Direct | Option Exercise at $8.24 per share. | 329,600 | | Jan 2, 2012 | SIEGALL CLAY BOfficer | 15,000 | Direct | Automatic Sale at $16.73 per share. | 250,950 | | Jan 2, 2012 | SIEGALL CLAY BOfficer | 15,000 | Direct | Option Exercise at $6.34 per share. | 95,100 | | Dec 29, 2011 | BAKER BIOTECH CAPITAL (GP), LLCDirector | 339,788 | Indirect | Option Exercise at $6.25 per share. | 2,123,675 | | Dec 29, 2011 | BAKER / TISCH CAPITAL (GP), LLCDirector | 49,563 | Indirect | Option Exercise at $6.25 per share. | 309,768 | | Dec 29, 2011 | BAKER BROTHERS LIFE SCIENCES CAPITAL (GP), LLCDirector | 355,143 | Indirect | Option Exercise at $6.25 per share. | 2,219,643 | | Dec 29, 2011 | BAKER BROS. CAPITAL (GP), LLCDirector | 68,006 | Indirect | Option Exercise at $6.25 per share. | 425,037 | | Dec 21, 2011 | DOBMEIER ERICOfficer | 10,000 | Direct | Option Exercise at $4.45 per share. | 44,500 | | Dec 14, 2011 | GRYSKA DAVID WDirector | 4,500 | Direct | Option Exercise at $5 per share. | 22,500 | | Dec 13, 2011 | LIPPMAN MARC EDirector | 6,875 | Direct | Option Exercise at $6.40 per share. | 44,000 | | Dec 8, 2011 | GRYSKA DAVID WDirector | 10,000 | Direct | Sale at $18.09 per share. | 180,900 | | Nov 30, 2011 | SIEGALL CLAY BOfficer | 15,000 | Direct | Option Exercise at $6.34 per share. | 95,100 | | Nov 30, 2011 | SIEGALL CLAY BOfficer | 15,000 | Direct | Automatic Sale at $15.97 per share. | 239,550 | | Nov 8, 2011 | DOBMEIER ERICOfficer | 2,516 | Direct | Option Exercise at $5.25 per share. | 13,209 | | Oct 31, 2011 | SIEGALL CLAY BOfficer | 15,000 | Direct | Option Exercise at $6.34 per share. | 95,100 | | Oct 31, 2011 | SIEGALL CLAY BOfficer | 15,000 | Direct | Automatic Sale at $21.89 per share. | 328,350 | | Oct 26, 2011 | DOBMEIER ERICOfficer | 20,918 | Direct | Automatic Sale at $21.95 per share. | 459,150 | | Oct 26, 2011 | DOBMEIER ERICOfficer | 20,918 | Direct | Option Exercise at $5.81 - $5.92 per share. | 123,0002 | | Oct 19, 2011 | DOBMEIER ERICOfficer | 20,461 | Direct | Option Exercise at $6.74 per share. | 137,907 | | Oct 19, 2011 | DOBMEIER ERICOfficer | 20,461 | Direct | Automatic Sale at $20.58 per share. | 421,087 | | Oct 6, 2011 | SIMPSON TODD EOfficer | 24,350 | Direct | Option Exercise at $5.20 per share. | 126,619 | | Oct 6, 2011 | SIMPSON TODD EOfficer | 24,350 | Direct | Automatic Sale at $21.97 per share. | 534,969 | | Oct 3, 2011 | SIEGALL CLAY BOfficer | 15,000 | Direct | Automatic Sale at $20.15 per share. | 302,250 | | Oct 3, 2011 | SIEGALL CLAY BOfficer | 15,000 | Direct | Option Exercise at $6.34 per share. | 95,100 | | Sep 20, 2011 | SIEGALL CLAY BOfficer | 24,400 | Direct | Option Exercise at $6.34 per share. | 154,696 | | Sep 20, 2011 | SIEGALL CLAY BOfficer | 24,400 | Direct | Sale at $20.15 per share. | 491,660 | | Sep 19, 2011 | SIEGALL CLAY BOfficer | 5,600 | Direct | Sale at $20 per share. | 112,000 | | Sep 19, 2011 | SIEGALL CLAY BOfficer | 5,600 | Direct | Option Exercise at $6.34 per share. | 35,504 | | Sep 8, 2011 | MCLAUGHLIN JOHN PETERDirector | 25,000 | Direct | Option Exercise at $9.82 per share. | 245,500 | | Sep 5, 2011 | BAKER BROTHERS LIFE SCIENCES CAPITAL (GP), LLCDirector | 129,187 | Indirect | Purchase at $17 - $17.27 per share. | 2,214,0002 | | Sep 5, 2011 | 14159 CAPITAL (GP), LLCDirector | 1,773 | Indirect | Purchase at $17 - $17.27 per share. | 30,0002 | | Sep 1, 2011 | SIEGALL CLAY BOfficer | 16,251 | Direct | Option Exercise at $3.30 per share. | 53,628 | | Aug 24, 2011 | BAKER BROTHERS LIFE SCIENCES CAPITAL (GP), LLCDirector | 984,850 | Indirect | Purchase at $15.35 - $15.53 per share. | 15,206,0002 | | Aug 24, 2011 | 14159 CAPITAL (GP), LLCDirector | 15,150 | Indirect | Purchase at $15.35 - $15.53 per share. | 234,0002 | | Aug 23, 2011 | BOERNER CHRISTOPHER S.Officer | 4,500 | Direct | Acquisition (Non Open Market) at $0 per share. | N/A | | Aug 23, 2011 | REYNOLDS THOMAS COfficer | 20,000 | Direct | Acquisition (Non Open Market) at $0 per share. | N/A | | Aug 23, 2011 | BAKER BROTHERS LIFE SCIENCES CAPITAL (GP), LLCDirector | 9,576 | Indirect | Purchase at $14.98 per share. | 143,448 | | Aug 23, 2011 | SIMPSON TODD EOfficer | 13,334 | Direct | Acquisition (Non Open Market) at $0 per share. | N/A | | Aug 23, 2011 | SIEGALL CLAY BOfficer | 60,000 | Direct | Acquisition (Non Open Market) at $0 per share. | N/A | | Aug 23, 2011 | HIMES VAUGHN BOfficer | 11,334 | Direct | Acquisition (Non Open Market) at $0 per share. | N/A | | Aug 23, 2011 | ROSENBERG MORRISOfficer | 11,334 | Direct | Acquisition (Non Open Market) at $0 per share. | N/A | | Aug 23, 2011 | 14159 CAPITAL (GP), LLCDirector | 147 | Indirect | Purchase at $14.98 per share. | 2,202 | | Aug 23, 2011 | SEELEY BRUCE J.Officer | 10,000 | Direct | Acquisition (Non Open Market) at $0 per share. | N/A | | Aug 23, 2011 | DOBMEIER ERICOfficer | 17,334 | Direct | Acquisition (Non Open Market) at $0 per share. | N/A | | Aug 22, 2011 | BAKER BROTHERS LIFE SCIENCES CAPITAL (GP), LLCDirector | 171,009 | Indirect | Purchase at $14.60 - $14.79 per share. | 2,513,0002 | | Aug 22, 2011 | 14159 CAPITAL (GP), LLCDirector | 2,629 | Indirect | Purchase at $14.60 - $14.79 per share. | 39,0002 | | Aug 18, 2011 | REYNOLDS THOMAS COfficer | 7,886 | Direct | Acquisition (Non Open Market) at $0 per share. | N/A | | Aug 18, 2011 | SIEGALL CLAY BOfficer | 18,137 | Direct | Acquisition (Non Open Market) at $0 per share. | N/A | | Aug 18, 2011 | BOERNER CHRISTOPHER S.Officer | 819 | Direct | Acquisition (Non Open Market) at $0 per share. | N/A | | Aug 18, 2011 | HIMES VAUGHN BOfficer | 6,309 | Direct | Acquisition (Non Open Market) at $0 per share. | N/A | | Aug 18, 2011 | SIMPSON TODD EOfficer | 7,886 | Direct | Acquisition (Non Open Market) at $0 per share. | N/A | | Aug 18, 2011 | SEELEY BRUCE J.Officer | 6,309 | Direct | Acquisition (Non Open Market) at $0 per share. | N/A | | Aug 18, 2011 | DOBMEIER ERICOfficer | 7,886 | Direct | Acquisition (Non Open Market) at $0 per share. | N/A | | Aug 18, 2011 | ROSENBERG MORRISOfficer | 6,309 | Direct | Acquisition (Non Open Market) at $0 per share. | N/A | | Jul 31, 2011 | DOBMEIER ERICOfficer | 25,000 | Direct | Option Exercise at $5.25 per share. | 131,250 | | Jul 31, 2011 | REYNOLDS THOMAS COfficer | 1,539 | Direct | Automatic Sale at $17.37 per share. | 26,732 | | Jul 17, 2011 | SIMPSON TODD EOfficer | 18,663 | Direct | Option Exercise at $4.45 - $5.2 per share. | 90,0002 | | Jun 30, 2011 | SIEGALL CLAY BOfficer | 15,000 | Direct | Option Exercise at $6.34 per share. | 95,100 | | Jun 30, 2011 | SIEGALL CLAY BOfficer | 15,000 | Direct | Automatic Sale at $20.66 per share. | 309,900 | | Jun 29, 2011 | BAKER BROS. CAPITAL (GP), LLCDirector | 10,766 | Indirect | Disposition (Non Open Market) at $0 per share. | N/A | | Jun 29, 2011 | BAKER BROTHERS LIFE SCIENCES CAPITAL (GP), LLCDirector | 10,766 | Indirect | Acquisition (Non Open Market) at $0 per share. | N/A | | Jun 21, 2011 | BERGER FRANKLIN MDirector | 7,000 | Direct | Purchase at $20.04 per share. | 140,280 | | Jun 19, 2011 | DOBMEIER ERICOfficer | 13,385 | Direct | Automatic Sale at $20 per share. | 267,700 | | Jun 19, 2011 | SIEGALL CLAY BOfficer | 9,000 | Direct | Option Exercise at $6.34 per share. | 57,060 | | Jun 19, 2011 | SIEGALL CLAY BOfficer | 9,000 | Direct | Automatic Sale at $20.01 per share. | 180,090 |
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| Data provided by EDGAR Online |
* = Where indicated, some values are estimates.
1= Potential proceeds estimated by the filer.
2= Estimated based on the average of multiple prices reported.
3= Multiple dates reported. Most recent date shown.
Currency in USD.
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0.71(2.20%) 4:00PM EDT