| INSIDER TRANSACTIONS REPORTED - LAST TWO YEARS |
| Date | Insider | Shares | Type | Transaction | Value* | | 25-Feb-09 | COURTNEY JEFFREY Director | 1,629,359 | Indirect | Disposition (Non Open Market) | N/A | | 25-Feb-09 | GORDON ERIC M Director | 2,217,908 | Indirect | Disposition (Non Open Market) | N/A | | 25-Feb-09 | SKYLINE VENTURE PARTNERS QUALIFIED PURCHASER FUND Beneficial Owner (10% or more) | 2,217,908 | Indirect | Disposition (Non Open Market) | N/A | | 25-Feb-09 | CROUSE WILLIAM W Director | 58,539 | Direct | Disposition (Non Open Market) | N/A | | 25-Feb-09 | MEHTA DILIP J MD PHD Director | 118,759 | Direct | Disposition (Non Open Market) | N/A | | 25-Feb-09 | MEHTA DILIP J MD PHD Director | 837,194 | Indirect | Disposition (Non Open Market) | N/A | | 20-Nov-08 | ADAGE CAPITAL PARTNERS GP LLC Beneficial Owner (10% or more) | 2,750,971 | Indirect | Statement of Ownership | N/A |
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* = Where indicated, some values are estimates. 1 = Potential proceeds estimated by the filer. 2 = Estimated based on the average of multiple prices reported. 3 = Multiple dates reported. Most recent date shown. |
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