| INSIDER TRANSACTIONS REPORTED - LAST TWO YEARS |
| Date | Insider | Shares | Type | Transaction | Value* | | 29-Oct-09 | DOBMEIER ERIC Officer | 6,985 | Direct | Option Exercise at $4.45 - $5.25 per share. | $34,0002 | | 7-Oct-09 | BERGER FRANKLIN M Director | 5,000 | Direct | Option Exercise at $4.18 per share. | $20,900 | | 8-Sep-09 | SIEGALL CLAY B Officer | 10,000 | Direct | Option Exercise at $3 per share. | $30,000 | | 18-Aug-09 | AKKARAJU SRINIVAS Director | 4,905 | Direct | Purchase at $11.47 per share. | $56,260 | | 30-Jul-09 | REYNOLDS THOMAS C Officer | 25,000 | Direct | Option Exercise at $8.24 per share. | $206,000 | | 30-Jul-09 | REYNOLDS THOMAS C Officer | 25,000 | Direct | Sale at $12.47 per share. | $311,750 | | 30-Jul-09 | DOBMEIER ERIC Officer | 33,734 | Direct | Option Exercise at $4.45 - $5.63 per share. | N/A | | 30-Jul-09 | DOBMEIER ERIC Officer | 33,734 | Direct | Sale at $12.36 per share. | $416,952 | | 29-Jul-09 | BERGER FRANKLIN M Director | 5,000 | Direct | Option Exercise at $4.18 per share. | $20,900 | | 29-Jul-09 | DOBMEIER ERIC Officer | 19,266 | Direct | Option Exercise at $4.45 - $5.07 per share. | $92,0002 | | 29-Jul-09 | DOBMEIER ERIC Officer | 26,266 | Direct | Sale at $12.36 per share. | $324,647 | | 28-Jul-09 | ROSENBERG MORRIS Officer | 25,000 | Direct | Option Exercise at $6.72 per share. | $168,000 | | 28-Jul-09 | ROSENBERG MORRIS Officer | 25,000 | Direct | Sale at $11.81 per share. | $295,250 | | 20-Jul-09 | GRYSKA DAVID W Director | 4,000 | Direct | Option Exercise at $5 per share. | $20,000 | | 25-Jun-09 | AKKARAJU SRINIVAS Director | 5,500 | Direct | Purchase at $9.20 - $9.21 per share. | $51,0002 | | 20-May-09 | 14159 CAPITAL (GP), LLC Director | 14,576 | Indirect | Purchase at $9.72 per share. | $141,678 | | 20-May-09 | BAKER BROTHERS LIFE SCIENCES CAPITAL (GP), LLC Director | 746,571 | Indirect | Purchase at $9.72 per share. | $7,256,670 | | 20-May-09 | BAKER / TISCH CAPITAL (GP), LLC Director | 35,253 | Indirect | Purchase at $9.72 per share. | $342,659 | | 20-May-09 | BAKER BROS. CAPITAL (GP), LLC Director | 3,710 | Indirect | Purchase at $9.72 per share. | $36,061 | | 20-May-09 | BAKER BIOTECH CAPITAL (GP), LLC Director | 378,053 | Indirect | Purchase at $9.72 per share. | $3,674,675 | | 15-Dec-08 | DOBMEIER ERIC Officer | 5,000 | Direct | Option Exercise at $5.25 per share. | $26,250 | | 29-Sep-08 | DOBMEIER ERIC Officer | 5,000 | Direct | Option Exercise at $5.25 per share. | $26,250 | | 26-Sep-08 | DOBMEIER ERIC Officer | 24,427 | Direct | Sale at $11.53 per share. | $281,643 | | 22-Sep-08 | REYNOLDS THOMAS C Officer | 12,309 | Direct | Option Exercise at $8.24 per share. | $101,426 | | 22-Sep-08 | REYNOLDS THOMAS C Officer | 12,309 | Direct | Sale at $12.52 per share. | $154,108 | | 22-Sep-08 | AKKARAJU SRINIVAS Director | 18,601 | Indirect | Sale at $12.79 per share. | $237,906 | | 19-Sep-08 | AKKARAJU SRINIVAS Director | 37,011 | Indirect | Sale at $12.74 per share. | $471,520 | | 18-Sep-08 | AKKARAJU SRINIVAS Director | 20,839 | Indirect | Sale at $12.71 per share. | $264,863 | | 16-Sep-08 | DOBMEIER ERIC Officer | 30,000 | Direct | Option Exercise at $4.45 - $5.07 per share. | $143,0002 | | 16-Sep-08 | DOBMEIER ERIC Officer | 30,000 | Direct | Sale at $12.25 per share. | $367,500 | | 4-Aug-08 | ROSENBERG MORRIS Officer | 50,000 | Direct | Option Exercise at $6.72 per share. | $336,000 | | 4-Aug-08 | ROSENBERG MORRIS Officer | 50,000 | Direct | Sale at $11.30 per share. | $565,000 | | 1-Aug-08 | SIEGALL CLAY B Officer | 15,000 | Direct | Option Exercise at $3 per share. | $45,000 | | 29-Jul-08 | AKKARAJU SRINIVAS Director | 95,688 | Indirect | Sale at $10.85 per share. | $1,038,214 | | 28-Jul-08 | H&Q HOLDINGS, INC. Beneficial Owner (10% or more) | 21,500 | Indirect | Sale at $10.36 per share. | $222,740 | | 28-Jul-08 | AKKARAJU SRINIVAS Director | 21,232 | Indirect | Sale at $10.36 per share. | $219,963 | | 28-Jul-08 | JP MORGAN PARTNERS BHCA LP Beneficial Owner (10% or more) | 21,366 | Indirect | Sale at $10.36 per share. | $221,351 | | 25-Jul-08 | JP MORGAN PARTNERS BHCA LP Beneficial Owner (10% or more) | 134 | Indirect | Sale at $10.36 per share. | $1,388 | | 25-Jul-08 | SIEGALL CLAY B Officer | 100,000 | Direct | Sale at $10.78 per share. | $1,078,000 | | 25-Jul-08 | H&Q HOLDINGS, INC. Beneficial Owner (10% or more) | 150,000 | Indirect | Sale at $10.81 per share. | $1,621,500 | | 25-Jul-08 | AKKARAJU SRINIVAS Director | 148,136 | Indirect | Sale at $10.81 per share. | $1,601,350 | | 25-Jul-08 | JP MORGAN PARTNERS BHCA LP Beneficial Owner (10% or more) | 150,000 | Indirect | Sale at $10.81 per share. | $1,621,500 | | 16-May-08 | AKKARAJU SRINIVAS Director | 42,059 | Indirect | Sale at $10.39 per share. | $436,993 | | 15-May-08 | AKKARAJU SRINIVAS Director | 98,758 | Indirect | Sale at $10.14 per share. | $1,001,406 | | 15-May-08 | JP MORGAN PARTNERS BHCA LP Beneficial Owner (10% or more) | 100,000 | Indirect | Sale at $10.14 per share. | $1,014,000 | | 14-May-08 | AKKARAJU SRINIVAS Director | 121,365 | Indirect | Sale at $10.10 per share. | $1,225,786 | | 14-May-08 | H&Q HOLDINGS, INC. Beneficial Owner (10% or more) | 122,893 | Indirect | Sale at $10.10 per share. | $1,241,219 | | 14-May-08 | JP MORGAN PARTNERS BHCA LP Beneficial Owner (10% or more) | 122,893 | Indirect | Sale at $10.10 per share. | $1,241,219 | | 13-May-08 | AKKARAJU SRINIVAS Director | 50,896 | Indirect | Sale at $10.06 per share. | $512,013 | | 13-May-08 | H&Q HOLDINGS, INC. Beneficial Owner (10% or more) | 51,536 | Indirect | Sale at $10.06 per share. | $518,452 | | 13-May-08 | JP MORGAN PARTNERS BHCA LP Beneficial Owner (10% or more) | 51,536 | Indirect | Sale at $10.06 per share. | $518,452 | | 18-Mar-08 | 14159 CAPITAL (GP), LLC Director | 1,673 | Indirect | Purchase at $8.02 per share. | $13,417 | | 18-Mar-08 | BAKER BROTHERS LIFE SCIENCES CAPITAL (GP), LLC Director | 52,736 | Indirect | Purchase at $8.02 per share. | $422,942 | | 18-Mar-08 | BAKER BROS. CAPITAL (GP), LLC Director | 141 | Indirect | Purchase at $8.02 per share. | $1,130 | | 18-Mar-08 | BAKER BIOTECH CAPITAL (GP), LLC Director | 17,793 | Indirect | Purchase at $8.02 per share. | $142,699 | | 17-Mar-08 | 14159 CAPITAL (GP), LLC Director | 2,245 | Indirect | Purchase at $7.80 per share. | $17,511 | | 17-Mar-08 | BAKER BROTHERS LIFE SCIENCES CAPITAL (GP), LLC Director | 70,757 | Indirect | Purchase at $7.80 per share. | $551,904 | | 17-Mar-08 | BAKER BROS. CAPITAL (GP), LLC Director | 189 | Indirect | Purchase at $7.80 per share. | $1,474 | | 17-Mar-08 | BAKER BIOTECH CAPITAL (GP), LLC Director | 23,873 | Indirect | Purchase at $7.80 per share. | $186,209 | | 14-Mar-08 | 14159 CAPITAL (GP), LLC Director | 3,922 | Indirect | Purchase at $8.06 - $8.08 per share. | $32,0002 | | 14-Mar-08 | BAKER BROTHERS LIFE SCIENCES CAPITAL (GP), LLC Director | 123,528 | Indirect | Purchase at $8.06 - $8.08 per share. | $997,0002 | | 14-Mar-08 | BAKER / TISCH CAPITAL (GP), LLC Director | 583 | Indirect | Purchase at $8.06 - $8.08 per share. | $4,7042 | | 14-Mar-08 | BAKER BROS. CAPITAL (GP), LLC Director | 330 | Indirect | Purchase at $8.06 - $8.08 per share. | $2,6632 | | 14-Mar-08 | BAKER BROS. CAPITAL (GP), LLC Director | 330 | Indirect | Purchase at $8.06 - $8.08 per share. | $2,6632 | | 14-Mar-08 | BAKER BIOTECH CAPITAL (GP), LLC Director | 46,306 | Indirect | Purchase at $8.06 - $8.08 per share. | $374,0002 | | 13-Mar-08 | 14159 CAPITAL (GP), LLC Director | 1,219 | Indirect | Purchase at $7.93 per share. | $9,666 | | 13-Mar-08 | BAKER BROTHERS LIFE SCIENCES CAPITAL (GP), LLC Director | 38,404 | Indirect | Purchase at $7.93 per share. | $304,543 | | 13-Mar-08 | BAKER / TISCH CAPITAL (GP), LLC Director | 181 | Indirect | Purchase at $7.93 per share. | $1,435 | | 13-Mar-08 | BAKER BROS. CAPITAL (GP), LLC Director | 103 | Indirect | Purchase at $7.93 per share. | $816 | | 13-Mar-08 | BAKER BROS. CAPITAL (GP), LLC Director | 103 | Indirect | Purchase at $7.93 per share. | $816 | | 13-Mar-08 | BAKER BIOTECH CAPITAL (GP), LLC Director | 14,396 | Indirect | Purchase at $7.93 per share. | $114,160 | | 12-Mar-08 | 14159 CAPITAL (GP), LLC Director | 362 | Indirect | Purchase at $7.98 per share. | $2,888 | | 12-Mar-08 | BAKER BROTHERS LIFE SCIENCES CAPITAL (GP), LLC Director | 11,475 | Indirect | Purchase at $7.98 per share. | $91,570 | | 12-Mar-08 | BAKER / TISCH CAPITAL (GP), LLC Director | 55 | Indirect | Purchase at $7.98 per share. | $438 | | 12-Mar-08 | BAKER BROS. CAPITAL (GP), LLC Director | 31 | Indirect | Purchase at $7.98 per share. | $247 | | 12-Mar-08 | BAKER BROS. CAPITAL (GP), LLC Director | 31 | Indirect | Purchase at $7.98 per share. | $247 | | 12-Mar-08 | BAKER BIOTECH CAPITAL (GP), LLC Director | 4,302 | Indirect | Purchase at $7.98 per share. | $34,329 | | 11-Feb-08 | 14159 CAPITAL (GP), LLC Director | 1,212 | Indirect | Purchase at $9.06 per share. | $10,980 | | 11-Feb-08 | BAKER BROTHERS LIFE SCIENCES CAPITAL (GP), LLC Director | 38,112 | Indirect | Purchase at $9.06 per share. | $345,294 | | 11-Feb-08 | BAKER / TISCH CAPITAL (GP), LLC Director | 723 | Indirect | Purchase at $9.06 per share. | $6,550 | | 11-Feb-08 | BAKER BROS. CAPITAL (GP), LLC Director | 103 | Indirect | Purchase at $9.06 per share. | $933 | | 11-Feb-08 | BAKER BIOTECH CAPITAL (GP), LLC Director | 8,601 | Indirect | Purchase at $9.06 per share. | $77,925 | | 8-Feb-08 | 14159 CAPITAL (GP), LLC Director | 2,852 | Indirect | Purchase at $8.94 - $9 per share. | $26,0002 | | 8-Feb-08 | BAKER BROTHERS LIFE SCIENCES CAPITAL (GP), LLC Director | 89,682 | Indirect | Purchase at $8.94 - $9 per share. | $804,0002 | | 8-Feb-08 | BAKER / TISCH CAPITAL (GP), LLC Director | 338 | Indirect | Purchase at $8.94 - $9 per share. | $3,0312 | | 8-Feb-08 | BAKER BROS. CAPITAL (GP), LLC Director | 242 | Indirect | Purchase at $8.94 - $9 per share. | $2,1702 | | 8-Feb-08 | BAKER BIOTECH CAPITAL (GP), LLC Director | 20,242 | Indirect | Purchase at $8.94 - $9 per share. | $182,0002 | | 7-Feb-08 | 14159 CAPITAL (GP), LLC Director | 819 | Indirect | Purchase at $9 per share. | $7,371 | | 7-Feb-08 | BAKER BROTHERS LIFE SCIENCES CAPITAL (GP), LLC Director | 25,744 | Indirect | Purchase at $9 per share. | $231,696 | | 7-Feb-08 | BAKER / TISCH CAPITAL (GP), LLC Director | 97 | Indirect | Purchase at $9 per share. | $873 | | 7-Feb-08 | BAKER BROS. CAPITAL (GP), LLC Director | 70 | Indirect | Purchase at $9 per share. | $630 | | 7-Feb-08 | BAKER BIOTECH CAPITAL (GP), LLC Director | 5,810 | Indirect | Purchase at $9 per share. | $52,290 | | 23-Jan-08 | 14159 CAPITAL (GP), LLC Director | 3,045 | Indirect | Purchase at $9.03 per share. | $27,496 | | 23-Jan-08 | BAKER BROTHERS LIFE SCIENCES CAPITAL (GP), LLC Director | 95,716 | Indirect | Purchase at $9.03 per share. | $864,315 | | 23-Jan-08 | BAKER / TISCH CAPITAL (GP), LLC Director | 1,915 | Indirect | Purchase at $9.03 per share. | $17,292 | | 23-Jan-08 | BAKER BROS. CAPITAL (GP), LLC Director | 259 | Indirect | Purchase at $9.03 per share. | $2,338 | | 22-Jan-08 | 14159 CAPITAL (GP), LLC Director | 2,084 | Indirect | Purchase at $8.78 per share. | $18,297 | | 22-Jan-08 | BAKER BROTHERS LIFE SCIENCES CAPITAL (GP), LLC Director | 65,139 | Indirect | Purchase at $8.78 per share. | $571,920 | | 22-Jan-08 | BAKER / TISCH CAPITAL (GP), LLC Director | 1,344 | Indirect | Purchase at $8.78 per share. | $11,800 | | 22-Jan-08 | BAKER BROS. CAPITAL (GP), LLC Director | 160 | Indirect | Purchase at $8.78 per share. | $1,404 | | 22-Jan-08 | BAKER BIOTECH CAPITAL (GP), LLC Director | 18,869 | Indirect | Purchase at $8.78 per share. | $165,669 | | 22-Jan-08 | BERGER FRANKLIN M Director | 528 | Direct | Purchase at $9.12 per share. | $4,815 | | 18-Jan-08 | 14159 CAPITAL (GP), LLC Director | 61,872 | Indirect | Purchase at $9 per share. | $556,848 | | 18-Jan-08 | BAKER BROTHERS LIFE SCIENCES CAPITAL (GP), LLC Director | 1,933,423 | Indirect | Purchase at $9 per share. | $17,400,807 | | 18-Jan-08 | BAKER / TISCH CAPITAL (GP), LLC Director | 39,911 | Indirect | Purchase at $9 per share. | $359,199 | | 18-Jan-08 | BAKER BROS. CAPITAL (GP), LLC Director | 4,747 | Indirect | Purchase at $9 per share. | $42,723 | | 18-Jan-08 | BAKER BIOTECH CAPITAL (GP), LLC Director | 560,047 | Indirect | Purchase at $9 per share. | $5,040,423 | | 17-Jan-08 | GRYSKA DAVID W Director | 6,000 | Direct | Option Exercise at $4.18 per share. | $25,080 | | 20-Dec-07 | DOBMEIER ERIC Officer | 5,000 | Direct | Option Exercise at $5.25 per share. | $26,250 | | 14-Dec-07 | LIPPMAN MARC E Director | 20,000 | Direct | Option Exercise at $0.10 per share. | $2,000 | | 10-Dec-07 | AKKARAJU SRINIVAS Director | 20,960 | Indirect | Sale at $12.63 per share. | $264,724 | | 10-Dec-07 | JP MORGAN PARTNERS BHCA LP Beneficial Owner (10% or more) | 21,224 | Indirect | Sale at $12.63 per share. | $268,059 |
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* = Where indicated, some values are estimates. 1 = Potential proceeds estimated by the filer. 2 = Estimated based on the average of multiple prices reported. 3 = Multiple dates reported. Most recent date shown. |
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